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PPP2CA [nucleoplasm]
Stable Identifier
R-HSA-165978
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PP2A-catalytic subunit C alpha isoform
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
MASTL Facilitates Mitotic Progression (Homo sapiens)
p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D (Homo sapiens)
PP2A-PPP2R2D [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
p-S62-ARPP19/p-S67-ENSA:PP2A-PPP2R2D [nucleoplasm] (Homo sapiens)
PP2A-PPP2R2D [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Dephosphorylation of p107 (RBL1) by PP2A (Homo sapiens)
PP2A [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)
PP2A [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
E2F mediated regulation of DNA replication (Homo sapiens)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Homo sapiens)
PP2A mediated localization of RB1 protein in chromatin (Homo sapiens)
PP2A [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
PP2A demethylation by PPME1 (Homo sapiens)
PP2A [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
PP2A methylation by LCMT1 (Homo sapiens)
PP2A [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
PP2A-PPP2R2A dephosphorylates FOXM1 (Homo sapiens)
PP2A-PPP2R2A [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)
PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)
PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)
Dephosphorylation of pChREBP (Ser 556) by PP2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Dephosphorylation of pChREBP (Thr 666) by PP2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
PPP2CA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P67775 PPP2CA
Gene Names
PPP2CA
Chain
chain:1-309
Reference Genes
BioGPS Gene:5515 PPP2CA
COSMIC (genes):PPP2CA PPP2CA
CTD Gene:5515 PPP2CA
dbSNP Gene:5515 PPP2CA
ENSEMBL:ENSG00000113575 PPP2CA
ENSEMBL_homo_sapiens_GENE:ENSG00000113575.12 PPP2CA
HGNC:9299 PPP2CA
KEGG Gene (Homo sapiens):5515 PPP2CA
Monarch:5515 PPP2CA
NCBI Gene:5515 PPP2CA
OMIM:176915 PPP2CA
UCSC:P67775 PPP2CA
Reference Transcript
RefSeq:NM_002715.2 PPP2CA
Other Identifiers
11715804_s_at
11715805_a_at
11758731_at
17000022
208652_PM_at
208652_at
235502_PM_at
235502_at
237_s_at
238719_PM_at
238719_at
2876044
2876045
2876047
2876048
2876049
2876050
2876051
2876052
2876053
2876054
2876055
2876056
2876058
2876060
2876061
2876062
2876066
2876067
2876075
2876076
2876077
2876078
33181_at
48243_at
54851_at
5515
8114158
A_23_P122041
GE57999
GO:0000159
GO:0000278
GO:0000775
GO:0000922
GO:0001932
GO:0002376
GO:0003824
GO:0004721
GO:0004722
GO:0004725
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0005856
GO:0005886
GO:0005975
GO:0006091
GO:0006260
GO:0006275
GO:0006351
GO:0006355
GO:0006470
GO:0006629
GO:0006672
GO:0006915
GO:0007155
GO:0007498
GO:0008092
GO:0008380
GO:0010033
GO:0010288
GO:0010719
GO:0012501
GO:0015630
GO:0016020
GO:0016787
GO:0017018
GO:0019932
GO:0022414
GO:0023052
GO:0030111
GO:0030154
GO:0030155
GO:0030308
GO:0035970
GO:0036211
GO:0040008
GO:0042532
GO:0043029
GO:0043226
GO:0045121
GO:0045202
GO:0045595
GO:0046872
GO:0046982
GO:0048156
GO:0048856
GO:0050811
GO:0051321
GO:0051898
GO:0055086
GO:0065003
GO:0070062
GO:0070262
GO:0071902
