Reactome | PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane

PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane

Stable Identifier

R-HSA-1675795

Type

Reaction [transition]

Species

Homo sapiens

Compartment

late endosome membrane, cytosol

ReviewStatus

5/5

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PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane

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At the late endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2), myotubularin-related protein 4 (MTMR4), and myotubularin-related protein 7 (MTMR7) dephosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI).

The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008, Tsujita et al. 2004, Tronchere et al. 2004, Kim et al. 2002); MTMR2 (Cao et al. 2008, Kim et al. 2002); MTMR4 (Lorenzo et al. 2006); and MTMR7 (Mochizuki & Majerus 2003, Lorenzo et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
12890864	Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 Majerus, PW, Mochizuki, Y	Proc Natl Acad Sci U S A	2003
16787938	Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions Lorenzo, O, Clague, MJ, Urbé, S	J Cell Sci	2006
14722070	Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction Ijuin, T, Shisheva, A, Takenawa, T, Tsujita, K, Laporte, J, Yamamoto, A, Itoh, T	J Biol Chem	2004
14660569	Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells Payrastre, B, Pendaries, C, Pirola, L, Laporte, J, Tronchère, H, Mandel, JL, Chaussade, C, Liaubet, L	J Biol Chem	2004
18524850	Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking Bedrick, EJ, Wandinger-Ness, A, Cao, C, Laporte, J, Backer, JM	Mol Biol Cell	2008
17651088	Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes Wandinger-Ness, A, Cao, C, Laporte, J, Stein, MP, Backer, JM	Traffic	2007
11733541	Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease Taylor, GS, Torgersen, KM, Kim, SA, Dixon, JE	J Biol Chem	2002