Reactome | PPP2CA [cytosol]

PPP2CA [cytosol]

Stable Identifier

R-HSA-165971

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP2A-catalytic subunit C alpha isoform

Locations in the PathwayBrowser for interactor UniProt:Q14674 ESPL1

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External Reference Information

External Reference

UniProt:P67775 PPP2CA

Gene Names

PPP2CA

Chain

chain:1-309

Reference Genes

COSMIC (genes):PPP2CA PPP2CA

dbSNP Gene:5515 PPP2CA

ENSEMBL:ENSG00000113575 PPP2CA

Participates

as an input of

PPP2CA and PPP2R1A,B bind PPP2R2A in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin (Homo sapiens)

as a component of

as a member of

PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)

as a candidate of

PP2A-catalytic subunit C [cytosol] (Homo sapiens)

Other forms of this molecule

PPP2CA [nucleoplasm]

p-Y307-PPP2CA [cytosol]

MeL-PPP2CA [nucleoplasm]

Inferred To

PPP2CA [cytosol] (Bos taurus)

PPP2CA [cytosol] (Caenorhabditis elegans)

PPP2CA [cytosol] (Canis familiaris)

PPP2CA [cytosol] (Dictyostelium discoideum)

PPP2CA [cytosol] (Drosophila melanogaster)

PPP2CA [cytosol] (Gallus gallus)

PPP2CA [cytosol] (Mus musculus)

PPP2CA [cytosol] (Plasmodium falciparum)

PPP2CA [cytosol] (Rattus norvegicus)

PPP2CA [cytosol] (Saccharomyces cerevisiae)

PPP2CA [cytosol] (Schizosaccharomyces pombe)

PPP2CA [cytosol] (Sus scrofa)

ppp2caa [cytosol] (Danio rerio)

ppp2ca [cytosol] (Xenopus tropicalis)

