IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane]

Stable Identifier
R-HSA-166100
Type
Complex
Species
Homo sapiens
Related Species
Chlamydia trachomatis, Neisseria meningitidis serogroup B
Compartment
plasma membrane
Synonyms
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:Mal:activated TLR
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
11544529 Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Jefferies, CA, O'Neill, LA, Mansell, AS, Bird, TA, Brint, E, Smith, DE, Gray, P, Sims, JE, Palsson-McDermott, EM, Bowie, AG, Harte, MT, Fitzgerald, KA, McMurray, D, Dunne, A, Brady, G

Nature 2001
19679662 Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases

Ruggiero, V, Gallo, G, Fantò, N, Loiarro, M, De Santis, R, Carminati, P, Sette, C

J Biol Chem 2009
20485341 Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling

Lo, YC, Lin, SC, Wu, H

Nature 2010
20400509 IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)

Brikos, C, Wesche, H, O'Neill, LA, Gray, P, Morrice, N, Strelow, A, Carpenter, S, Dunne, A

J. Biol. Chem. 2010
Participants
components
Participates
as an output of
Inferred To
IRAK2 : p-IRAK4 :MyD88 : TIRAP : activated TLR [plasma membrane] (Gallus gallus)
IRAK2 : p-IRAK4 :MyD88 : activated TLR [plasma membrane] (Gallus gallus)
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