Reactome | MTOR [cytosol]

MTOR [cytosol]

Stable Identifier

R-HSA-165662

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

mTOR

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Locations in the PathwayBrowser

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Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - Active MTORC1 binds the ULK1 complex (Homo sapiens)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
  - Active MTORC1 phosphorylates ULK1 (Homo sapiens)
    - MTOR [cytosol] (Homo sapiens)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
  - MTORC1 dissociates from ULK complex (Homo sapiens)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane] (Homo sapiens)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
  - Rheb in the MTORC1 complex hydrolyses GTP (Homo sapiens)
    - MTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - mTORC2 phosphorylates AKT1 on serine-473 (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
        
        TORC2 complex [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Amino acids regulate mTORC1 (Homo sapiens)
      - RRAGA,B hydrolyzes GTP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
      - mTORC1 binds RHEB:GTP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        TORC2 complex phosphorylates SGK1 (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
        
        TORC2 complex [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN gene transcription (Homo sapiens)
        
        MAF1 translocates to the nucleus (Homo sapiens)
        
        MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
        
        mTORC1 phosphorylates MAF1 (Homo sapiens)
        
        MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
      - MTOR [cytosol] (Homo sapiens)
      - TORC2 complex [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - TORC2 complex phosphorylates SGK1 (Homo sapiens)
      - MTOR [cytosol] (Homo sapiens)
      - TORC2 complex [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
- MTOR signalling (Homo sapiens)
  - AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)
    - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
  - Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
  - Formation of active mTORC1 complex (Homo sapiens)
    - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
      - mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Homo sapiens)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Homo sapiens)
    - mTORC1 [cytosol] (Homo sapiens)
      - MTOR [cytosol] (Homo sapiens)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
      - mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
  - mTORC1 phosphorylates AKT1S1 (Homo sapiens)
    - MTOR [cytosol] (Homo sapiens)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
  - mTORC1-mediated signalling (Homo sapiens)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
      - MTOR [cytosol] (Homo sapiens)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
      - MTOR [cytosol] (Homo sapiens)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - VEGFR2 mediated vascular permeability (Homo sapiens)
        
        TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)
        
        TORC2 complex [cytosol] (Homo sapiens)
        
