Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TRAF6 [cytosol]
Stable Identifier
R-HSA-166366
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser for interactor UniProt:Q86VP1 TAX1BP1
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Translocation of TRAF6 to CBM complex (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
IRAK1 induces oligomerisation of TRAF6 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
p62:MEKK3 binds to TRAF6 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Alpha-protein kinase 1 signaling pathway (Homo sapiens)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
TRAF6 binds MALT1 oligomers (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 oligomerizes (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
Oligomerization of TRAF6 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
IRAK2 mediated activation of TAK1 complex (Homo sapiens)
IRAK2 induces TRAF6 oligomerization (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
IRAK2 mediated activation of TAK1 complex (Homo sapiens)
IRAK2 induces TRAF6 oligomerization (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
IRAK2 mediated activation of TAK1 complex (Homo sapiens)
IRAK2 induces TRAF6 oligomerization (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1,TRAF6-dependent induction of TAK1 complex (Homo sapiens)
Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Homo sapiens)
Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
IRAK2 mediated activation of TAK1 complex (Homo sapiens)
IRAK2 induces TRAF6 oligomerization (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
IRAK2 mediated activation of TAK1 complex (Homo sapiens)
IRAK2 induces TRAF6 oligomerization (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Regulated proteolysis of p75NTR (Homo sapiens)
p75NTR ICD signals to NF-kB (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
IRAK interacts with TRAF6 (Homo sapiens)
TRAF6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y4K3 TRAF6
Gene Names
TRAF6, RNF85
Chain
chain:1-522
Reference Genes
BioGPS Gene:7189 TRAF6
COSMIC (genes):TRAF6 TRAF6
CTD Gene:7189 TRAF6
dbSNP Gene:7189 TRAF6
ENSEMBL:ENSG00000175104 TRAF6
ENSEMBL_homo_sapiens_GENE:ENSG00000175104.15 TRAF6
HGNC:12036 TRAF6
KEGG Gene (Homo sapiens):7189 TRAF6
Monarch:7189 TRAF6
NCBI Gene:7189 TRAF6
OMIM:602355 TRAF6
UCSC:Q9Y4K3 TRAF6
Reference Transcript
RefSeq:NM_145803.2 TRAF6
RefSeq:NM_004620.3 TRAF6
Other Identifiers
11744243_a_at
1209_at
16737401
205558_PM_at
205558_at
227264_PM_at
227264_at
3290612
3290616
3369887
3369889
3369891
3369892
3369893
3369894
3369895
3369896
3369898
3369899
3369902
3369903
3369904
3369905
3369906
3369907
3369913
3369914
53334_at
61369_at
7189
74236_at
7947540
82386_at
A_23_P75921
A_32_P192984
GE59433
GO:0000045
GO:0000122
GO:0000209
GO:0001503
GO:0001701
GO:0001843
GO:0002223
GO:0002376
GO:0002637
GO:0002726
GO:0002753
GO:0002755
GO:0003824
GO:0004842
GO:0005164
GO:0005515
GO:0005634
GO:0005737
GO:0005768
GO:0005811
GO:0005829
GO:0005886
GO:0005938
GO:0006351
GO:0006355
GO:0006914
GO:0006955
GO:0006974
GO:0007155
GO:0007165
GO:0007249
GO:0007250
GO:0008270
GO:0009887
GO:0009898
GO:0010008
GO:0012501
GO:0016567
GO:0016740
GO:0019886
GO:0019899
GO:0023052
GO:0030154
GO:0030316
GO:0031234
GO:0031398
GO:0031410
GO:0031624
GO:0031625
GO:0031663
GO:0031666
GO:0032147
GO:0032481
GO:0032735
GO:0032743
GO:0032755
GO:0032813
GO:0032991
GO:0033209
GO:0034138
GO:0034142
GO:0034450
GO:0035556
GO:0035631
GO:0035666
GO:0036211
