PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane

Stable Identifier
R-HSA-1675810
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
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At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A) and beta (PIP5K1B) phosphorylate phosphatidylinositol (PI) to produce phosphatidylinositol 5-phosphate (PI5P) (Tolias et al. 1998).

Literature References
PubMed ID Title Journal Year
9660759 Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate

Rameh, LE, Cantley, LC, Ishihara, H, Shibasaki, Y, Prestwich, GD, Carpenter, CL, Chen, J, Tolias, KF

J Biol Chem 1998
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Output
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Catalyst Activity

1-phosphatidylinositol-5-kinase activity of PIP5K1A/B [cytosol]

Physical Entity
PIP5K1A/B [cytosol] (Homo sapiens)
Activity
1-phosphatidylinositol-5-kinase activity (GO:0052810)
Orthologous Events
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Bos taurus)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Canis familiaris)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Danio rerio)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Dictyostelium discoideum)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Drosophila melanogaster)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Gallus gallus)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Mus musculus)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Rattus norvegicus)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Saccharomyces cerevisiae)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Sus scrofa)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Xenopus tropicalis)
Cross References
Rhea
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
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