        MTOR [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P42345 MTOR

Gene Names

MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1

Chain

chain:1-2549

Reference Genes

BioGPS Gene:2475 MTOR

COSMIC (genes):MTOR MTOR

CTD Gene:2475 MTOR

dbSNP Gene:2475 MTOR

ENSEMBL:ENSG00000198793 MTOR

ENSEMBL_homo_sapiens_GENE:ENSG00000198793.14 MTOR

HGNC:3942 MTOR

KEGG Gene (Homo sapiens):2475 MTOR

Monarch:2475 MTOR

NCBI Gene:2475 MTOR

OMIM:601231 MTOR

UCSC:P42345 MTOR

Reference Transcript

Other Identifiers

11716133_a_at

11716134_a_at

11750567_a_at

16681661

202288_PM_at

202288_at

2396538

2396539

2396540

2396541

2396542

2396543

2396544

2396545

2396547

2396548

2396550

2396552

2396555

2396556

2396557

2396560

2396561

2396562

2396563

2396565

2396567

2396569

2396570

2396571

2396572

2396576

2396577

2396580

2396581

2396582

2396584

2396586

2396587

2396588

2396589

2396598

2396599

2396600

2396603

2396604

2396605

2396606

2396607

2396609

2396610

2396611

2396612

2396613

2396614

2396615

2396616

2396617

2396618

2396619

2396620

2396622

2396623

2396625

2396628

2396629

2396633

2396635

2396637

2475

267_at

40139_at

7912412

A_23_P34606

GE81461

GO:0000139

GO:0000166

GO:0001002

GO:0001003

GO:0001006

GO:0001156

GO:0001558

GO:0001932

GO:0001934

GO:0002181

GO:0002296

GO:0002376

GO:0003007

GO:0003012

GO:0003013

GO:0003179

GO:0003677

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005764

GO:0005765

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0005975

GO:0006091

GO:0006112

GO:0006207

GO:0006351

GO:0006355

GO:0006468

GO:0006629

GO:0006914

GO:0006954

GO:0006974

GO:0007010

GO:0007040

GO:0007155

GO:0007281

GO:0007584

GO:0008361

GO:0009267

GO:0009408

GO:0009791

GO:0010506

GO:0010507

GO:0010592

GO:0010628

GO:0010718

GO:0010831

GO:0012501

GO:0012505

GO:0016020

GO:0016236

GO:0016241

GO:0016242

GO:0016301

GO:0016310

GO:0016605

GO:0016740

GO:0018105

GO:0019228

GO:0022414

GO:0023052

GO:0030030

GO:0030154

GO:0030163

GO:0030307

GO:0030425

GO:0030838

GO:0031295

GO:0031410

GO:0031529

GO:0031641

GO:0031648

GO:0031667

GO:0031669

GO:0031670

GO:0031929

GO:0031931

GO:0031932

GO:0032516

GO:0032868

GO:0032869

GO:0032956

GO:0033173

GO:0034198

GO:0035264

GO:0036211

GO:0038202

GO:0042060

GO:0042221

GO:0042752

GO:0042802

GO:0043022

GO:0043066

GO:0043200

GO:0043226

GO:0043231

GO:0043276

GO:0044877

GO:0045335

GO:0045670

GO:0045727

GO:0045792

GO:0045821

GO:0045945

GO:0045948

GO:0046777

GO:0046889

GO:0048266

GO:0048511

GO:0048584

GO:0048709

GO:0048714

GO:0048738

GO:0048856

GO:0048870

GO:0050731

GO:0050877

GO:0050882

GO:0051128

GO:0051219

GO:0051247

GO:0051496

GO:0051549

GO:0051647

GO:0051896

GO:0051897

GO:0055006

GO:0055013

GO:0055086

GO:0060048

GO:0065003

GO:0070885

GO:0071230

GO:0071233

GO:0071456

GO:0071470

GO:0080135

GO:0090559

GO:0106310

GO:0140096

GO:1900034

GO:1900181

GO:1901135

GO:1901796

GO:1901838

GO:1903691

GO:1904059

GO:1904690

GO:1905672

GO:1905857

GO:1990253

GO:2000785

HMNXSV003015930

ILMN_1769031

L34075_at

PH_hs_0016579

TC01002197.hg

g3282238_3p_at

Participates

as a component of

Other forms of this molecule

MTOR [nucleoplasm]

Inferred To

MTOR [cytosol] (Bos taurus)

MTOR [cytosol] (Canis familiaris)

MTOR [cytosol] (Gallus gallus)

MTOR [cytosol] (Mus musculus)

MTOR [cytosol] (Rattus norvegicus)

MTOR [cytosol] (Sus scrofa)

mTor [cytosol] (Drosophila melanogaster)

tor2 [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of MTOR [cytosol] (Xenopus tropicalis)

TOR2 [cytosol] (Saccharomyces cerevisiae)

tor [cytosol] (Dictyostelium discoideum)

let-363 [cytosol] (Caenorhabditis elegans)

mtor [cytosol] (Danio rerio)

Cross References

RefSeq

XP_005263495.1, NP_004949.1

ZINC - World Drugs

MTOR_HUMAN

Guide to Pharmacology - Targets

2109

OpenTargets

ENSG00000198793

ZINC - FDA approved

MTOR_HUMAN

ZINC - Substances

MTOR_HUMAN

ZINC target

P42345

PRO

P42345

PDB

4JT6, 7UXC, 6M4W, 6M4U, 7PE9, 6ZWM, 7UXH, 4DRH, 7TZO, 8PPZ, 2NPU, 7PEB, 4DRI, 1AUE, 4DRJ, 4FAP, 6BCU, 3FAP, 7PEC, 5FLC, 2RSE, 2FAP, 5WBU, 5GPG, 2GAQ, 5WBY, 1NSG, 7PE7, 6BCX, 1FAP, 5H64, 7EPD, 7PE8, 4JSP, 3JBZ, 6SB2, 4JSN, 8ER7, 8ER6, 5ZCS, 6SB0, 5WBH, 7PEA, 6ZWO, 4JSV, 8ERA, 7OWG, 4JT5, 4JSX

ZINC - Investigational

MTOR_HUMAN

GeneCards

P42345

HPA

ENSG00000198793-MTOR

Ensembl

ENSG00000198793, ENST00000361445, ENSP00000354558

Pharos - Targets

P42345

Orphanet

23236

ZINC - Predictions - Purchasable

MTOR_HUMAN

HMDB Protein

HMDBP02611

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62942 FKBP1A	1	FKBP1A [cytosol] (R-HSA-2026007)	0.786	5
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.731	4
UniProt:O75385 ULK1	7	ULK1 [recycling endosome] (R-HSA-8854761) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145)	0.702	7
UniProt:Q96B36 AKT1S1	4	AKT1S1 [nucleoplasm] (R-HSA-5083637) p-T246-AKT1S1 [cytosol] (R-HSA-377124) p-S183,T246-AKT1S1 [cytosol] (R-HSA-200163) AKT1S1 [cytosol] (R-HSA-200155)	0.669	3
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.65	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.536	2
UniProt:Q9NZQ7 CD274	1	CD274 [plasma membrane] (R-HSA-3211776)	0.527	2
UniProt:O75695 RP2	1	RP2 [cilium] (R-HSA-5624052)	0.527	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.525	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.483	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.483	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	4

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