GO:0038061
GO:0038095
GO:0038172
GO:0038173
GO:0042088
GO:0042102
GO:0042475
GO:0042802
GO:0042826
GO:0042981
GO:0043011
GO:0043122
GO:0043123
GO:0043226
GO:0043422
GO:0043507
GO:0045087
GO:0045453
GO:0045672
GO:0045892
GO:0045944
GO:0046849
GO:0046872
GO:0048468
GO:0048471
GO:0048584
GO:0048856
GO:0050852
GO:0051091
GO:0051092
GO:0051865
GO:0061630
GO:0070498
GO:0070534
GO:0070555
GO:0071222
GO:0071345
GO:0097400
GO:0098542
GO:0140096
GO:0140374
GO:1904996
GO:2000679
HMNXSV003018702
Hs.296272.0.A1_3p_at
ILMN_1700353
ILMN_1783910
ILMN_2392143
PH_hs_0005066
PH_hs_0037121
TC11001560.hg
TC11003120.hg
U78798_at
g4759253_3p_at
Participates
as a component of
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Homo sapiens)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Homo sapiens)
hp-IRAK1:3xTRAF6 [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Homo sapiens)
TRAF6 homotrimer [cytosol] (Homo sapiens)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Homo sapiens)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Homo sapiens)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Homo sapiens)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Homo sapiens)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Homo sapiens)
MEKK1:activated TRAF6 [cytosol] (Homo sapiens)
MALT1oligomer:TRAF6 [cytosol] (Homo sapiens)
as an input of
TRAF6 binds to p-IRAK2 (Homo sapiens)
IRAK1 induces oligomerisation of TRAF6 (Homo sapiens)
Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)
p62:MEKK3 binds to TRAF6 (Homo sapiens)
p75NTR ICD signals to NF-kB (Homo sapiens)
TRAF6 oligomerizes (Homo sapiens)
IRAK2 induces TRAF6 oligomerization (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Homo sapiens)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Homo sapiens)
Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 (Homo sapiens)
Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
Translocation of TRAF6 to CBM complex (Homo sapiens)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)
IRAK interacts with TRAF6 (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Homo sapiens)
Oligomerization of TRAF6 (Homo sapiens)
TRAF6 binds MALT1 oligomers (Homo sapiens)
as a member of
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Homo sapiens)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Homo sapiens)
TRAF2, TRAF6 [cytosol] (Homo sapiens)
as a repeated unit of
TRAF6 oligomer [cytosol] (Homo sapiens)
Other forms of this molecule
K48polyUb-TRAF6 [cytosol]
PolyUb-TRAF6 [cytosol]
TRAF6 [endosome membrane]
K63polyUb-TRAF6 [endosome membrane]
K63polyUb-TRAF6 [cytosol]
K63polyUb-TRAF6 [plasma membrane]
TRAF6 [plasma membrane]
Inferred To
Traf6 [cytosol]
(Drosophila melanogaster)
Traf6 [cytosol]
(Mus musculus)
Traf6 [cytosol]
(Rattus norvegicus)
TRAF6 [cytosol]
(Bos taurus)
TRAF6 [cytosol]
(Canis familiaris)
TRAF6 [cytosol]
(Danio rerio)
TRAF6 [cytosol]
(Gallus gallus)
TRAF6 [cytosol]
(Sus scrofa)
Ghost homologue of TRAF6 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of TRAF6 [cytosol]
(Dictyostelium discoideum)
Ghost homologue of TRAF6 [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of TRAF6 [cytosol]
(Schizosaccharomyces pombe)
traf6 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_665802.1
,
NP_004611.1
OpenTargets
ENSG00000175104
IntEnz
2.3.2.27
GeneCards
Q9Y4K3
HPA
ENSG00000175104-TRAF6
Ensembl
ENSP00000433623
,
ENSP00000337853
,
ENSG00000175104
,
ENST00000348124
,
ENST00000526995
PRO
Q9Y4K3
Pharos - Targets
Q9Y4K3
