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About
What is Reactome ?
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Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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NGF [extracellular region]
Stable Identifier
R-HSA-167034
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Nerve Growth Factor, Neurotrophin
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NADE modulates death signalling (Homo sapiens)
14-3-3epsilon attentuates NADE-related apoptosis (Homo sapiens)
NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] (Homo sapiens)
NGF:p75NTR:NADE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NGF:p75NTR:NADE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
p75NTR binds to NADE (Homo sapiens)
NGF:p75NTR:NADE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)
NGF:p75NTR:NADE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
NGF:p75NTR complex binds to NRAGE (Homo sapiens)
NGF:p75NTR:NRAGE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NRAGE activates JNK (Homo sapiens)
NGF:p75NTR:NRAGE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NRAGE sequesters CHE1 in the cytoplasm (Homo sapiens)
NGF ligand:p75NTR:NRAGE:CHE1 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NGF:p75NTR:NRAGE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NRIF signals cell death from the nucleus (Homo sapiens)
NRIF and TRAF6 may activate JNK (Homo sapiens)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:NRIF [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NRIF binds to p75NTR (Homo sapiens)
NGF ligand:p75NTR:NRIF [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
TRAF6 binds to p75NTR:NRIF (Homo sapiens)
NGF ligand:p75NTR:NRIF [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:NRIF [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:NRIF [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Ceramide signalling (Homo sapiens)
Sphingomyelinase is activated by the NGF:p75NTR complex (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NFG and proNGF binds to p75NTR (Homo sapiens)
NGF homodimer binds to p75NTR (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
p75NTR negatively regulates cell cycle via SC1 (Homo sapiens)
PRDM4 (SC1) binds to p75NTR (Homo sapiens)
NGF:p75NTR:PRDM4 [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
p75NTR regulates axonogenesis (Homo sapiens)
Axonal growth stimulation (Homo sapiens)
NGF binding to p75NTR inactivates RHOA (Homo sapiens)
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
NF-kB is activated and signals survival (Homo sapiens)
IKKbeta is activated (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
IKK-beta is recruited (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
IRAK interacts with TRAF6 (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
IRAK is activated (Homo sapiens)
NGF ligand:p75NTR:IRAK1:MYD88 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
MYD88 dissociates (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
TRAF6 is auto-ubiquitinated (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
p62 is recruited and forms a complex with TRAF6 (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
p62 recruits an atypical PKC (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
p75NTR interacts with IRAK:MYD88 (Homo sapiens)
NGF ligand:p75NTR:IRAK1:MYD88 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
p75NTR interacts with RIP2 (Homo sapiens)
NGF:p75NTR:RIP2 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Expression and Processing of Neurotrophins (Homo sapiens)
NGF processing (Homo sapiens)
Pro-beta-NGF and mature beta-NGF are secreted (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Activation of TRKA receptors (Homo sapiens)
TRKA activation by NGF (Homo sapiens)
Activated TrkA receptor internalizes to endosomes (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
The bound receptor dimerizes (Homo sapiens)
beta-NGF dimer:TrkA receptor [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
beta-NGF dimer:TrkA receptor dimer [plasma membrane] (Homo sapiens)
beta-NGF dimer:TrkA receptor [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
TrkA receptor autophosphorylates (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
beta-NGF dimer:TrkA receptor dimer [plasma membrane] (Homo sapiens)
beta-NGF dimer:TrkA receptor [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
beta-NGF dimer binds to TrkA receptor (Homo sapiens)
beta-NGF dimer:TrkA receptor [plasma membrane] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
PI3K/AKT activation (Homo sapiens)
Active IRS recruits PI3K to the plasma membrane and activates it (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Active TRKA binds IRS1/2 (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Activated TrkA receptor:IRS1/2 [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
TRKA phosphorylates IRS (Homo sapiens)
Activated TrkA receptor:IRS1/2 [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
PLC-gamma1 signalling (Homo sapiens)
Active PLCG1 dissociates from TrkA receptor (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Active TrkA receptor:Phospho-PLCG1 complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Binding of PLCG1 to active TrkA receptor (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Active TrkA receptor:PLCG1 complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
TrkA phosphorylates PLCG1 (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Active TrkA receptor:PLCG1 complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Active TrkA receptor:Phospho-PLCG1 complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Retrograde neurotrophin signalling (Homo sapiens)
Axonal transport of NGF:Trk complexes (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle:dynein:dynactin complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Formation of clathrin-coated vesicle (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
