Phosphorylation and activation of eIF4B by activated S6K1

Stable Identifier
R-HSA-165777
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation and activation of eIF4B by activated S6K1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

eIF4B is a physiologically relevant target of S6K1. Once phosphorylated and activated by S6K1, eIF4B specifically stimulates the ATPase and RNA helicase activities of eIF4A.

Literature References
PubMed ID Title Journal Year
15314020 Upstream and downstream of mTOR

Hay, N, Sonenberg, N

Genes Dev 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T412-RPS6KB1 [cytosol]

Physical Entity
p-T412-RPS6KB1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation and activation of eIF4B by activated S6K1 (Bos taurus)
Phosphorylation and activation of eIF4B by activated S6K1 (Canis familiaris)
Phosphorylation and activation of eIF4B by activated S6K1 (Danio rerio)
Phosphorylation and activation of eIF4B by activated S6K1 (Gallus gallus)
Phosphorylation and activation of eIF4B by activated S6K1 (Mus musculus)
Phosphorylation and activation of eIF4B by activated S6K1 (Rattus norvegicus)
Phosphorylation and activation of eIF4B by activated S6K1 (Sus scrofa)
Phosphorylation and activation of eIF4B by activated S6K1 (Xenopus tropicalis)
Authored
Jupe, S  (2015-01-23)
Reviewed
Zwartkruis, FJ  (2015-05-14)
Created
de Bono, B  (2005-08-09)
Cite Us!