PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane

Stable Identifier
R-HSA-1675780
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
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At the plasma membrane, phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) (Balla et al. 2002, Minogue et al. 2001) and beta (PI4K2B) (Balla et al. 2002, Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P).

Literature References
PubMed ID Title Journal Year
11279162 Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family

Waugh, MG, Anderson, JS, Minogue, S, dos Santos, M, Cramer, R, Hsuan, JJ, Corless, S

J Biol Chem 2001
12324459 Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP

Wei, YJ, Barylko, B, Yamamoto, M, Albanesi, JP, Wlodarski, P, Sun, HQ, Martínez, M, Yin, HL, Kunii, K

J Biol Chem 2002
11923287 Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments

Balla, T, Tuymetova, G, Balla, A, Barshishat, M, Geiszt, M

J Biol Chem 2002
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Catalyst Activity

1-phosphatidylinositol 4-kinase activity of PI4K2A/2B [cytosol]

Physical Entity
PI4K2A/2B [cytosol] (Homo sapiens)
Activity
1-phosphatidylinositol 4-kinase activity (GO:0004430)
Orthologous Events
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Bos taurus)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Caenorhabditis elegans)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Canis familiaris)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Danio rerio)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Drosophila melanogaster)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Gallus gallus)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Mus musculus)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Rattus norvegicus)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Saccharomyces cerevisiae)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Schizosaccharomyces pombe)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Sus scrofa)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Xenopus tropicalis)
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
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