Orphanet
21836
PDB
3HCS
,
2JMD
,
1LB4
,
3HCT
,
7L3L
,
3HCU
,
5ZUJ
,
4Z8M
,
6A33
,
2ECI
,
1LB6
,
1LB5
,
8HZ2
Interactors (77)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.939
20
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.919
11
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.905
10
UniProt:O00463 TRAF5
0.879
15
UniProt:P61088 UBE2N
5
Ub-C87-UBE2N [nucleoplasm]
(R-HSA-8943013)
K63polyUb-C87-UBE2N [nucleoplasm]
(R-HSA-6790511)
UBE2N [nucleoplasm]
(R-HSA-5682541)
Ub-C87-UBE2N [cytosol]
(R-HSA-8864210)
UBE2N [cytosol]
(R-HSA-206072)
0.847
9
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.809
5
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.797
8
UniProt:P51617 IRAK1
14
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
IRAK1 [cytosol]
(R-HSA-446639)
0.77
4
IntAct:EBI-4399559 UBIQ
0.77
5
UniProt:P62195 PSMC5
2
PSMC5 [nucleoplasm]
(R-HSA-174312)
PSMC5 [cytosol]
(R-HSA-68780)
0.758
4
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.718
6
UniProt:Q8N1B4 VPS52
1
VPS52 [trans-Golgi network membrane]
(R-HSA-6811029)
0.718
6
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.71
4
UniProt:P62837 UBE2D2
4
Ub-C85-UBE2D2 [nucleoplasm]
(R-HSA-8864153)
UBE2D2 [nucleoplasm]
(R-HSA-8852067)
UBE2D2 [cytosol]
(R-HSA-934628)
Ub-C85-UBE2D2 [cytosol]
(R-HSA-8864214)
0.708
5
UniProt:Q96CG3 TIFA
2
TIFA [cytosol]
(R-HSA-451582)
p-T9-TIFA [cytosol]
(R-HSA-9645512)
0.702
6
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.702
3
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.688
4
UniProt:Q9UDY8 MALT1
1
MALT1 [cytosol]
(R-HSA-202461)
0.688
5
UniProt:Q9NYJ8 TAB2
4
TAB2 [cytosol]
(R-HSA-168117)
TAB2 [endosome membrane]
(R-HSA-450279)
TAB2 [plasma membrane]
(R-HSA-168116)
TAB2 [nucleoplasm]
(R-HSA-1253323)
0.678
3
UniProt:Q9Y616 IRAK3
1
IRAK3 [cytosol]
(R-HSA-166103)
0.675
4
UniProt:P09936 UCHL1
1
UCHL1 [cytosol]
(R-HSA-5660679)
0.675
4
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.675
4
UniProt:Q9HAV5 EDA2R
1
EDA2R [plasma membrane]
(R-HSA-5669018)
0.669
3
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
p-MAP3K7 [cytosol]
(R-HSA-168163)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.669
3
UniProt:O43734 CIKS
0.666
4
UniProt:P61077 UBE2D3
3
UBE2D3 [nucleoplasm]
(R-HSA-205341)
UBE2D3 [cytosol]
(R-HSA-934630)
Ub-C85-UBE2D3 [cytosol]
(R-HSA-8864191)
0.658
3
UniProt:Q9UKE5 TNIK
1
TNIK [cytosol]
(R-HSA-3214889)
0.591
3
UniProt:P25942 CD40
0.59
2
UniProt:P07174 Ngfr
8
Ngfr [nucleoplasm]
(R-RNO-197473)
Ngfr [plasma membrane]
(R-RNO-194509)
Ngfr [cytosol]
(R-RNO-194458)
Ngfr [endosome]
(R-RNO-209541)
Ngfr [plasma membrane]
(R-RNO-194476)
Ngfr [extracellular region]
(R-RNO-194470)
Tumor necrosis factor receptor superfamily member 16 [plasma membrane]
(R-RNO-193863)
Ngfr [plasma membrane]
(R-RNO-193664)
0.589
2
UniProt:P28074 PSMB5
4
PSMB5(1-59) [cytosol]
(R-HSA-9908134)
pro-PSMB5 [cytosol]
(R-HSA-9908135)
PSMB5 [nucleoplasm]
(R-HSA-174344)
PSMB5 [cytosol]
(R-HSA-68753)
0.589
2
UniProt:P25786 PSMA1
2
PSMA1 [nucleoplasm]
(R-HSA-174333)
PSMA1 [cytosol]
(R-HSA-68724)
0.589
2
UniProt:Q9UNM6 PSMD13
5
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [cytosol]
(R-HSA-68794)
0.589
2
UniProt:Q15008 PSMD6
5
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [cytosol]
(R-HSA-68804)
0.589
2
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.589
2
UniProt:O00232 PSMD12
5
PSMD12 [secretory granule lumen]
(R-HSA-6800934)
PSMD12 [extracellular region]
(R-HSA-6806480)
PSMD12 [ficolin-1-rich granule lumen]
