Reactome | RPS6KB1 [cytosol]

RPS6KB1 [cytosol]

Stable Identifier

R-HSA-165716

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

S6K1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P23443 RPS6KB1

Gene Names

RPS6KB1, STK14A

Chain

chain:1-525

Reference Genes

COSMIC (genes):RPS6KB1 RPS6KB1

dbSNP Gene:6198 RPS6KB1

ENSEMBL:ENSG00000108443 RPS6KB1

Participates

as an input of

mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)

Other forms of this molecule

p-T412-RPS6KB1 [cytosol]

Inferred To

RPS6KB1 [cytosol] (Bos taurus)

RPS6KB1 [cytosol] (Caenorhabditis elegans)

RPS6KB1 [cytosol] (Canis familiaris)

RPS6KB1 [cytosol] (Danio rerio)

RPS6KB1 [cytosol] (Dictyostelium discoideum)

RPS6KB1 [cytosol] (Drosophila melanogaster)

RPS6KB1 [cytosol] (Gallus gallus)

RPS6KB1 [cytosol] (Mus musculus)

RPS6KB1 [cytosol] (Rattus norvegicus)

RPS6KB1 [cytosol] (Saccharomyces cerevisiae)

RPS6KB1 [cytosol] (Schizosaccharomyces pombe)

RPS6KB1 [cytosol] (Sus scrofa)

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.64	3
UniProt:P55884 EIF3B	1	EIF3B [cytosol] (R-HSA-72542)	0.564	3
UniProt:P13051-2 UNG			0.556	3
UniProt:Q06481-5 APLP2			0.556	3
UniProt:Q13057 COASY	1	COASY [mitochondrial outer membrane] (R-HSA-196735)	0.544	4
UniProt:Q00005 2ABB			0.499	2

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