HIV Transcription Elongation

Stable Identifier
R-HSA-167169
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HIV Transcription Elongation
Click the image above or here to open this pathway in the Pathway Browser
In the absence of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al., 1987). While initiation of transcription from the HIV-1 LTR and formation of the early elongation complex occurs normally, transcription elongation is incomplete with non-processive polymerases disengaging from the proviral DNA template prematurely (reviewed in Karn 1999). The mechanism of Tat-mediated elongation is described below.
Literature References
PubMed ID Title Journal Year
10550206 Tackling Tat

Karn, J

J Mol Biol 1999
15049426 Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages

Herrmann, CH, Rice, AP

Curr HIV Res 2003
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
transcription elongation by RNA polymerase II (0006368)
Inferred From
RNA Polymerase II Transcription Elongation (Homo sapiens)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Matthews, L  (2005-07-27)
Rice, AP  (2005-07-27)
Created
Matthews, L  (2005-10-11)
Cite Us!