GO:0140096
GO:1900227
GO:1901135
GO:1904526
GO:1904528
GO:1904539
GO:2000045
HMNXSV003012706
Hs.102243.0.A1_3p_at
Hs.102243.0.A1_3p_x_at
Hs.79204.0.S1_3p_at
ILMN_1722858
ILMN_2196097
M60483_rna1_s_at
PH_hs_0005098
TC05003406.hg
g12653262_3p_at
Participates
as a candidate of
PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
Other forms of this molecule
MeL-PPP2CA [nucleoplasm]
p-Y307-PPP2CA [cytosol]
PPP2CA [cytosol]
Inferred To
ppp2caa [nucleoplasm]
(Danio rerio)
ppp2ca [nucleoplasm]
(Xenopus tropicalis)
PPP2CA [nucleoplasm]
(Bos taurus)
PPP2CA [nucleoplasm]
(Caenorhabditis elegans)
PPP2CA [nucleoplasm]
(Canis familiaris)
PPP2CA [nucleoplasm]
(Dictyostelium discoideum)
PPP2CA [nucleoplasm]
(Drosophila melanogaster)
PPP2CA [nucleoplasm]
(Gallus gallus)
PPP2CA [nucleoplasm]
(Mus musculus)
PPP2CA [nucleoplasm]
(Rattus norvegicus)
PPP2CA [nucleoplasm]
(Saccharomyces cerevisiae)
PPP2CA [nucleoplasm]
(Schizosaccharomyces pombe)
PPP2CA [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_002706.1
Guide to Pharmacology - Targets
3263
OpenTargets
ENSG00000113575
GeneCards
P67775
HPA
ENSG00000113575-PPP2CA
Ensembl
ENSP00000418447
,
ENSG00000113575
,
ENST00000481195
ZINC target
P67775
PRO
P67775
Pharos - Targets
P67775
HMDB Protein
HMDBP02514
PDB
7SOY
,
2NYM
,
3P71
,
3C5W
,
8TTB
,
4I5N
,
7PKS
,
4LAC
,
2NYL
,
4I5L
,
8RBX
,
7CUN
,
8SO0
,
4NY3
,
3DW8
,
6NTS
,
8TWE
,
8U89
,
2IE3
,
2NPP
,
4IYP
,
8RBZ
,
3K7V
,
8RC4
,
3K7W
,
7YCX
,
5W0W
,
8UWB
,
2IAE
,
2IE4
,
3FGA
,
8TWI
,
8U1X
,
7K36
Interactors (113)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30153 PPP2R1A
2
PPP2R1A [nucleoplasm]
(R-HSA-165968)
PPP2R1A [cytosol]
(R-HSA-165982)
0.984
50
UniProt:P78318 IGBP1
0.959
20
UniProt:Q13362 PPP2R5C
3
PPP2R5C [nucleoplasm]
(R-HSA-3008946)
p-S337-PPP2R5C [cytosol]
(R-HSA-6811447)
PPP2R5C [cytosol]
(R-HSA-3008954)
0.934
11
UniProt:P30154 PPP2R1B
2
PPP2R1B [cytosol]
(R-HSA-165980)
PPP2R1B [nucleoplasm]
(R-HSA-166000)
0.919
9
UniProt:P63151 PPP2R2A
2
PPP2R2A [nucleoplasm]
(R-HSA-1564978)
PPP2R2A [cytosol]
(R-HSA-377253)
0.915
12
UniProt:Q15173 PPP2R5B
2
p-S368-PPP2R5B [cytosol]
(R-HSA-6811453)
PPP2R5B [cytosol]
(R-HSA-535469)
0.908
8
UniProt:Q15172 PPP2R5A
2
p-S28-PPP2R5A [cytosol]
(R-HSA-9836658)
PPP2R5A [cytosol]
(R-HSA-196235)
0.903
8
UniProt:Q5VSL9 STRP1
0.899
10
UniProt:Q9Y570 PPME1
1
PPME1 [nucleoplasm]
(R-HSA-8857790)
0.877
9
UniProt:Q13136 PPFIA1
1
PPFIA1 [cytosol]
(R-HSA-383377)
0.864
8
UniProt:Q14738 PPP2R5D
2
PPP2R5D [nucleoplasm]
(R-HSA-3008956)
PPP2R5D [cytosol]
(R-HSA-3008950)
0.864
8
UniProt:Q16537 PPP2R5E
1
PPP2R5E [cytosol]
(R-HSA-1638770)
0.855
7
UniProt:Q5FBB7 SGO1
1
SGOL1 [cytosol]
(R-HSA-376227)
0.848
7
UniProt:Q66LE6 PPP2R2D
1
PPP2R2D [nucleoplasm]
(R-HSA-2160962)
0.848
10
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.84
7
UniProt:Q13033 STRN3
0.831
9
UniProt:Q9Y3A3 PHOCN
0.823
9
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.788
5
UniProt:Q15645 PCH2
0.764
6
UniProt:Q9P2B4 CT2NL
0.758
6
UniProt:P78371 CCT2
3
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [cytosol]
(R-HSA-390464)
0.758
5
UniProt:O75145 PPFIA3
1
PPFIA3 [cytosol]
(R-HSA-383382)
0.758
5
UniProt:Q9NRL3 STRN4
0.758
5
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.758
5
