Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
IRAK4 [cytosol]
Stable Identifier
R-HSA-166081
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
IRAK4 is activated by autophosphorylation (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
The Interleukin 1 receptor complex binds Tollip (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Homo sapiens)
hp-IRAK1:Pellino, IRAK4:Pellino [cytosol] (Homo sapiens)
IRAK4: Pellino-1,2,3 [cytosol] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
hp-IRAK1:p-Pellino, IRAK4:p-Pellino [cytosol] (Homo sapiens)
IRAK4: p-Pellino-1,2,3 [cytosol] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Homo sapiens)
hp-IRAK1:Pellino, IRAK4:Pellino [cytosol] (Homo sapiens)
IRAK4: Pellino-1,2,3 [cytosol] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
p-2S,S376,T,T209,T387-IRAK1, IRAK4 [cytosol] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Homo sapiens)
IRAK1:Pellino:E2 complexes [cytosol] (Homo sapiens)
IRAK4: p-Pellino-1,2,3:UBE2N:UBE2V1:K63polyUb [cytosol] (Homo sapiens)
IRAK4: p-Pellino-1,2,3 [cytosol] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
hp-IRAK1:p-Pellino, IRAK4:p-Pellino [cytosol] (Homo sapiens)
IRAK4: p-Pellino-1,2,3 [cytosol] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
IRAK4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NWZ3 IRAK4
Gene Names
IRAK4
Chain
chain:1-460
Reference Genes
BioGPS Gene:51135 IRAK4
COSMIC (genes):IRAK4 IRAK4
CTD Gene:51135 IRAK4
dbSNP Gene:51135 IRAK4
ENSEMBL:ENSG00000198001 IRAK4
ENSEMBL:ENSG00000198001.16 IRAK4
HGNC:17967 IRAK4
KEGG Gene (Homo sapiens):51135 IRAK4
Monarch:51135 IRAK4
NCBI Gene:51135 IRAK4
OMIM:606883 IRAK4
UCSC:Q9NWZ3 IRAK4
Reference Transcript
RefSeq:XM_017019391.1 IRAK4
RefSeq:XM_017019390.1 IRAK4
RefSeq:XM_011538433.2 IRAK4
RefSeq:XM_011538432.1 IRAK4
RefSeq:XM_011538431.2 IRAK4
RefSeq:XM_006719439.2 IRAK4
RefSeq:XM_006719438.3 IRAK4
RefSeq:XM_005268949.2 IRAK4
RefSeq:XM_005268948.2 IRAK4
RefSeq:XM_005268947.4 IRAK4
RefSeq:XM_005268945.4 IRAK4
RefSeq:XM_005268944.4 IRAK4
RefSeq:XM_005268943.3 IRAK4
RefSeq:NM_016123.3 IRAK4
RefSeq:NM_001145258.1 IRAK4
RefSeq:NM_001145257.1 IRAK4
RefSeq:NM_001145256.1 IRAK4
RefSeq:NM_001114182.2 IRAK4
Other Identifiers
11734066_x_at
11734067_a_at
11740649_a_at
11742042_a_at
16750277
219618_3p_at
219618_PM_at
219618_at
3412297
3412299
3412302
3412306
3412307
3412308
3412309
3412311
3412316
3412317
3412318
3412320
3412321
3412322
3412323
3412324
3412325
3412326
3412327
3412328
3412329
3412330
51135
7954969
81368_at
A_23_P13978
A_24_P158903
GE58687
GE595587
GO:0000166
GO:0000287
GO:0002224
GO:0002376
GO:0002446
GO:0002755
GO:0003824
GO:0004672
GO:0004674
GO:0005149
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0006468
GO:0007165
GO:0007254
GO:0009986
GO:0010008
GO:0016301
GO:0016310
GO:0016740
GO:0019209
GO:0019221
GO:0019897
GO:0019901
GO:0023052
GO:0031349
GO:0031410
GO:0032103
GO:0034162
GO:0035556
GO:0036211
GO:0043123
GO:0043226
GO:0045087
GO:0048661
GO:0048870
GO:0070498
GO:0071310
GO:0098542
GO:0098772
GO:0106310
GO:0140096
GO:1990266
HMNXSV003043621
ILMN_1692352
TC12000325.hg
g7705840_3p_x_at
Participates
as an input of
IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Homo sapiens)
