PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the Golgi membrane, phosphatidylinositol 4-phosphate (PI4P) inositol polyphosphate 5-phosphatase OCRL-1 (OCRL) (Choudhury et al. 2009, Suchy et al. 1995, Zhang et al. 1995) and 72 kDa inositol polyphosphate 5-phosphatase (INPP5E) (Bilas et al. 2009) dephosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to form phosphatidylinositol 4-phosphate (PI4P). INPP5E is located in the Golgi membrane, mediated by its N-terminal proline-rich domain (Kong et al. 2000).

Literature References
PubMed ID Title Journal Year
10764818 The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase

Kisseleva, MV, Wilson, MP, Majerus, PW

J Biol Chem 2000
19211563 Differential clathrin binding and subcellular localization of OCRL1 splice isoforms

Choudhury, R, Noakes, CJ, McKenzie, E, Kox, C, Lowe, M

J Biol Chem 2009
10806194 Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network

Kong, AM, Speed, CJ, O'Malley, CJ, Layton, MJ, Meehan, T, Loveland, KL, Cheema, S, Ooms, LM, Mitchell, CA

J Biol Chem 2000
8634694 Lowe syndrome, a deficiency of phosphatidylinositol 4,5-bisphosphate 5-phosphatase in the Golgi apparatus

Suchy, SF, Olivos-Glander, IM, Nussabaum, RL

Hum Mol Genet 1995
7761412 The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase

Zhang, X, Jefferson, AB, Auethavekiat, V, Majerus, PW

Proc Natl Acad Sci U S A 1995
19668216 Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

Bielas, SL, Silhavy, JL, Brancati, F, Kisseleva, MV, Al-Gazali, L, Sztriha, L, Bayoumi, RA, Zaki, MS, Abdel-Aleem, A, Rosti, RO, Kayserili, H, Swistun, D, Scott, LC, Bertini, E, Boltshauser, E, Fazzi, E, Travaglini, L, Field, SJ, Gayral, S, Jacoby, M, Schurmans, S, Dallapiccola, B, Majerus, PW, Valente, EM, Gleeson, JG

Nat Genet 2009
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity of OCRL/INPP5E [cytosol]

Orthologous Events
Cite Us!