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.756
4
UniProt:Q14BN4 SLMAP
0.745
5
UniProt:Q76MZ3 Ppp2r1a
2
Ppp2r1a [nucleoplasm]
(R-MMU-165968)
PP2A A subunit [cytosol]
(R-MMU-206067)
0.743
4
UniProt:Q9BRV8 SIKE1
1
SIKE1 [cytosol]
(R-HSA-916828)
0.725
5
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.725
4
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.725
4
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.725
4
UniProt:P50990 CCT8
5
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [cytosol]
(R-HSA-390449)
0.725
4
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.725
4
UniProt:Q16204 CCDC6
0.725
4
UniProt:Q9Y2T4 2ABG
0.708
6
UniProt:P22830 FECH
1
FECH [mitochondrial inner membrane]
(R-HSA-189441)
0.671
4
UniProt:Q96CB8 INTS12
1
INTS12 [nucleoplasm]
(R-HSA-6807456)
0.643
3
UniProt:Q9NVR7 TBCC1
0.643
3
UniProt:Q9Y5P8 PPP2R3B
1
PPP2R3B [nucleoplasm]
(R-HSA-3008955)
0.643
3
UniProt:Q9UL03 INTS6
1
INTS6 [nucleoplasm]
(R-HSA-6807440)
0.643
3
UniProt:Q8TF05 PP4R1
0.643
3
UniProt:Q5THK1 PR14L
0.643
3
UniProt:Q13033-2 STRN3
0.643
4
UniProt:Q9P289 STK26
3
MST4(306-416) [cytosol]
(R-HSA-351903)
MST4(1-305) [cytosol]
(R-HSA-351855)
MST4 [cytosol]
(R-HSA-351918)
0.643
4
UniProt:Q9NVK5 FGFR1OP2
2
FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1606443)
FGFR1OP(1-132)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838998)
0.643
4
UniProt:Q96HW7 INTS4
1
INTS4 [nucleoplasm]
(R-HSA-6807462)
0.643
3
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
AXIN1 [cytosol]
(R-HSA-195249)
0.643
4
UniProt:Q06190 P2R3A
0.643
4
UniProt:O00506 STK25
0.643
3
UniProt:Q86XL3 ANKLE2
2
ANKLE2 [endoplasmic reticulum membrane]
(R-HSA-2529000)
Ac-K302-ANKLE2 [endoplasmic reticulum membrane]
(R-HSA-9667946)
0.643
3
UniProt:Q9Y6E0 STK24
4
STK24(1-313) [nucleoplasm]
(R-HSA-351944)
STK24(314-443) [cytosol]
(R-HSA-351898)
STK24(1-313) [cytosol]
(R-HSA-351892)
STK24 [cytosol]
(R-HSA-351829)
0.643
3
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.641
4
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.641
3
UniProt:Q61249 IGBP1
0.602
3
UniProt:P03129 VE7
0.602
3
UniProt:Q00005 2ABB
0.597
5
UniProt:Q14674 ESPL1
4
ESPL1(1-1506) [cytosol]
(R-HSA-2467768)
ESPL1(1507-1535) [cytosol]
(R-HSA-2500272)
ESPL1(1536-2120) [cytosol]
(R-HSA-2467767)
ESPL1 [cytosol]
(R-HSA-1638167)
0.597
3
UniProt:Q969F8 KISS1R
1
KISS1R [plasma membrane]
(R-HSA-388974)
0.593
3
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.591
6
UniProt:O75663 TIPRL
0.589
3
UniProt:Q562F6 SGO2
1
SGOL2 [cytosol]
(R-HSA-376242)
0.564
2
UniProt:Q9UPQ4-2 Q9UPQ42
0.556
3
UniProt:Q5T6F2 UBAP2
0.556
3
IntAct:EBI-22384931 CCSB ORF ID
0.556
3
UniProt:Q16740 CLPP
1
CLPP [mitochondrial matrix]
(R-HSA-9838002)
0.556
3
UniProt:Q08AM6 VAC14
3
VAC14 [Golgi membrane]
(R-HSA-1806235)
VAC14 [early endosome membrane]
(R-HSA-1806207)
VAC14 [late endosome membrane]
(R-HSA-1806219)
0.556
3
UniProt:Q96JM7-2 L3MBTL3
0.556
3
UniProt:Q3SXR2 CC036
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.544
2
UniProt:Q08999 RBL2
2
RBL2 [nucleoplasm]
(R-HSA-389102)
p-T401,S672,S1035-RBL2 [nucleoplasm]
(R-HSA-1226084)
0.544
2
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.544
2
UniProt:Q9NV88 INTS9
1
INTS9 [nucleoplasm]
(R-HSA-6807424)
0.527
