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AP2M1 [plasma membrane]
Stable Identifier
R-HSA-167585
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
AP-2 clathrin coat assembly protein, Clathrin -coated Pit Adapter Protein
Locations in the PathwayBrowser for interactor UniProt:O95782 AP2A1
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
Nef mediated downregulation of CD28 cell surface expression (Homo sapiens)
Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex (Homo sapiens)
AP2M1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96CW1 AP2M1
Gene Names
AP2M1, CLAPM1, KIAA0109
Chain
chain:1-435
Reference Genes
BioGPS Gene:1173 AP2M1
COSMIC (genes):AP2M1 AP2M1
CTD Gene:1173 AP2M1
dbSNP Gene:1173 AP2M1
ENSEMBL:ENSG00000161203 AP2M1
ENSEMBL_homo_sapiens_GENE:ENSG00000161203.14 AP2M1
HGNC:564 AP2M1
KEGG Gene (Homo sapiens):1173 AP2M1
Monarch:1173 AP2M1
NCBI Gene:1173 AP2M1
OMIM:601024 AP2M1
UCSC:Q96CW1 AP2M1
Reference Transcript
RefSeq:NM_001311198.1 AP2M1
RefSeq:NM_004068.3 AP2M1
RefSeq:NM_001025205.1 AP2M1
Other Identifiers
11724231_s_at
1173
11746645_x_at
11747195_x_at
11749846_x_at
16948738
200613_PM_at
200613_at
2655477
2655479
2655480
2655481
2655484
2655486
2655490
2655491
2655493
2655494
2655495
2655497
2655498
2655501
2655504
2655505
2655506
2655507
2655508
2655509
2655510
39795_at
8084345
A_33_P3378800
D63475_at
GE57272
GO:0002092
GO:0005048
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0005905
GO:0006886
GO:0006897
GO:0006900
GO:0008289
GO:0009898
GO:0015031
GO:0016020
GO:0016192
GO:0030122
GO:0030131
GO:0030666
GO:0030669
GO:0031410
GO:0031623
GO:0035615
GO:0036020
GO:0043226
GO:0044325
GO:0045202
GO:0045334
GO:0048488
GO:0050750
GO:0060090
GO:0061024
GO:0065003
GO:0070062
GO:0072583
GO:0072659
GO:0097494
GO:0097718
GO:0098794
GO:0098884
GO:0098894
GO:0098978
GO:1900244
GO:1903077
HMNXSV003025018
ILMN_1699598
ILMN_2402798
PH_hs_0025297
g4757993_3p_x_at
Participates
as a component of
CD28:Nef:Clathrin-coated Pit Adapter Protein Complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
planar gap junction plaques [plasma membrane] (Homo sapiens)
as an input of
Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex (Homo sapiens)
Other forms of this molecule
AP2M1 [lysosomal membrane]
AP2M1 [cytosol]
AP2M1 [clathrin-coated endocytic vesicle membrane]
AP2M1 [endolysosome membrane]
p-T156 AP2M1 [cytosol]
Inferred To
APM4 [plasma membrane]
(Saccharomyces cerevisiae)
AP2M1 [plasma membrane]
(Bos taurus)
AP2M1 [plasma membrane]
(Canis familiaris)
AP2M1 [plasma membrane]
(Danio rerio)
AP2M1 [plasma membrane]
(Drosophila melanogaster)
AP2M1 [plasma membrane]
(Gallus gallus)
AP2M1 [plasma membrane]
(Mus musculus)
AP2M1 [plasma membrane]
(Rattus norvegicus)
AP2M1 [plasma membrane]
(Sus scrofa)
AP2M1 [plasma membrane]
(Xenopus tropicalis)
apm4 [plasma membrane]
(Schizosaccharomyces pombe)
dpy-23 [plasma membrane]
(Caenorhabditis elegans)
Homologues of AP2M1 [plasma membrane]
(Danio rerio)
apm2 [plasma membrane]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001298127.1
,
NP_004059.2
,
NP_001020376.1
OpenTargets
ENSG00000161203
GeneCards
Q96CW1
HPA
ENSG00000161203-AP2M1
Ensembl
