Reactome | Synthesis of PIPs at the plasma membrane

Synthesis of PIPs at the plasma membrane

Stable Identifier

R-HSA-1660499

DOI

10.3180/R-HSA-1660499.5

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Synthesis of PIPs at the plasma membrane

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At the plasma membrane, subsequent phosphorylation of phosphatidylinositol 4-phosphate (PI4P) produces phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) while the actions of various other kinases and phosphatases produces phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 5-phosphate (PI5P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Zhang et al. 1997, Gurung et al. 2003, Guo et al. 1999, Vanhaesebroeck et al. 1997, Tolias et al. 1998, Schaletzky et al. 2003, Kim et al. 2002, Clarke et al. 2010). Many of the phosphatidylinositol phosphatases that act at the plasma membrane belong to the myotubularin family. Enzymatically inactive myotubularin family members can heterodimerize with catalytically active mytotubularins to regulate their stability, activity and/or substrate specificity (Berger et al. 2006, Zou et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
16399794	Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2 Volkmer, B, Berger, I, Tersar, K, Berger, P, Suter, U, Schaffitzel, C	Hum. Mol. Genet.	2006
11733541	Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease Taylor, GS, Torgersen, KM, Kim, SA, Dixon, JE	J Biol Chem	2002
10224048	SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases Lemrow, SM, Guo, S, Stolz, LE, York, JD	J Biol Chem	1999
22647598	Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8 Marjanovic, J, Majerus, PW, Kisseleva, MV, Wilson, MP, Zhang, C, Zou, J	Proc. Natl. Acad. Sci. U.S.A.	2012
12646134	Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases Lorenzo, O, Short, B, Barr, FA, Schaletzky, J, Clague, MJ, Dove, SK	Curr Biol	2003
19896968	Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases Wang, M, Irvine, RF, Clarke, JH	Adv Enzyme Regul	2010
12536145	Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation Tan, A, Prescott, M, Munday, AD, Mitchell, CA, McGrath, MJ, Gurung, R, Whisstock, JC, Huysmans, RD, Ooms, LM	J Biol Chem	2003
9660759	Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate Rameh, LE, Cantley, LC, Ishihara, H, Shibasaki, Y, Prestwich, GD, Carpenter, CL, Chen, J, Tolias, KF	J Biol Chem	1998
9211928	Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules Thum, O, Majerus, PW, Parker, GJ, Boronenkov, IV, Zhang, X, Prestwich, GD, Anderson, RA, Loijens, JC, Chen, J, Norris, FA	J Biol Chem	1997
9113989	P110delta, a novel phosphoinositide 3-kinase in leukocytes Downward, J, Higashi, K, Waterfield, MD, Volinia, S, Stein, R, Vanhaesebroeck, B, Warne, PH, Zvelebil, MJ, Kotani, K, Welham, MJ	Proc Natl Acad Sci U S A	1997