Phosphorylation of Ribosomal protein S6 by activated S6K1

Stable Identifier
R-HSA-165726
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of Ribosomal protein S6 by activated S6K1
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Once phosphorylated, S6K1-P phosphorylates and activates ribosomal protein S6 (rpS6), which in turn selectively increases the translation of 5'-TOP mRNAs. These mRNAs encode exclusively for components of the translation machinery (PMID 15809305).

Literature References
PubMed ID Title Journal Year
15809305 Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR

Ali, SM, Sabatini, DM

J Biol Chem 2005
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Catalyst Activity

protein serine/threonine kinase activity of p-T412-RPS6KB1 [cytosol]

Physical Entity
p-T412-RPS6KB1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Bos taurus)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Caenorhabditis elegans)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Canis familiaris)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Danio rerio)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Drosophila melanogaster)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Gallus gallus)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Mus musculus)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Rattus norvegicus)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Saccharomyces cerevisiae)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Schizosaccharomyces pombe)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Xenopus tropicalis)
Authored
Jupe, S  (2015-01-23)
Reviewed
Zwartkruis, FJ  (2015-05-14)
Created
de Bono, B  (2005-08-09)
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