Reactome | G-protein alpha subunit is inactivated

G-protein alpha subunit is inactivated

Stable Identifier

R-HSA-167415

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytoplasmic side of plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein activation (Homo sapiens)
        
        G-protein alpha subunit is inactivated (Homo sapiens)

General

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Slow intrisinc GTPase activity results in an inactivation of the alpha-i subunit by hydrolyzing GTP to GDP.

Literature References

PubMed ID	Title	Journal	Year
7937899	Mechanism of GTP hydrolysis by G-protein alpha subunits Kleuss, C, Gilman, AG, Sprang, SR, Raw, AS, Lee, E	Proc Natl Acad Sci U S A	1994
8073283	Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis Berghuis, AM, Linder, ME, Gilman, AG, Sprang, SR, Coleman, DE, Lee, E	Science	1994