PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane

Stable Identifier
R-HSA-1675776
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane
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At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A), beta (PIP4K2B) and gamma (PIP4K2C) homodimers and heterodimers (Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015) phosphorylate phosphatidylinositol 5-phosphate (PI5P) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).

The following lists the above proteins with their corresponding literature references: PIP4K2A (Rameh et al. 1997, Clarke et al. 2008, Clarke and Irvine 2013), PIP4K2B (Rameh et al. 1997, Clarke and Irvine 2013) and PIP4K2C (Clarke and Irvine 2013, Clarke et al. 2015).
Literature References
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Catalyst Activity

1-phosphatidylinositol-5-phosphate 4-kinase activity of PIP4K2 dimers [cytosol]

Physical Entity
PIP4K2 dimers [cytosol] (Homo sapiens)
Activity
1-phosphatidylinositol-5-phosphate 4-kinase activity (GO:0016309)
Orthologous Events
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Rattus norvegicus)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Saccharomyces cerevisiae)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Schizosaccharomyces pombe)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Sus scrofa)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Xenopus tropicalis)
Cross References
Rhea
Authored
Williams, MG  (2011-10-18)
Reviewed
Porteu, F  (2016-02-08)
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
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