Reactome | p-S1108,S1148,S1192-EIF4G1 [cytosol]

p-S1108,S1148,S1192-EIF4G1 [cytosol]

Stable Identifier

R-HSA-165762

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF4G-P

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Locations in the PathwayBrowser for interactor UniProt:Q13112 CAF1B

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General

Serine residues 1108, 1148, 1192 of the EIF4G1 isoform in Raught et al. (2000) correspond to serine residues 1147, 1185, and 1231 of the UniProt reference sequence.

Literature References

PubMed ID	Title	Journal	Year
10654941	Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI Sonenberg, N, Aebersold, R, Gradi, A, Raught, B, Gygi, SP, Imataka, H, Gingras, AC, Morino, S	EMBO J	2000

External Reference Information

External Reference

UniProt:Q04637 EIF4G1

Gene Names

EIF4G1, EIF4F, EIF4G, EIF4GI

Chain

initiator methionine:, chain:1-1599

Reference Genes

COSMIC (genes):EIF4G1 EIF4G1

dbSNP Gene:1981 EIF4G1

ENSEMBL:ENSG00000114867 EIF4G1

Participates

as an output of

Phosphorylation and activation of eIF4G by activated S6K1 (Homo sapiens)

Other forms of this molecule

EIF4G1 [cytosol]

Inferred To

phospho-tif471 [cytosol] (Schizosaccharomyces pombe)

phospho-EIF4G1 [cytosol] (Bos taurus)

phospho-EIF4G1 [cytosol] (Canis familiaris)

phospho-EIF4G1 [cytosol] (Sus scrofa)

phospho-ifg-1 [cytosol] (Caenorhabditis elegans)

phospho-eif4g [cytosol] (Dictyostelium discoideum)

phospho-eIF4G1 [cytosol] (Drosophila melanogaster)

phospho-Eif4g1 [cytosol] (Mus musculus)

phospho-Eif4g1 [cytosol] (Rattus norvegicus)

phospho-TIF4631 [cytosol] (Saccharomyces cerevisiae)

phospho-eif4g1 [cytosol] (Xenopus tropicalis)

Homologues of p-S1108,S1148,S1192-EIF4G1 [cytosol] (Drosophila melanogaster)

Homologues of p-S1108,S1148,S1192-EIF4G1 [cytosol] (Plasmodium falciparum)

phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol] (Gallus gallus)

phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol] (Plasmodium falciparum)

phospho-eIF4G2 [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-serine at 1147

Coordinate

1147

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1185

Coordinate

1185

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1231

Coordinate

1231

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60842 EIF4A1	1	EIF4A1 [cytosol] (R-HSA-72573)	0.964	17
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.924	13
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.835	6
UniProt:Q14240 EIF4A2	1	EIF4A2 [cytosol] (R-HSA-72575)	0.656	4
UniProt:Q9BWF3-1 RBM4			0.591	4
UniProt:Q9UGR2 Z3H7B			0.567	3
UniProt:P55884 EIF3B	1	EIF3B [cytosol] (R-HSA-72542)	0.564	2
UniProt:P23116	1	Eif3a [cytosol] (R-MMU-72546)	0.564	2
UniProt:Q9BUB5 MKNK1	1	p-T250,T255,T385,S437-MKNK1 [cytosol] (R-HSA-947860)	0.564	3
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.557	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.528	3
UniProt:Q06787 FMR1			0.527	2
UniProt:Q13112 CAF1B			0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:O75822 EIF3J	1	EIF3J [cytosol] (R-HSA-72534)	0.524	2
UniProt:Q9J0X9 Q9J0X9			0.499	3
UniProt:Q14103-4 HNRNPD	2	HNRNPD-4 [cytosol] (R-HSA-450442) Ub-HNRNPD-4 [cytosol] (R-HSA-451232)	0.499	3
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.491	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:P51116 FXR2			0.483	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.483	2
UniProt:Q00721 NSP3			0.482	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.462	2

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