Once phosphorylated, S6K1-P phosphorylates and activates ribosomal protein S6 (rpS6), which in turn selectively increases the translation of 5'-TOP mRNAs. These mRNAs encode exclusively for components of the translation machinery (PMID 15809305).
Ali, SM, Sabatini, DM
protein serine/threonine kinase activity of p-T412-RPS6KB1 [cytosol]
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