ENST00000439647
,
ENSP00000371894
,
ENSP00000481563
,
ENSP00000409081
,
ENSG00000161203
,
ENST00000382456
,
ENSP00000292807
,
ENST00000621863
,
ENST00000292807
PRO
Q96CW1
Pharos - Targets
Q96CW1
Orphanet
28614
PDB
1H6E
,
6BNT
,
6URI
Interactors (62)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z3C6 ATG9A
1
ATG9A [phagophore assembly site membrane]
(R-HSA-5671732)
0.895
22
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.828
8
UniProt:P63010 AP2B1
4
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [plasma membrane]
(R-HSA-167690)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
0.809
7
UniProt:Q15311 RALBP1
1
RALBP1 [cytosol]
(R-HSA-195194)
0.76
7
UniProt:Q92609 TBCD5
0.737
4
UniProt:Q2M2I8 AAK1
1
AAK1 [cytosol]
(R-HSA-8854795)
0.725
6
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.725
7
UniProt:Q9UHP6 RSP14
0.666
6
UniProt:Q68CQ4 UTP25
1
DIEXF [nucleoplasm]
(R-HSA-6790689)
0.666
7
UniProt:P51116 FXR2
0.653
3
UniProt:O94973 AP2A2
6
AP2A2(1-939) [endolysosome membrane]
(R-HSA-6784819)
AP2A2(1-939) [ficolin-1-rich granule membrane]
(R-HSA-6800414)
AP2A2(1-939) [secretory granule membrane]
(R-HSA-6800412)
AP2A2(1-939) [plasma membrane]
(R-HSA-177502)
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138448)
AP2A2(1-939) [cytosol]
(R-HSA-182155)
0.643
5
UniProt:Q9NVZ3 NECAP2
1
NECAP2 [cytosol]
(R-HSA-8863466)
0.643
5
UniProt:Q8NC96 NECAP1
3
NECAP1 [cytosol]
(R-HSA-8863464)
NECAP1 [Golgi membrane]
(R-HSA-434327)
NECAP1 [cytoplasmic vesicle membrane]
(R-HSA-434218)
0.643
3
UniProt:P53680 AP2S1
4
AP2S1 [cytosol]
(R-HSA-182197)
AP2S1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130707)
AP2S1 [plasma membrane]
(R-HSA-389382)
AP2S1 [endolysosome membrane]
(R-HSA-6784821)
0.643
5
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.643
5
UniProt:O15084 ANKRD28
2
ANKRD28 [cytosol]
(R-HSA-5685714)
ANKRD28 [nucleoplasm]
(R-HSA-9686571)
0.643
3
UniProt:P49757 NUMB
1
NUMB [plasma membrane]
(R-HSA-443595)
0.643
6
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.643
5
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
9
UniProt:Q99633 PRPF18
1
PRPF18 [nucleoplasm]
(R-HSA-5688093)
0.556
3
UniProt:Q9NZ81 PRR13
0.556
3
UniProt:Q9P0T4 ZN581
0.556
3
UniProt:Q86YD7 F90A1
0.556
5
UniProt:Q1ED39 KNOP1
0.556
3
UniProt:Q99880 H2BC13
9
Ub-HIST1H2BL [nucleoplasm]
(R-HSA-6782543)
AcK-HIST1H2BL [nucleoplasm]
(R-HSA-4549254)
HIST1H2BL [extracellular region]
(R-HSA-977579)
AcK13-HIST1H2BL [nucleoplasm]
(R-HSA-4568650)
AcK16-HIST1H2BL [nucleoplasm]
(R-HSA-4568697)
AcK6-HIST1H2BL [nucleoplasm]
(R-HSA-4568719)
AcK21-HIST1H2BL [nucleoplasm]
(R-HSA-4568674)
Ub-121-HIST1H2BL [nucleoplasm]
(R-HSA-3364013)
HIST1H2BL [nucleoplasm]
(R-HSA-181920)
0.556
3
UniProt:Q9BU76 MMTAG2
3
MMTAG2 [secretory granule lumen]
(R-HSA-6801073)
MMTAG2 [extracellular region]
(R-HSA-6806452)
MMTAG2 [ficolin-1-rich granule lumen]
(R-HSA-6801074)
0.556
3
UniProt:Q03393 PTS
2
PTS [cytosol]
(R-HSA-1475061)
p-S19-PTS [cytosol]
(R-HSA-1475426)
0.556
3
UniProt:Q16778 H2BC21
9
Ub-HIST2H2BE [nucleoplasm]
(R-HSA-6782539)
Ack-HIST2H2BE [nucleoplasm]
(R-HSA-4549257)
HIST2H2BE [extracellular region]
(R-HSA-977571)
AcK13-HIST2H2BE [nucleoplasm]
(R-HSA-4568651)
