Reactome | PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane

PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane

Stable Identifier

R-HSA-1675836

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the plasma membrane, synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 aka synaptojanin-1 (SYNJ1) (Guo et al. 1999, Mani et al. 2007) and -2 (SYNJ2) (Malecz et al. 2000) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P).

Literature References

PubMed ID	Title	Journal	Year
18093523	The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals Ryan, TA, Cremona, O, Di Paolo, G, Mani, M, Lucast, L, De Camilli, P, Lee, SY	Neuron	2007
11084340	Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis Qiu, R, McCabe, PC, Malecz, N, Spaargaren, C, Chuang, Y, Symons, M	Curr Biol	2000
10224048	SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases Lemrow, SM, Guo, S, Stolz, LE, York, JD	J Biol Chem	1999