2
UniProt:Q9H0H0 INTS2
1
INTS2 [nucleoplasm]
(R-HSA-6807448)
0.527
2
UniProt:Q9BWN1 PRR14
0.527
2
UniProt:Q77M19 Q77M19
0.527
2
UniProt:Q5TA45 CPSF3L
1
CPSF3L [nucleoplasm]
(R-HSA-6807411)
0.527
2
UniProt:Q9NVR2 INTS10
1
INTS10 [nucleoplasm]
(R-HSA-6807420)
0.527
2
UniProt:Q969G9 NKD1
0.527
2
UniProt:Q9NQX6 ZNF331
1
ZNF331 [nucleoplasm]
(R-HSA-1247549)
0.527
3
UniProt:O95684 CEP43
3
FGFR1OP(2-163)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1604533)
FGFR1OP(2-163)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838994)
FGFR1OP [cytosol]
(R-HSA-380309)
0.527
2
UniProt:Q6ZMY9 ZNF517
1
ZNF517 [nucleoplasm]
(R-HSA-1973869)
0.527
2
UniProt:O43638 FOXS1
0.527
2
UniProt:Q8IYG6 LRC56
0.527
2
UniProt:Q96SY0 VWA9
1
VWA9 [nucleoplasm]
(R-HSA-6807412)
0.527
2
UniProt:Q9NVH2 INTS7
1
INTS7 [nucleoplasm]
(R-HSA-6807401)
0.527
2
UniProt:Q12950 FOXD4
0.527
3
UniProt:Q9NUC0 SRTD4
0.527
3
UniProt:P42695 NCAPD3
3
p-T1415,S1419-NCAPD3 [nucleoplasm]
(R-HSA-2294594)
p-T1415-NCAPD3 [nucleoplasm]
(R-HSA-2294587)
NCAPD3 [nucleoplasm]
(R-HSA-1629790)
0.527
2
UniProt:Q8NC26 ZNF114
1
ZNF114 [nucleoplasm]
(R-HSA-975026)
0.527
2
UniProt:Q96H86 ZNF764
1
ZNF764 [nucleoplasm]
(R-HSA-3343766)
0.527
2
UniProt:Q9BXL8 CDCA4
0.527
4
UniProt:Q92974 ARHGEF2
1
ARHGEF2 [cytosol]
(R-HSA-195101)
0.527
2
UniProt:Q7Z398 ZNF550
1
ZNF550 [nucleoplasm]
(R-HSA-1973896)
0.527
2
UniProt:Q6P9B9 INTS5
1
INTS5 [nucleoplasm]
(R-HSA-6807418)
0.527
2
UniProt:O00755 WNT7A
9
WNT7A [extracellular region]
(R-HSA-517404)
N4GlycoAsn-PalmS WNT7A [extracellular exosome]
(R-HSA-3781951)
N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane]
(R-HSA-3781961)
WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238312)
N4GlycoAsn-WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238249)
N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238354)
N4GlycoAsn-PalmS WNT7A [Golgi lumen]
(R-HSA-3247778)
N4GlycoAsn-PalmS WNT7A [extracellular region]
(R-HSA-3247774)
N4GlycoAsn-PalmS WNT7A [plasma membrane]
(R-HSA-3247833)
0.527
2
UniProt:O60293 ZC3H1
0.527
2
UniProt:Q9Y228 T3JAM
0.527
3
UniProt:Q9BUL8 PDC10
0.527
2
UniProt:Q75QN2 INTS8
1
INTS8 [nucleoplasm]
(R-HSA-6807409)
0.527
2
UniProt:Q8N201 INTS1
1
INTS1 [nucleoplasm]
(R-HSA-6807446)
0.527
2
UniProt:Q96E09 PBIR1
0.527
2
UniProt:Q8IYD2 KLD8A
0.527
2
UniProt:Q68E01 INTS3
1
INTS3 [nucleoplasm]
(R-HSA-6807435)
0.527
2
UniProt:P62714 PPP2CB
4
MeL-PPP2CB [nucleoplasm]
(R-HSA-8857799)
p-Y307-PPP2CB [cytosol]
(R-HSA-8857935)
PPP2CB [nucleoplasm]
(R-HSA-165991)
PPP2CB [cytosol]
(R-HSA-165987)
0.527
2
UniProt:P68104 EEF1A1
7
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
0.527
3
UniProt:P04020 VE7
0.524
2
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.524
2
UniProt:P97346 NXN
0.524
2
UniProt:P46695 IER3
1
IER3 [cytosol]
(R-HSA-6811515)
0.524
2
UniProt:Q14653 IRF3
6
p-5S,T404-IRF3 [nucleoplasm]
(R-HSA-936418)
p-4S,T404-IRF3 [nucleoplasm]
(R-HSA-177654)
p-4S,T404-IRF3 [cytosol]
(R-HSA-166258)
IRF3(272-427) [cytosol]
(R-HSA-9729737)
IRF3(2-271) [cytosol]
(R-HSA-9729696)
IRF3 [cytosol]
(R-HSA-166251)
0.499
4
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.488
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.462
2
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