Interactors (113)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.984	50
UniProt:P78318 IGBP1			0.959	20
UniProt:Q13362 PPP2R5C	3	PPP2R5C [nucleoplasm] (R-HSA-3008946) p-S337-PPP2R5C [cytosol] (R-HSA-6811447) PPP2R5C [cytosol] (R-HSA-3008954)	0.934	11
UniProt:P30154 PPP2R1B	2	PPP2R1B [nucleoplasm] (R-HSA-166000) PPP2R1B [cytosol] (R-HSA-165980)	0.919	9
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.915	12
UniProt:Q15173 PPP2R5B	2	p-S368-PPP2R5B [cytosol] (R-HSA-6811453) PPP2R5B [cytosol] (R-HSA-535469)	0.908	8
UniProt:Q15172 PPP2R5A	2	p-S28-PPP2R5A [cytosol] (R-HSA-9836658) PPP2R5A [cytosol] (R-HSA-196235)	0.903	8
UniProt:Q5VSL9 STRP1			0.899	10
UniProt:Q9Y570 PPME1	1	PPME1 [nucleoplasm] (R-HSA-8857790)	0.877	9
UniProt:Q14738 PPP2R5D	2	PPP2R5D [nucleoplasm] (R-HSA-3008956) PPP2R5D [cytosol] (R-HSA-3008950)	0.864	8
UniProt:Q13136 PPFIA1	1	PPFIA1 [cytosol] (R-HSA-383377)	0.864	8
UniProt:Q16537 PPP2R5E	1	PPP2R5E [cytosol] (R-HSA-1638770)	0.855	7
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.848	10
UniProt:Q5FBB7 SGO1	1	SGOL1 [cytosol] (R-HSA-376227)	0.848	7
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.84	7
UniProt:Q13033 STRN3			0.831	9
UniProt:Q9Y3A3 PHOCN			0.823	9
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.788	5
UniProt:Q15645 PCH2			0.764	6
UniProt:Q9NRL3 STRN4			0.758	5
UniProt:O75145 PPFIA3	1	PPFIA3 [cytosol] (R-HSA-383382)	0.758	5
UniProt:P78371 CCT2	3	CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220) CCT2 [cytosol] (R-HSA-390464)	0.758	5
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.758	5
UniProt:Q9P2B4 CT2NL			0.758	6
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.756	4
UniProt:Q14BN4 SLMAP			0.745	5
UniProt:Q76MZ3 Ppp2r1a	2	Ppp2r1a [nucleoplasm] (R-MMU-165968) PP2A A subunit [cytosol] (R-MMU-206067)	0.743	4
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.725	4
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.725	4
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.725	4
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.725	5
UniProt:Q16204 CCDC6			0.725	4
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.725	4
UniProt:P50990 CCT8	5	CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [cytosol] (R-HSA-390449)	0.725	4
UniProt:Q9Y2T4 2ABG			0.708	6
UniProt:P22830 FECH	1	FECH [mitochondrial inner membrane] (R-HSA-189441)	0.671	4
UniProt:Q96CB8 INTS12	1	INTS12 [nucleoplasm] (R-HSA-6807456)	0.643	3
UniProt:Q9NVR7 TBCC1			0.643	3
UniProt:Q9Y5P8 PPP2R3B	1	PPP2R3B [nucleoplasm] (R-HSA-3008955)	0.643	3
UniProt:Q9UL03 INTS6	1	INTS6 [nucleoplasm] (R-HSA-6807440)	0.643	3
UniProt:Q8TF05 PP4R1			0.643	3
UniProt:Q5THK1 PR14L			0.643	3
UniProt:Q13033-2 STRN3			0.643	4
UniProt:Q9Y6E0 STK24	4	STK24 [cytosol] (R-HSA-351829) STK24(1-313) [cytosol] (R-HSA-351892) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [nucleoplasm] (R-HSA-351944)	0.643	3
UniProt:Q9NVK5 FGFR1OP2	2	FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (R-HSA-1606443) FGFR1OP(1-132)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838998)	0.643	4
UniProt:Q96HW7 INTS4	1	INTS4 [nucleoplasm] (R-HSA-6807462)	0.643	3
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) ub-AXIN1 [cytosol] (R-HSA-4641133) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.643	4
UniProt:Q06190 P2R3A			0.643	4
UniProt:O00506 STK25			0.643	3
UniProt:Q86XL3 ANKLE2	2	Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (R-HSA-9667946) ANKLE2 [endoplasmic reticulum membrane] (R-HSA-2529000)	0.643	3
UniProt:Q9P289 STK26	3	MST4(306-416) [cytosol] (R-HSA-351903) MST4(1-305) [cytosol] (R-HSA-351855) MST4 [cytosol] (R-HSA-351918)	0.643	4
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.641	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.641	4
UniProt:Q61249 IGBP1			0.602	3
UniProt:P03129 VE7			0.602	3
UniProt:Q14674 ESPL1	4	ESPL1(1-1506) [cytosol] (R-HSA-2467768) ESPL1(1507-1535) [cytosol] (R-HSA-2500272) ESPL1(1536-2120) [cytosol] (R-HSA-2467767) ESPL1 [cytosol] (R-HSA-1638167)	0.597	3
