Reactome | GNAZ [plasma membrane]

GNAZ [plasma membrane]

Stable Identifier

R-HSA-167416

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G protein alpha (z), G(z)

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G-protein alpha (z):GTP [plasma membrane] (Homo sapiens)
        
        GNAZ [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19086 GNAZ

Gene Names

GNAZ

Chain

initiator methionine:, chain:2-355

Reference Genes

BioGPS Gene:2781 GNAZ

COSMIC (genes):GNAZ GNAZ

CTD Gene:2781 GNAZ

dbSNP Gene:2781 GNAZ

ENSEMBL:ENSG00000128266 GNAZ

HGNC:4395 GNAZ

KEGG:hsa:2781 GNAZ

Monarch:2781 GNAZ

NCBI Gene:2781 GNAZ

OMIM:139160 GNAZ

UCSC:P19086 GNAZ

Reference Transcript

RefSeq:NM_002073.3 GNAZ

Other Identifiers

11723488_at

11749524_a_at

16927874

204993_PM_at

204993_at

2781

38279_at

3939126

3939132

3939133

3939134

3939135

3939136

3939137

3939145

3939146

3939147

3939148

3939149

8071671

A_23_P211363

A_23_P416581

A_33_P3282698

GE57445

GO:0001664

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005635

GO:0005737

GO:0005783

GO:0005834

GO:0005886

GO:0007165

GO:0007186

GO:0007188

GO:0007193

GO:0010855

GO:0016020

GO:0016787

GO:0019001

GO:0030425

GO:0031683

GO:0031821

GO:0043226

GO:0044297

GO:0045202

GO:0046676

GO:0046872

GO:0098664

GO:0098772

HMNXSV003002366

HMNXSV003025239

ILMN_1766182

J03260_s_at

PH_hs_0025573

TC22000126.hg

g4504050_3p_at

Participates

as a component of

Other forms of this molecule

p-S27-GNAZ [plasma membrane]

Inferred To

GNAI2 [plasma membrane] (Dictyostelium discoideum)

Ghost homologue of GNAZ [plasma membrane] (Drosophila melanogaster)

GNAZ [plasma membrane] (Bos taurus)

GNAZ [plasma membrane] (Caenorhabditis elegans)

GNAZ [plasma membrane] (Canis familiaris)

GNAZ [plasma membrane] (Gallus gallus)

GNAZ [plasma membrane] (Mus musculus)

GNAZ [plasma membrane] (Rattus norvegicus)

GNAZ [plasma membrane] (Saccharomyces cerevisiae)

GNAZ [plasma membrane] (Schizosaccharomyces pombe)

GNAZ [plasma membrane] (Sus scrofa)

GNAZ [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_002064.1

ENSEMBL

ENSG00000128266, ENST00000615612, ENSP00000478892

OpenTargets

ENSG00000128266

GeneCards

GNAZ

HPA

ENSG00000128266-GNAZ

PRO

P19086

Pharos - Targets

P19086

HMDB Protein

HMDBP11497

PDB

8DZS

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.527	2
UniProt:P54764 EPHA4	2	p-Y596,Y602-EPHA4 [plasma membrane] (R-HSA-3928352) EPHA4 [plasma membrane] (R-HSA-2682325)	0.527	2