Reactome | IRAK4 [cytosol]

IRAK4 [cytosol]

Stable Identifier

R-HSA-166081

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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External Reference Information

External Reference

UniProt:Q9NWZ3 IRAK4

Gene Names

IRAK4

Chain

chain:1-460

Reference Genes

BioGPS Gene:51135 IRAK4

COSMIC (genes):IRAK4 IRAK4

CTD Gene:51135 IRAK4

dbSNP Gene:51135 IRAK4

ENSEMBL:ENSG00000198001 IRAK4

HGNC:17967 IRAK4

KEGG:hsa:51135 IRAK4

Monarch:51135 IRAK4

NCBI Gene:51135 IRAK4

OMIM:606883 IRAK4

UCSC:Q9NWZ3 IRAK4

Reference Transcript

Other Identifiers

11734066_x_at

11734067_a_at

11740649_a_at

11742042_a_at

16750277

219618_3p_at

219618_PM_at

219618_at

3412297

3412298

3412299

3412302

3412303

3412304

3412306

3412307

3412308

3412309

3412311

3412312

3412313

3412314

3412316

3412317

3412318

3412320

3412321

3412322

3412323

3412324

3412325

3412326

3412327

3412328

3412329

3412330

3412332

3412336

51135

7954969

81368_at

A_14_P122539

A_23_P13978

A_24_P158903

GE58687

GE595587

GO:0000287

GO:0002224

GO:0002376

GO:0002446

GO:0002755

GO:0003824

GO:0004672

GO:0004674

GO:0005149

GO:0005515

GO:0005524

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006468

GO:0006950

GO:0007165

GO:0007166

GO:0007254

GO:0008063

GO:0009986

GO:0010008

GO:0016301

GO:0016740

GO:0019221

GO:0019897

GO:0019901

GO:0031349

GO:0034142

GO:0034162

GO:0035556

GO:0038172

GO:0043123

GO:0043226

GO:0045087

GO:0048661

GO:0048870

GO:0070498

GO:0071222

GO:0098542

GO:0106310

GO:0140096

GO:1990266

HMNXSV003043621

ILMN_1692352

TC12000325.hg

g7705840_3p_x_at

Participates

as a component of

as a member of

p-2S,S376,T,T209,T387-IRAK1, IRAK4 [cytosol] (Homo sapiens)

as an input of

Other forms of this molecule

p-T342,T345,S346-IRAK4 [plasma membrane]

IRAK4 [plasma membrane]

p-T342,T345,S346-IRAK4 [endosome membrane]

IRAK4 [endosome membrane]

p-T342,T345,S346-IRAK4 [cytosol]

IRAK4 E402* [cytosol]

IRAK4 R12C [cytosol]

IRAK4 Q293* [cytosol]

Inferred To

Ghost homologue of IRAK4 [cytosol] (Gallus gallus)

Ghost homologue of IRAK4 [cytosol] (Xenopus tropicalis)

Homologues of IRAK4 [cytosol] (Saccharomyces cerevisiae)

IRAK4 [cytosol] (Bos taurus)

IRAK4 [cytosol] (Caenorhabditis elegans)

IRAK4 [cytosol] (Canis familiaris)

IRAK4 [cytosol] (Dictyostelium discoideum)

IRAK4 [cytosol] (Drosophila melanogaster)

IRAK4 [cytosol] (Mus musculus)

IRAK4 [cytosol] (Rattus norvegicus)

IRAK4 [cytosol] (Saccharomyces cerevisiae)

IRAK4 [cytosol] (Schizosaccharomyces pombe)

IRAK4 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_005269002.1, XP_005269000.1, XP_005269001.1, XP_011536735.1, NP_001107654.1, XP_016874879.1, XP_011536733.1, XP_011536734.1, NP_001138729.1, NP_001138728.1, NP_057207.2, XP_016874880.1, NP_001138730.1, XP_005269004.1, XP_005269005.1, XP_005269006.1, XP_006719502.1, XP_006719501.1

Guide to Pharmacology - Targets

2045

OpenTargets

ENSG00000198001

ENSEMBL

ENST00000440781, ENSP00000446490, ENSP00000408734, ENSG00000198001, ENST00000551736, ENST00000613694, ENSP00000479889

ZINC - FDA approved

IRAK4_HUMAN

ZINC - Substances

IRAK4_HUMAN

ZINC - Biogenic

IRAK4_HUMAN

ZINC target

Q9NWZ3

PRO

Q9NWZ3

GlyGen

Q9NWZ3

PDB

8DKS, 8ATL, 5T1T, 7C2V, 8W3W, 6EGE, 6VQL, 4RMZ, 4Y73, 5UIT, 6THZ, 6EGA, 5T1S, 5K7I, 4YO6, 8V1O, 2OIC, 4U97, 6THX, 7QG1, 7QG2, 8TVN, 6EGD, 6TIA, 8WTF, 4ZTN, 6TI8, 6F3G, 6N8G, 2O8Y, 4U9A, 8BR7, 5W85, 5W84, 6UYA, 6O94, 2OID, 2NRU, 6RFI, 5K75, 5K76, 8TX0, 6MOM, 4XS2, 6F3E, 8ATN, 8V2L, 6THW, 6F3D, 6EG9, 8V2F, 7QG5, 5UIS, 5UIR, 5UIQ, 6LXY, 6RFJ, 2OIB, 6EGF, 6F3I, 7C2W, 5UIU, 8TVM, 3MOP, 4YP8, 7QG3, 8W3X, 6O9D, 2NRY, 8ATB, 8UCB, 8UCC, 6O8U, 5K7G, 6O95, 8BR5, 8BR6, 4ZTL, 5KX8, 4ZTM, 5K72, 5KX7

ZINC - Investigational

IRAK4_HUMAN

HPA

ENSG00000198001-IRAK4

GeneCards

IRAK4

Pharos - Targets

Q9NWZ3

Orphanet

IRAK4

ZINC - Predictions - Purchasable

IRAK4_HUMAN

HMDB Protein

HMDBP01466

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99836 MYD88	8	MYD88 [cytosol] (R-HSA-166059) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [endosome membrane] (R-HSA-975123) MyD88 E65del [cytosol] (R-HSA-5602598) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 R196C [cytosol] (R-HSA-5602329)	0.922	15
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.775	6
UniProt:Q99836-1 MYD88			0.75	9
UniProt:O43187 IRAK2	6	IRAK2 [endosome membrane] (R-HSA-975116) p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.711	6
UniProt:Q9HAT8 PELI2	2	PELI2 [cytosol] (R-HSA-450694) p-PELI2 [cytosol] (R-HSA-450825)	0.593	3
UniProt:P0DPA2 VSIG8			0.589	2
UniProt:Q9UBH0 IL36RN	1	IL36RN [extracellular region] (R-HSA-8940995)	0.556	3
UniProt:Q9C029 TRIM7			0.556	3
UniProt:Q96LX8 ZNF597	1	ZNF597 [nucleoplasm] (R-HSA-2127591)	0.556	3
UniProt:P51617 IRAK1	14	IRAK1 [cytosol] (R-HSA-446639) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) IRAK1 [plasma membrane] (R-HSA-937045) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [endosome membrane] (R-HSA-975127) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687)	0.547	2
UniProt:P58753 TIRAP	2	p-4Y-TIRAP [plasma membrane] (R-HSA-2201321) TIRAP [cytosol] (R-HSA-166141)	0.499	2
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.462	4

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