7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest

Stable Identifier
R-HSA-167284
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
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RNA Pol II arrest is believed to be a result of irreversible backsliding of the enzyme by ~7-14 nucleotides. It is suggested that, arrest leads to extrusion of displaced transcripts 3'-end through the small pore near the Mg2+ ion. Pol II arrest may lead to abortive termination of elongation due to irreversible trapping of the 3'-end of the displaced transcript in the pore (reviewed by Shilatifard et al., 2003).
Literature References
PubMed ID Title Journal Year
12676794 The RNA polymerase II elongation complex.

Conaway, JW, Shilatifard, A, Conaway, RC

Annu Rev Biochem 2003
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7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Matthews, L  (2005-07-27)
Rice, AP  (2005-07-27)
Created
Matthews, L  (2005-10-14)
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