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
as a member of
p-2S,S376,T,T209,T387-IRAK1, IRAK4 [cytosol] (Homo sapiens)
as a component of
IRAK4: p-Pellino-1,2,3 [cytosol] (Homo sapiens)
IRAK4: Pellino-1,2,3 [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
Other forms of this molecule
IRAK4 R12C [cytosol]
IRAK4 Q293TER [cytosol]
IRAK4 E402TER [cytosol]
p-T342,T345,S346-IRAK4 [cytosol]
IRAK4 [endosome membrane]
p-T342,T345,S346-IRAK4 [endosome membrane]
IRAK4 [plasma membrane]
p-T342,T345,S346-IRAK4 [plasma membrane]
Inferred To
Ghost homologue of IRAK4 [cytosol]
(Xenopus tropicalis)
Homologues of IRAK4 [cytosol]
(Saccharomyces cerevisiae)
IRAK4 [cytosol]
(Bos taurus)
IRAK4 [cytosol]
(Caenorhabditis elegans)
IRAK4 [cytosol]
(Canis familiaris)
IRAK4 [cytosol]
(Danio rerio)
IRAK4 [cytosol]
(Dictyostelium discoideum)
IRAK4 [cytosol]
(Drosophila melanogaster)
IRAK4 [cytosol]
(Gallus gallus)
IRAK4 [cytosol]
(Mus musculus)
IRAK4 [cytosol]
(Rattus norvegicus)
IRAK4 [cytosol]
(Saccharomyces cerevisiae)
IRAK4 [cytosol]
(Schizosaccharomyces pombe)
IRAK4 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001138729.1
,
XP_011536735.1
,
NP_001107654.1
,
NP_001138728.1
,
XP_011536734.1
,
XP_005269000.1
,
NP_001138730.1
,
XP_016874879.1
,
XP_005269002.1
,
XP_006719501.1
,
XP_006719502.1
,
NP_057207.2
,
XP_005269004.1
,
XP_011536733.1
,
XP_016874880.1
,
XP_005269005.1
,
XP_005269006.1
,
XP_005269001.1
ZINC - World Drugs
IRAK4_HUMAN
Guide to Pharmacology - Targets
2045
OpenTargets
ENSG00000198001
ZINC - FDA approved
IRAK4_HUMAN
ZINC - Substances
IRAK4_HUMAN
ZINC - Biogenic
IRAK4_HUMAN
ZINC target
Q9NWZ3
PRO
Q9NWZ3
PDB
5W85
,
6F3G
,
3MOP
,
4U9A
,
4ZTM
,
4ZTN
,
6F3I
,
6THZ
,
5UIQ
,
2OIC
,
2O8Y
,
5UIS
,
5UIT
,
7QG1
,
6O94
,
5T1S
,
6RFI
,
7C2W
,
8DKS
,
6EG9
,
4XS2
,
5K7G
,
5KX7
,
6THW
,
2NRY
,
6F3D
,
4U97
,
6N8G
,
4RMZ
,
6EGA
,
6F3E
,
5W84
,
5K7I
,
4ZTL
,
4YO6
,
5K72
,
7C2V
,
6EGD
,
5K75
,
6MOM
,
4Y73
,
2OIB
,
5UIR
,
7QG2
,
5K76
,
6O8U
,
6EGE
,
6TI8
,
2OID
,
6EGF
,
6UYA
,
5T1T
,
6LXY
,
6RFJ
,
7QG5
,
6TIA
,
6O95
,
5UIU
,
5KX8
,
4YP8
,
2NRU
,
7QG3
,
6THX
,
6VQL
,
6O9D
ZINC - Investigational
IRAK4_HUMAN
HPA
ENSG00000198001-IRAK4
GeneCards
Q9NWZ3
Ensembl
ENST00000551736
,
ENST00000440781
,
ENSP00000479889
,
ENST00000613694
,
ENSG00000198001
,
ENSP00000408734
,
ENSP00000446490
Pharos - Targets
Q9NWZ3
ZINC - Predictions - Purchasable
IRAK4_HUMAN
Orphanet
16266
HMDB Protein
HMDBP01466
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.922
15
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.775
6
UniProt:Q99836-1 MYD88
0.75
9
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.711
6
UniProt:Q9HAT8 PELI2
2
PELI2 [cytosol]
(R-HSA-450694)
p-PELI2 [cytosol]
(R-HSA-450825)
0.593
3
UniProt:Q96LX8 ZNF597
1
ZNF597 [nucleoplasm]
(R-HSA-2127591)
0.556
3
UniProt:Q9C029 TRIM7
0.556
3
UniProt:Q9UBH0 IL36RN
1
IL36RN [extracellular region]
(R-HSA-8940995)
0.556
3
UniProt:P51617 IRAK1
14
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
IRAK1 [cytosol]
(R-HSA-446639)
0.547
2
UniProt:P58753 TIRAP
2
TIRAP [cytosol]
(R-HSA-166141)
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
0.499
2
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.462
4
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text