Reactome | GNA11 [plasma membrane]

GNA11 [plasma membrane]

Stable Identifier

R-HSA-167446

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G protein alpha 11

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Signal amplification (Homo sapiens)
    - ADP signalling through P2Y purinoceptor 1 (Homo sapiens)
      - Activated P2Y purinoceptor 1 binds G-protein Gq (Homo sapiens)
        
        ADP:P2RY1:G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
      - Dissociation of the P2Y purinoceptor 1:Gq complex (Homo sapiens)
        
        ADP:P2RY1:G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
      - Gq activation by P2Y purinoceptor 1 (Homo sapiens)
        
        ADP:P2RY1:G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
        
        ADP:P2RY1:G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
      - P2Y purinoceptor 1 activates MAP kinase p38 alpha (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
    - Thromboxane signalling through TP receptor (Homo sapiens)
      - Activated TP receptor binds G-proten Gq (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
      - Dissociation of the TP:Gq complex (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
      - Gq activation by TP receptor (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
  - Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
    - Thrombin-activated PARs activate Gq (Homo sapiens)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
    - Thrombin-activated PARs binds G-protein Gq (Homo sapiens)
      - Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
    - Thrombin-activated PARs:Gq (active) dissociate (Homo sapiens)
      - G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
        
        GNA11 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29992 GNA11

Gene Names

GNA11, GA11

Chain

chain:1-359

Reference Genes

BioGPS Gene:2767 GNA11

COSMIC (genes):GNA11 GNA11

CTD Gene:2767 GNA11

dbSNP Gene:2767 GNA11

ENSEMBL:ENSG00000088256 GNA11

HGNC:4379 GNA11

KEGG:hsa:2767 GNA11

Monarch:2767 GNA11

NCBI Gene:2767 GNA11

OMIM:139313 GNA11

UCSC:P29992 GNA11

Reference Transcript

RefSeq:NM_002067.4 GNA11

Other Identifiers

11720663_a_at

11720664_at

16856887

204248_PM_at

204248_at

213766_PM_x_at

213766_x_at

213944_PM_x_at

213944_x_at

214679_PM_x_at

214679_x_at

2767

3053922

3053923

3053924

3816779

3816780

3816783

3816785

3816786

3816787

3816788

3816789

3816790

3816791

3816792

3816793

3816794

3816795

3816796

3816797

3816798

3816799

3816800

3816802

3816804

3816805

3816806

3816807

40562_3p_at

40562_PM_at

40562_at

41476_at

4920390_3p_s_at

55214_at

564_PM_at

564_at

57231_at

59679_at

8024557

8024566

89107_s_at

A_14_P105672

A_23_P142289

A_23_P5051

GE58050

GE88593

GO:0001501

GO:0001508

GO:0001664

GO:0001750

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005737

GO:0005765

GO:0005834

GO:0005886

GO:0007165

GO:0007186

GO:0007188

GO:0007200

GO:0007207

GO:0007213

GO:0007507

GO:0007603

GO:0008217

GO:0009649

GO:0016020

GO:0016787

GO:0019001

GO:0030234

GO:0031683

GO:0032024

GO:0043226

GO:0045202

GO:0045634

GO:0046872

GO:0048066

GO:0048856

GO:0060158

GO:0070062

GO:0071467

GO:0086100

GO:0098772

GO:0099105

GO:1904888

GO:1990806

HMNXSV003023578

Hs.323067.1.S1_3p_s_at

ILMN_1802397

ILMN_1903565

M69013_at

PH_hs_0025424

PH_hs_0036756

PH_hs_0040681

TC19000063.hg

TC19000064.hg

TC19001939.hg

g4504036_3p_s_at

Participates

as a member of

as a candidate of

G(q) alpha 11,14,15,Q [plasma membrane] (Homo sapiens)

Inferred To

Dmel\CG30054 [plasma membrane] (Drosophila melanogaster)

Guanine nucleotide-binding protein alpha-11 subunit [plasma membrane] (Bos taurus)

Homologues of GNA11 [plasma membrane] (Dictyostelium discoideum)

Homologues of GNA11 [plasma membrane] (Drosophila melanogaster)

egl-30 [plasma membrane] (Caenorhabditis elegans)

gna11b [plasma membrane] (Danio rerio)

BcDNA:SD21019 [plasma membrane] (Drosophila melanogaster)

GNA11 [plasma membrane] (Canis familiaris)

GNA11 [plasma membrane] (Dictyostelium discoideum)

GNA11 [plasma membrane] (Drosophila melanogaster)

GNA11 [plasma membrane] (Gallus gallus)

GNA11 [plasma membrane] (Mus musculus)

GNA11 [plasma membrane] (Rattus norvegicus)

GNA11 [plasma membrane] (Saccharomyces cerevisiae)

GNA11 [plasma membrane] (Schizosaccharomyces pombe)

GNA11 [plasma membrane] (Sus scrofa)

gbqA [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002058.2

ENSEMBL

ENST00000078429, ENSP00000078429

OpenTargets

ENSG00000088256

HPA

ENSG00000088256-GNA11

PRO

P29992

Pharos - Targets

P29992

GlyGen

P29992

Orphanet

GNA11

HMDB Protein

HMDBP02024

PDB

7RKF, 7TRY, 7XXH, 6OIJ

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	6

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