Reactome | p-T412-RPS6KB1 [cytosol]

p-T412-RPS6KB1 [cytosol]

Stable Identifier

R-HSA-165714

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

S6K1-P

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P23443 RPS6KB1

Gene Names

RPS6KB1, STK14A

Chain

chain:1-525

Reference Genes

BioGPS Gene:6198 RPS6KB1

COSMIC (genes):RPS6KB1 RPS6KB1

CTD Gene:6198 RPS6KB1

dbSNP Gene:6198 RPS6KB1

ENSEMBL:ENSG00000108443 RPS6KB1

HGNC:10436 RPS6KB1

KEGG:hsa:6198 RPS6KB1

Monarch:6198 RPS6KB1

NCBI Gene:6198 RPS6KB1

OMIM:608938 RPS6KB1

UCSC:P23443 RPS6KB1

Reference Transcript

Participates

as an output of

mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)

Other forms of this molecule

RPS6KB1 [cytosol]

Inferred To

phospho-p-T412-RPS6KB1 [cytosol] (Canis familiaris)

phospho-p-T412-RPS6KB1 [cytosol] (Dictyostelium discoideum)

phospho-p-T412-RPS6KB1 [cytosol] (Gallus gallus)

phospho-Rps6kb1 [cytosol] (Mus musculus)

phospho-Rps6kb1 [cytosol] (Rattus norvegicus)

phospho-S6k [cytosol] (Drosophila melanogaster)

phospho-rsks-1 [cytosol] (Caenorhabditis elegans)

phospho-psk1 [cytosol] (Schizosaccharomyces pombe)

phospho-RPS6KB1 [cytosol] (Bos taurus)

phospho-RPS6KB1 [cytosol] (Sus scrofa)

phospho-rps6kb1b [cytosol] (Danio rerio)

phospho-YPK3 [cytosol] (Saccharomyces cerevisiae)

Modified Residues

Name

O-phospho-L-threonine at 412

Coordinate

412

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_003152.1, NP_001258972.1, NP_001258973.1, NP_001258971.1, NP_001258989.1

ZINC - World Drugs

KS6B1_HUMAN

Guide to Pharmacology - Targets

1525

OpenTargets

ENSG00000108443

ENSEMBL

ENSG00000108443, ENSP00000376744, ENSP00000441993, ENSP00000225577, ENST00000393021, ENST00000443572, ENSP00000384335, ENST00000225577, ENST00000406116

ZINC - FDA approved

KS6B1_HUMAN

ZINC - Substances

KS6B1_HUMAN

ZINC - Biogenic

KS6B1_HUMAN

ZINC target

P23443

PRO

P23443

GlyGen

P23443

PDB

3WF8, 4L42, 7N91, 3WF9, 4L3J, 4L43, 3WE4, 3A61, 7N93, 4RLP, 5WBH, 3WF5, 4L44, 5WBK, 3WF6, 3A62, 4L45, 3WF7, 4L46, 4L3L, 4RLO, 3A60

ZINC - Investigational

KS6B1_HUMAN

HPA

ENSG00000108443-RPS6KB1

GeneCards

RPS6KB1

Pharos - Targets

P23443

ZINC - Predictions - Purchasable

KS6B1_HUMAN

HMDB Protein

HMDBP01426

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.64	3
UniProt:P55884 EIF3B	1	EIF3B [cytosol] (R-HSA-72542)	0.564	3
UniProt:Q06481-5 APLP2			0.556	3
UniProt:P13051-2 UNG			0.556	3
UniProt:Q13057 COASY	1	COASY [mitochondrial outer membrane] (R-HSA-196735)	0.544	4
UniProt:Q00005 2ABB			0.499	2

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