Reactome | HPSE(36-109) [lysosomal lumen]

HPSE(36-109) [lysosomal lumen]

Stable Identifier

R-HSA-1667006

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

HPSE, HPSE 8kDa, Heparanase, HPSE_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y251 HPSE

Gene Names

HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1

Chain

signal peptide:1-35, chain:36-109, propeptide:110-157, chain:158-543

Reference Genes

BioGPS Gene:10855 HPSE

COSMIC (genes):HPSE HPSE

CTD Gene:10855 HPSE

dbSNP Gene:10855 HPSE

ENSEMBL:ENSG00000173083 HPSE

HGNC:5164 HPSE

KEGG Gene (Homo sapiens):10855 HPSE

Monarch:10855 HPSE

NCBI Gene:10855 HPSE

OMIM:604724 HPSE

UCSC:Q9Y251 HPSE

Reference Transcript

Other Identifiers

0000130524

10855

11722662_a_at

11758873_a_at

16977537

219403_s_at

222881_at

2775995

2775996

2775997

2775998

2775999

2776000

2776001

2776002

2776003

2776004

2776005

2776008

2776009

2776015

2776016

2776018

2776019

2776020

2776021

2776022

2776023

45598_at

8101449

A_21_P0000064

A_23_P256107

A_24_P345866

GE80403

GO:0002376

GO:0003674

GO:0004566

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0006027

GO:0006029

GO:0006810

GO:0006950

GO:0007155

GO:0007160

GO:0007165

GO:0008150

GO:0008283

GO:0009056

GO:0010575

GO:0016020

GO:0016192

GO:0016787

GO:0016798

GO:0030194

GO:0030200

GO:0030305

GO:0031012

GO:0031410

GO:0033690

GO:0035580

GO:0042060

GO:0043202

GO:0043226

GO:0043231

GO:0043312

GO:0045121

GO:0045545

GO:0048646

GO:0048856

GO:0051797

GO:0051798

GO:0051897

GO:0060055

GO:0061042

HMNXSV003019122

HMNXSV003044719

ILMN_1779547

ILMN_2092850

PH_hs_0003210

TC04001347.hg

TC04002616.hg

g5729872_3p_a_at

g5880862_3p_at

Participates

as a component of

HPSE dimer [lysosomal lumen] (Homo sapiens)

Other forms of this molecule

HPSE(36-109) [extracellular region]

HPSE(158-543) [extracellular region]

HPSE(36-109) [specific granule lumen]

HPSE(158-543) [specific granule lumen]

HPSE(158-543) [lysosomal lumen]

Inferred To

Dmel\CG14309 [lysosomal lumen] (Drosophila melanogaster)

Hpse [lysosomal lumen] (Mus musculus)

Hpse [lysosomal lumen] (Rattus norvegicus)

hpse [lysosomal lumen] (Danio rerio)

HPSE [lysosomal lumen] (Canis familiaris)

HPSE [lysosomal lumen] (Gallus gallus)

HPSE [lysosomal lumen] (Sus scrofa)

Cross References

RefSeq

NP_001092010.1, NP_001186759.1, NP_001159970.1, NP_006656.2

Guide to Pharmacology - Targets

2996

OpenTargets

ENSG00000173083

ZINC - Substances

HPSE_HUMAN

ZINC target

Q9Y251

PRO

Q9Y251

GlyGen

Q9Y251

PDB

5LA4, 5E97, 5E9B, 5LA7, 5E8M, 5E98, 5E9C, 5L9Y, 6ZDM, 5L9Z

HPA

ENSG00000173083-HPSE

GeneCards

Q9Y251

Ensembl

ENSP00000384262, ENST00000311412, ENST00000513463, ENST00000512196, ENSP00000421365, ENST00000509906, ENST00000405413, ENSP00000421038, ENSP00000308107, ENSP00000423265, ENSG00000173083

Pharos - Targets

Q9Y251

ZINC - Predictions - Purchasable

HPSE_HUMAN

HMDB Protein

HMDBP02807