mTORC1 phosphorylation of RPS6KB1 (S6K)

Stable Identifier
R-HSA-165718
Type
Reaction [transition]
Species
Homo sapiens
Compartment
lysosomal membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
mTORC1 phosphorylation of RPS6KB1 (S6K)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RPS6KB1 (S6K1) contains a TOS motif. mTORC1 requires an intact TOS motif to bind and phosphorylate S6K1 (Ali & Sabatini 2005).

Literature References
PubMed ID Title Journal Year
15809305 Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR

Ali, SM, Sabatini, DM

J Biol Chem 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of Active mTORC1 complex [lysosomal membrane]

Physical Entity
Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
This event is regulated
Negatively by
Regulator
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
Regulator
FKBP1A:sirolimus [cytosol] (Homo sapiens)
Positively by
Regulator
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
Orthologous Events
mTORC1 phosphorylation of RPS6KB1 (S6K) (Bos taurus)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Caenorhabditis elegans)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Canis familiaris)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Danio rerio)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Drosophila melanogaster)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Gallus gallus)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Mus musculus)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Rattus norvegicus)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Sus scrofa)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Xenopus tropicalis)
Authored
Jupe, S  (2015-01-23)
Reviewed
Zwartkruis, FJ  (2015-05-14)
Created
de Bono, B  (2005-08-09)
Cite Us!