PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane

Stable Identifier
R-HSA-1675836
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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At the plasma membrane, synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 aka synaptojanin-1 (SYNJ1) (Guo et al. 1999, Mani et al. 2007) and -2 (SYNJ2) (Malecz et al. 2000) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P).
Literature References
PubMed ID Title Journal Year
18093523 The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals

Ryan, TA, Cremona, O, Di Paolo, G, Mani, M, Lucast, L, De Camilli, P, Lee, SY

Neuron 2007
11084340 Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis

Qiu, R, McCabe, PC, Malecz, N, Spaargaren, C, Chuang, Y, Symons, M

Curr Biol 2000
10224048 SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases

Lemrow, SM, Guo, S, Stolz, LE, York, JD

J Biol Chem 1999
Participants
Participates
Catalyst Activity

phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity of SYNJs,OCRL [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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