UniProt:Q00005 2ABB			0.597	5
UniProt:Q969F8 KISS1R	1	KISS1R [plasma membrane] (R-HSA-388974)	0.593	3
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.591	6
UniProt:O75663 TIPRL			0.589	3
UniProt:Q562F6 SGO2	1	SGOL2 [cytosol] (R-HSA-376242)	0.564	2
UniProt:Q9UPQ4-2 Q9UPQ42			0.556	3
UniProt:Q5T6F2 UBAP2			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q16740 CLPP	1	CLPP [mitochondrial matrix] (R-HSA-9838002)	0.556	3
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:Q3SXR2 CC036			0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.544	2
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.544	2
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.544	2
UniProt:Q9NV88 INTS9	1	INTS9 [nucleoplasm] (R-HSA-6807424)	0.527	2
UniProt:Q9H0H0 INTS2	1	INTS2 [nucleoplasm] (R-HSA-6807448)	0.527	2
UniProt:Q9BWN1 PRR14			0.527	2
UniProt:Q77M19 Q77M19			0.527	2
UniProt:Q5TA45 CPSF3L	1	CPSF3L [nucleoplasm] (R-HSA-6807411)	0.527	2
UniProt:Q9NVR2 INTS10	1	INTS10 [nucleoplasm] (R-HSA-6807420)	0.527	2
UniProt:Q969G9 NKD1			0.527	2
UniProt:Q9NQX6 ZNF331	1	ZNF331 [nucleoplasm] (R-HSA-1247549)	0.527	3
UniProt:O95684 CEP43	3	FGFR1OP(2-163)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604533) FGFR1OP(2-163)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838994) FGFR1OP [cytosol] (R-HSA-380309)	0.527	2
UniProt:Q6ZMY9 ZNF517	1	ZNF517 [nucleoplasm] (R-HSA-1973869)	0.527	2
UniProt:O43638 FOXS1			0.527	2
UniProt:Q8IYG6 LRC56			0.527	2
UniProt:Q96SY0 VWA9	1	VWA9 [nucleoplasm] (R-HSA-6807412)	0.527	2
UniProt:Q9NVH2 INTS7	1	INTS7 [nucleoplasm] (R-HSA-6807401)	0.527	2
UniProt:Q12950 FOXD4			0.527	3
UniProt:Q9NUC0 SRTD4			0.527	3
UniProt:P42695 NCAPD3	3	p-T1415,S1419-NCAPD3 [nucleoplasm] (R-HSA-2294594) p-T1415-NCAPD3 [nucleoplasm] (R-HSA-2294587) NCAPD3 [nucleoplasm] (R-HSA-1629790)	0.527	2
UniProt:Q8NC26 ZNF114	1	ZNF114 [nucleoplasm] (R-HSA-975026)	0.527	2
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.527	2
UniProt:Q9BXL8 CDCA4			0.527	4
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.527	2
UniProt:Q7Z398 ZNF550	1	ZNF550 [nucleoplasm] (R-HSA-1973896)	0.527	2
UniProt:Q6P9B9 INTS5	1	INTS5 [nucleoplasm] (R-HSA-6807418)	0.527	2
UniProt:O00755 WNT7A	9	WNT7A [extracellular region] (R-HSA-517404) N4GlycoAsn-PalmS WNT7A [extracellular exosome] (R-HSA-3781951) N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane] (R-HSA-3781961) WNT7A [endoplasmic reticulum lumen] (R-HSA-3238312) N4GlycoAsn-WNT7A [endoplasmic reticulum lumen] (R-HSA-3238249) N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen] (R-HSA-3238354) N4GlycoAsn-PalmS WNT7A [Golgi lumen] (R-HSA-3247778) N4GlycoAsn-PalmS WNT7A [extracellular region] (R-HSA-3247774) N4GlycoAsn-PalmS WNT7A [plasma membrane] (R-HSA-3247833)	0.527	2
UniProt:O60293 ZC3H1			0.527	2
UniProt:Q9Y228 T3JAM			0.527	3
UniProt:Q9BUL8 PDC10			0.527	2
UniProt:Q75QN2 INTS8	1	INTS8 [nucleoplasm] (R-HSA-6807409)	0.527	2
UniProt:Q8N201 INTS1	1	INTS1 [nucleoplasm] (R-HSA-6807446)	0.527	2
UniProt:Q96E09 PBIR1			0.527	2
UniProt:Q8IYD2 KLD8A			0.527	2
UniProt:Q68E01 INTS3	1	INTS3 [nucleoplasm] (R-HSA-6807435)	0.527	2
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.527	2
UniProt:P68104 EEF1A1	7	EEF1A1 [lysosomal membrane] (R-HSA-9626022) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212)	0.527	3
UniProt:P04020 VE7			0.524	2
UniProt:P46695 IER3	1	IER3 [cytosol] (R-HSA-6811515)	0.524	2
UniProt:P97346 NXN			0.524	2
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.524	2
UniProt:Q14653 IRF3	6	IRF3 [cytosol] (R-HSA-166251) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3(272-427) [cytosol] (R-HSA-9729737) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418)	0.499	4
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.488	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.462	2

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