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p-T412-RPS6KB1 [cytosol]
Stable Identifier
R-HSA-165714
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
S6K1-P
Locations in the PathwayBrowser for interactor UniProt:Q00005 2ABB
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
Phosphorylation and activation of eIF4B by activated S6K1 (Homo sapiens)
p-T412-RPS6KB1 [cytosol] (Homo sapiens)
Phosphorylation and activation of eIF4G by activated S6K1 (Homo sapiens)
p-T412-RPS6KB1 [cytosol] (Homo sapiens)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Homo sapiens)
p-T412-RPS6KB1 [cytosol] (Homo sapiens)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Homo sapiens)
p-T412-RPS6KB1 [cytosol] (Homo sapiens)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
p-T412-RPS6KB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23443 RPS6KB1
Gene Names
RPS6KB1, STK14A
Chain
chain:1-525
Reference Genes
BioGPS Gene:6198 RPS6KB1
COSMIC (genes):RPS6KB1 RPS6KB1
CTD Gene:6198 RPS6KB1
dbSNP Gene:6198 RPS6KB1
ENSEMBL:ENSG00000108443 RPS6KB1
ENSEMBL_homo_sapiens_GENE:ENSG00000108443.14 RPS6KB1
HGNC:10436 RPS6KB1
KEGG Gene (Homo sapiens):6198 RPS6KB1
Monarch:6198 RPS6KB1
NCBI Gene:6198 RPS6KB1
OMIM:608938 RPS6KB1
UCSC:P23443 RPS6KB1
Reference Transcript
RefSeq:NM_001272043.1 RPS6KB1
RefSeq:NM_001272044.1 RPS6KB1
RefSeq:NM_001272042.1 RPS6KB1
RefSeq:NM_001272060.1 RPS6KB1
RefSeq:NM_003161.3 RPS6KB1
Other Identifiers
11723299_a_at
11723300_at
11723301_s_at
11747836_a_at
11750648_x_at
11752465_a_at
11752466_s_at
16836626
17121602
17121812
2037_s_at
204171_PM_at
204171_at
211578_PM_s_at
211578_s_at
226660_PM_at
226660_at
3714522
3714523
3714529
3714531
3714533
3714537
3714539
3714543
3714545
3714549
3714551
3719610
3729295
3729296
3729297
3729298
3729300
3729305
3729306
3729307
3729311
3729312
3729318
3729320
3729321
3729324
3729327
3729329
3729332
3729334
3729335
3729336
3729337
3729338
3729339
3729340
3729341
3729342
3729343
3754090
3754150
3754153
3765831
3765833
3765834
3765836
3765837
3765841
3765842
37946_at
4040904
4040948
6198
8008887
82929_at
90022_at
A_14_P119384
A_21_P0011529
A_21_P0011601
A_23_P141329
A_24_P387179
A_24_P497226
GE58003
GO:0000082
GO:0000166
GO:0000278
GO:0001662
GO:0002376
GO:0003009
GO:0003012
GO:0003824
GO:0004672
GO:0004674
GO:0004711
GO:0004712
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0006417
GO:0006468
GO:0006915
GO:0007049
GO:0007165
GO:0007281
GO:0007584
GO:0007616
GO:0009410
GO:0009612
GO:0009636
GO:0009749
GO:0009986
GO:0010033
GO:0010243
GO:0012501
GO:0014070
GO:0014732
GO:0014878
GO:0014911
GO:0016020
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0018105
GO:0022414
GO:0023052
GO:0030154
GO:0030165
GO:0031667
GO:0031670
GO:0031929
GO:0032496
GO:0032868
GO:0032869
GO:0032870
GO:0033574
GO:0033762
GO:0034612
GO:0036211
GO:0042277
GO:0042802
GO:0043005
GO:0043066
GO:0043200
GO:0043201
GO:0043226
GO:0043434
GO:0043491
GO:0044539
GO:0045202
GO:0045471
GO:0045727
GO:0045931
GO:0045948
GO:0046324
GO:0046627
GO:0048015
GO:0048471
GO:0048633
GO:0048661
GO:0048856
GO:0048870
GO:0050804
GO:0050877
GO:0051384
GO:0051721
GO:0055085
GO:0071346
GO:0071363
GO:0071407
GO:0071549
GO:0098542
GO:0098794
GO:0098978
GO:0106310
GO:0140096
GO:1904263
GO:2001237
HMNXSV003030273
HMNXSV003045873
HMNXSV003049476
Hs.146217.0.S1_3p_at
ILMN_1704557
PH_hs_0036671
TC17000729.hg
TC17002113.hg
TC17002739.hg
g189509_3p_a_at
g4506736_3p_at
Participates
as an output of
mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
Other forms of this molecule
RPS6KB1 [cytosol]
Inferred To
phospho-p-T412-RPS6KB1 [cytosol]
(Bos taurus)
phospho-p-T412-RPS6KB1 [cytosol]
(Caenorhabditis elegans)
phospho-p-T412-RPS6KB1 [cytosol]
(Danio rerio)
phospho-p-T412-RPS6KB1 [cytosol]
(Dictyostelium discoideum)
phospho-p-T412-RPS6KB1 [cytosol]
(Drosophila melanogaster)
phospho-p-T412-RPS6KB1 [cytosol]
(Gallus gallus)
phospho-p-T412-RPS6KB1 [cytosol]
(Mus musculus)
phospho-p-T412-RPS6KB1 [cytosol]
(Rattus norvegicus)
phospho-p-T412-RPS6KB1 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-T412-RPS6KB1 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-T412-RPS6KB1 [cytosol]
(Sus scrofa)
phospho-RPS6KB1 [cytosol]
(Canis familiaris)
Modified Residues
Name
O-phospho-L-threonine at 412
Coordinate
412
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001258971.1
,
NP_001258972.1
,
NP_001258973.1
,
NP_003152.1
,
NP_001258989.1
ZINC - World Drugs
KS6B1_HUMAN
Guide to Pharmacology - Targets
1525
OpenTargets
ENSG00000108443
ZINC - FDA approved
KS6B1_HUMAN
ZINC - Substances
KS6B1_HUMAN
ZINC - Biogenic
KS6B1_HUMAN
ZINC target
P23443
PRO
P23443
PDB
4RLP
,
4RLO
,
4L3L
,
3A62
,
3WE4
,
3WF8
,
7N91
,
4L46
,
4L42
,
3WF7
,
4L45
,
5WBH
,
3A61
,
4L43
,
4L3J
,
5WBK
,
3A60
,
7N93
,
3WF6
,
3WF9
,
4L44
,
3WF5
ZINC - Investigational
KS6B1_HUMAN
HPA
ENSG00000108443-RPS6KB1
GeneCards
P23443
Ensembl
ENSP00000441993
,
ENST00000225577
,
ENSP00000225577
,
ENSP00000384335
,
ENSP00000376744
,
ENST00000406116
,
ENST00000443572
,
ENST00000393021
,
ENSG00000108443
Pharos - Targets
P23443
ZINC - Predictions - Purchasable
KS6B1_HUMAN
HMDB Protein
HMDBP01426
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.64
3
UniProt:P55884 EIF3B
1
EIF3B [cytosol]
(R-HSA-72542)
0.564
3
UniProt:P13051-2 UNG
0.556
3
UniProt:Q06481-5 APLP2
0.556
3
UniProt:Q13057 COASY
1
COASY [mitochondrial outer membrane]
(R-HSA-196735)
0.544
4
UniProt:Q00005 2ABB
0.499
2
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