Reactome | Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex

Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex

Stable Identifier

R-HSA-167191

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Late Phase of HIV Life Cycle (Homo sapiens)
        
        Transcription of the HIV genome (Homo sapiens)
        
        HIV Transcription Elongation (Homo sapiens)
        
        Tat-mediated elongation of the HIV-1 transcript (Homo sapiens)
        
        Formation of HIV-1 elongation complex containing HIV-1 Tat (Homo sapiens)
        
        Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)

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Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex

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The association between Tat, TAR and P-TEFb is believed to bring the catalytic subunit of P-TEFb(Cyclin T1:Cdk9) in close proximity to Pol II where it hyperphosphorylates the CTD of Pol II (Herrmann et al., 1995; Zhou et al. 2000). In the presence of Tat, P-TEFb(Cyclin T1:CDK9) has been shown to phosphorylate serine 5 in addition to serine 2 suggesting that modification of the substrate specificity of CDK9 may play a role in the ability of Tat to promote transcriptional elongation (Zhou et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10866664	Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription Kashanchi, F, Brady, JN, Halanski, MA, Radonovich, MF, Price, DH, Zhou, M, Peng, J	Mol Cell Biol	2000
7853496	Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor Rice, AP, Herrmann, CH	J Virol	1995

Participants

Input

Output

Participates

as an event of

Formation of HIV-1 elongation complex containing HIV-1 Tat (Homo sapiens)

Catalyst Activity

RNA polymerase II CTD heptapeptide repeat kinase activity of Tat:P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm]

Physical Entity

Tat:P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Homo sapiens)

Activity

RNA polymerase II CTD heptapeptide repeat kinase activity (GO:0008353)

Inferred From

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)

Disease

Name	Identifier	Synonyms
Human immunodeficiency virus infectious disease	DOID:526	HIV infection

Authored

Matthews, L (2005-07-27)

Rice, AP (2005-07-27)

Created

Matthews, L (2005-10-12)