(R-HSA-6800416)
PSMD12 [nucleoplasm]
(R-HSA-174339)
PSMD12 [cytosol]
(R-HSA-68792)
0.589
2
UniProt:P51665 PSMD7
5
PSMD7 [secretory granule lumen]
(R-HSA-6801008)
PSMD7 [extracellular region]
(R-HSA-6806488)
PSMD7 [ficolin-1-rich granule lumen]
(R-HSA-6800406)
PSMD7 [nucleoplasm]
(R-HSA-174309)
PSMD7 [cytosol]
(R-HSA-68806)
0.589
2
UniProt:P40939 HADHA
1
HADHA [mitochondrial inner membrane]
(R-HSA-77264)
0.589
2
UniProt:P62191 PSMC1
2
PSMC1 [nucleoplasm]
(R-HSA-174338)
PSMC1 [cytosol]
(R-HSA-68768)
0.589
2
UniProt:Q13200 PSMD2
5
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [cytosol]
(R-HSA-68796)
0.589
2
UniProt:Q14257 RCN2
0.589
2
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.556
3
UniProt:Q8IWQ3-3 BRSK2
0.556
3
UniProt:Q9UNA4 POLI
1
POLI [nucleoplasm]
(R-HSA-5656133)
0.556
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.556
3
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.556
3
UniProt:P43405-2 P434052
0.556
3
UniProt:P15732
2
UBC5 [cytosol]
(R-SCE-8864160-2)
UBC5 [cytosol]
(R-SCE-174236-2)
0.556
3
UniProt:Q9HAC8 UBTD1
0.556
3
UniProt:Q8N3F0 MTURN
0.556
3
UniProt:Q8NA54 IQUB
0.556
3
UniProt:Q96DC9 OTUB2
2
OTUB2 [cytosol]
(R-HSA-933410)
OTUB2 [nucleoplasm]
(R-HSA-6783260)
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:Q5VVQ6 YOD1
1
YOD1 [cytosol]
(R-HSA-6781909)
0.556
5
UniProt:P24278 ZBT25
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:O75604 USP2
2
USP2 [cytosol]
(R-HSA-5212661)
USP2 [nucleoplasm]
(R-HSA-5689946)
0.556
3
UniProt:Q8WWZ3 EDARADD
1
EDARADD [cytosol]
(R-HSA-5675659)
0.556
5
UniProt:Q8TD23 ZNF675
1
ZNF675 [nucleoplasm]
(R-HSA-2248874)
0.543
4
UniProt:P99999 CYCS
6
AcK-CYCS [mitochondrial intermembrane space]
(R-HSA-5688308)
Cytochrome c (oxidised) [mitochondrial inner membrane]
(R-HSA-352607)
CYCS [cytosol]
(R-HSA-53259)
CYCS [mitochondrial intermembrane space]
(R-HSA-114244)
apo-CYCS [mitochondrial inner membrane]
(R-HSA-352608)
Cytochrome c (reduced) [mitochondrial inner membrane]
(R-HSA-352609)
0.536
2
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
0.536
2
UniProt:Q9Y3C0 WASC3
0.527
2
UniProt:Q15750 TAB1
6
TAB1(445-504) [cytosol]
(R-HSA-9729691)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1 [cytosol]
(R-HSA-167923)
0.527
2
UniProt:Q9Y2V7 COG6
2
COG6 [Golgi membrane]
(R-HSA-2980958)
COG6 [trans-Golgi network membrane]
(R-HSA-6813872)
0.527
2
UniProt:Q9Y6C2 EMILIN1
1
EMILIN1 [extracellular region]
(R-HSA-2161355)
0.527
2
UniProt:O95721 SNAP29
3
SNAP29 [azurophil granule membrane]
(R-HSA-6799359)
SNAP29 [plasma membrane]
(R-HSA-2029020)
SNAP29 [Golgi membrane]
(R-HSA-6810997)
0.527
3
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.527
2
UniProt:Q05D60 DEUP1
0.527
2
UniProt:P10221 ITP
0.524
3
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.524
2
UniProt:Q01220 A52
0.524
2
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.519
2
UniProt:Q8V2D1 Q8V2D1
0.518
3
UniProt:O75385 ULK1
7
ULK1 [recycling endosome]
(R-HSA-8854761)
p-S758-ULK1 [cytosol]
(R-HSA-5672131)
p-S317,467,556,638,T575-ULK1 [cytosol]
(R-HSA-5673747)
p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
(R-HSA-5675858)
p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
(R-HSA-8948047)
ULK1 [cytosol]
(R-HSA-1632847)
ULK1 [mitochondrial outer membrane]
(R-HSA-8948145)
0.499
2
UniProt:Q9C0C7-3 AMBRA1
0.499
2
UniProt:P14778 IL1R1
1
IL1R1 [plasma membrane]
(R-HSA-197595)
0.499
2
UniProt:O14836 TNFRSF13B
1
TAC1 [plasma membrane]
(R-HSA-5668752)
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text