The activation of arylsulfatases

Stable Identifier
R-HSA-1663150
DOI
10.3180/REACT_121036.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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The activation of arylsulfatases
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Sulfatase activity requires a unique posttranslational modification (PTM) of a catalytic cysteine residue into a formylglycine. This modification is impaired in patients with multiple sulfatase deficiency (MSD) due to defects in the SUMF1 (sulfatase-modifying factor 1) gene responsible for this PTM. SUMF2 can inhibit the activity of SUMF1 thereby providing a mechanism for the regulation of sulfatase activation (Ghosh 2007, Diez-Roux & Ballabio 2005).
Literature References
PubMed ID Title Journal Year
17558559 Human sulfatases: a structural perspective to catalysis

Ghosh, D

Cell Mol Life Sci 2007
16124866 Sulfatases and human disease

Diez-Roux, G, Ballabio, A

Annu Rev Genomics Hum Genet 2005
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Orthologous Events
The activation of arylsulfatases (Bos taurus)
The activation of arylsulfatases (Canis familiaris)
The activation of arylsulfatases (Gallus gallus)
The activation of arylsulfatases (Mus musculus)
The activation of arylsulfatases (Rattus norvegicus)
The activation of arylsulfatases (Sus scrofa)
The activation of arylsulfatases (Xenopus tropicalis)
Authored
Jassal, B  (2011-10-14)
Reviewed
D'Eustachio, P  (2012-05-14)
Created
Jassal, B  (2011-10-14)
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