ARMS-mediated activation (Homo sapiens)
ARMS is phosphorylated by active TrkA receptor (Homo sapiens)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
ARMS:Crk complex binds to active TrkA receptor (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
BRAF in Rap1-GTP complex:BRAF complex autophosphorylates (Homo sapiens)
Rap1-GTP complex:BRAF complex [plasma membrane] (Homo sapiens)
Active TrkA receptor:Phospho-ARMS:Crk:C3G complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Rap1-GTP complex:p-S,T-BRAF complex [plasma membrane] (Homo sapiens)
Active TrkA receptor:Phospho-ARMS:Crk:C3G complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)
Active TrkA receptor:Phospho-ARMS:Crk:C3G complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Crk's SH3 domain engages C3G (Homo sapiens)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Active TrkA receptor:Phospho-ARMS:Crk:C3G complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Rap1-GTP complex binds BRAF complex (Homo sapiens)
Rap1-GTP complex [plasma membrane] (Homo sapiens)
Active TrkA receptor:Phospho-ARMS:Crk:C3G complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Rap1-GTP complex:BRAF complex [plasma membrane] (Homo sapiens)
Active TrkA receptor:Phospho-ARMS:Crk:C3G complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Signalling to RAS (Homo sapiens)
Phospho-Shc dissociates from the TrkA receptor (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Activated TrkA receptor:p-SHC [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
SHC binds to the activated TrkA receptor (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Activated TrkA receptor:SHC [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
SHC, complexed with TrkA, is tyrosine-phosphorylated (Homo sapiens)
Activated TrkA receptor:SHC [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Activated TrkA receptor:p-SHC [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Signalling to p38 via RIT and RIN (Homo sapiens)
RIT/RIN are activated (Homo sapiens)
Active Trk receptor complex:RIT/RIN-GTP [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Active TrkA receptor complex:RIT/RIN-GDP [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
RIT/RIN-GTP binds B-RAF (Homo sapiens)
Active Trk receptor complex:RIT/RIN-GTP [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Active Trk receptor complex:RIT/RIN-GTP:B-RAF [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
TRKA recruits RIT and RIN (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Active TrkA receptor complex:RIT/RIN-GDP [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
Signalling to STAT3 (Homo sapiens)
STAT3 activation (Homo sapiens)
Activated TrkA receptor complex [plasma membrane] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01138 NGF
Gene Names
NGF, NGFB
Chain
signal peptide:1-18, propeptide:19-121, chain:122-241
Reference Genes
BioGPS Gene:4803 NGF
COSMIC (genes):NGF NGF
CTD Gene:4803 NGF
dbSNP Gene:4803 NGF
ENSEMBL:ENSG00000134259 NGF
HGNC:7808 NGF
KEGG:hsa:4803 NGF
Monarch:4803 NGF
NCBI Gene:4803 NGF
OMIM:162030 NGF
UCSC:P01138 NGF
Reference Transcript
RefSeq:XM_006710663.3 NGF
RefSeq:NM_002506.2 NGF
Participates
as a component of
mature beta-NGF homodimer [extracellular region] (Homo sapiens)
beta-NGF homodimer [extracellular region] (Homo sapiens)
Other forms of this molecule
NGF(19-241) [endoplasmic reticulum lumen]
NGF(19-241) [Golgi lumen]
NGF(1-241) [endoplasmic reticulum lumen]
NGF [cytosol]
NGF [Golgi lumen]
NGF(19-241) [extracellular region]
Inferred To
Ghost homologue of NGF [extracellular region]
(Caenorhabditis elegans)
Ghost homologue of NGF [extracellular region]
(Dictyostelium discoideum)
Ghost homologue of NGF [extracellular region]
(Drosophila melanogaster)
Ghost homologue of NGF [extracellular region]
(Schizosaccharomyces pombe)
NGF [extracellular region]
(Bos taurus)
NGF [extracellular region]
(Canis familiaris)
NGF [extracellular region]
(Gallus gallus)
NGF [extracellular region]
(Sus scrofa)
beta-NGF [extracellular region]
(Mus musculus)
beta-NGF [extracellular region]
(Rattus norvegicus)
ngf [extracellular region]
(Danio rerio)
ngf [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
XP_006710726.1
,
NP_002497.2
OpenTargets
ENSG00000134259
ENSEMBL
ENSP00000502380
,
ENST00000680540
,
ENSP00000505694
,
ENSG00000134259
,
ENST00000675637
,
ENST00000676038
,
ENST00000679806
,
ENST00000680116
,
ENSP00000506492
,
ENSP00000358525
,
ENST00000680752
,
ENSP00000502831
,
ENSP00000505558
,
ENST00000369512
,
ENSP00000506569
ZINC - Substances
NGF_HUMAN
ZINC target
P01138
PRO
P01138
GlyGen
P01138
PDB
1SG1
,
1WWW
,
5JZ7
,
4ZBN
,
2IFG
,
4EDW
,
6YW8
,
4EDX
HPA
ENSG00000134259-NGF
GeneCards
NGF
Pharos - Targets
P01138
Orphanet
NGF
HMDB Protein
HMDBP02581
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07174 Ngfr
8
Ngfr [nucleoplasm]
(R-RNO-197473)
Ngfr [extracellular region]
(R-RNO-194470)
Ngfr [endosome]
(R-RNO-209541)
Ngfr [plasma membrane]
(R-RNO-194509)
Ngfr [cytosol]
(R-RNO-194458)
Ngfr [plasma membrane]
(R-RNO-194476)
Tumor necrosis factor receptor superfamily member 16 [plasma membrane]
(R-RNO-193863)
Ngfr [plasma membrane]
(R-RNO-193664)
0.722
3
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
NTRK1 [plasma membrane]
(R-HSA-3008784)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
0.683
3
UniProt:Q99523 SORT1
2
SORT1 [cytoplasmic vesicle membrane]
(R-HSA-434221)
SORT1 [Golgi membrane]
(R-HSA-434332)
0.676
5
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
9
UniProt:P20042 EIF2S2
1
EIF2S2 [cytosol]
(R-HSA-72512)
0.556
3
UniProt:P08138 NGFR
7
NGFR [plasma membrane]
(R-HSA-193664)
NGFR(251-427) [plasma membrane]
(R-HSA-194476)
NGFR(273-427) [cytosol]
(R-HSA-194458)
NGFR(251-272) [plasma membrane]
(R-HSA-194509)
NGFR(251-427) [endosome]
(R-HSA-209541)
NGFR(29-250) [extracellular region]
(R-HSA-194470)
NGFR(273-427) [nucleoplasm]
(R-HSA-197473)
0.544
2
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