AcK21-HIST2H2BE [nucleoplasm]
(R-HSA-4568716)
AcK6-HIST2H2BE [nucleoplasm]
(R-HSA-4568679)
AcK16-HIST2H2BE [nucleoplasm]
(R-HSA-4568660)
Ub-121-HIST2H2BE [nucleoplasm]
(R-HSA-3364018)
HIST2H2BE [nucleoplasm]
(R-HSA-181908)
0.556
3
UniProt:Q96MH2 HEXI2
0.556
3
UniProt:P35268 RPL22
1
RPL22 [cytosol]
(R-HSA-72428)
0.556
3
UniProt:Q9BSU3 NAA11
0.556
3
UniProt:Q8N3F0 MTURN
0.556
3
UniProt:Q8NAV1 PRPF38A
1
PRPF38A [nucleoplasm]
(R-HSA-8867897)
0.556
5
UniProt:Q6ZUT1 NKAP1
0.556
3
UniProt:Q8N9N8 EIF1A
0.556
3
IntAct:EBI-16429620 CCSB ORF ID
0.556
3
UniProt:Q96EY4 TMA16
0.556
3
UniProt:Q8N8X9 MB213
0.556
5
UniProt:P62807 H2BC4
9
Ub-HIST1H2BC [nucleoplasm]
(R-HSA-6782552)
AcK-HIST1H2BC [nucleoplasm]
(R-HSA-4549246)
HIST1H2BC [extracellular region]
(R-HSA-977564)
AcK16-HIST1H2BC [nucleoplasm]
(R-HSA-4568634)
AcK6-HIST1H2BC [nucleoplasm]
(R-HSA-4568623)
AcK13-HIST1H2BC [nucleoplasm]
(R-HSA-4568620)
AcK21-HIST1H2BC [nucleoplasm]
(R-HSA-4568626)
Ub-121-HIST1H2BC [nucleoplasm]
(R-HSA-3364029)
HIST1H2BC [nucleoplasm]
(R-HSA-181906)
0.556
5
UniProt:P55081 MFAP1
1
MFAP1 [nucleoplasm]
(R-HSA-2396419)
0.556
3
UniProt:Q00013 MPP1
1
MPP1 [plasma membrane]
(R-HSA-420423)
0.556
5
UniProt:P0DPH9 CX05B
0.556
3
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.556
5
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.553
2
UniProt:Q59EK9 RUN3A
0.547
3
UniProt:Q77IS8 NCAP
0.544
2
UniProt:P27958-PRO_0000037566
0.543
4
UniProt:P57739 CLDN2
2
CLDN2 [plasma membrane]
(R-HSA-419994)
CLDN2 [cell junction]
(R-HSA-421235)
0.537
4
UniProt:P11274 BCR
4
BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838979)
p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1839041)
BCR(1-584)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1604524)
BCR [cytosol]
(R-HSA-195200)
0.527
3
UniProt:O95782 AP2A1
5
AP2A1 [endolysosome membrane]
(R-HSA-6784829)
AP2A1 [endocytic vesicle membrane]
(R-HSA-416641)
AP2A1 [plasma membrane]
(R-HSA-177494)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138449)
AP2A1 [cytosol]
(R-HSA-182143)
0.527
4
UniProt:P0DTD1-PRO_0000449628 REP
0.527
2
UniProt:Q0JRZ9 FCHO2
1
FCHO2 [cytosol]
(R-HSA-8862260)
0.527
3
UniProt:Q10567 AP1B1
5
AP1B1 [cytoplasmic vesicle membrane]
(R-HSA-351181)
AP1B1 [Golgi membrane]
(R-HSA-350809)
AP1B1 [lysosomal membrane]
(R-HSA-432699)
AP1B1 [trans-Golgi network membrane]
(R-HSA-2130596)
AP1B1 [cytosol]
(R-HSA-167705)
0.527
4
UniProt:Q16626 MEA1
0.527
4
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
0.527
2
UniProt:Q96D71 REPS1
1
REPS1 [cytosol]
(R-HSA-8862265)
0.527
4
UniProt:Q9UBC2 EPS15L1
2
EPS15L1 [plasma membrane]
(R-HSA-182937)
EPS15L1 [cytosol]
(R-HSA-8935900)
0.527
4
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P18272 NCAP
0.524
2
UniProt:Q01968 OCRL
4
OCRL [Golgi membrane]
(R-HSA-434339)
OCRL [cytoplasmic vesicle membrane]
(R-HSA-434214)
OCRL [plasma membrane]
(R-HSA-3769049)
OCRL [cytosol]
(R-HSA-1806196)
0.508
3
UniProt:P51114 FXR1
2
FXR1(2-784)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802326)
FXR1(2-784)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802530)
0.508
2
UniProt:A9UF07 A9UF07
0.462
2
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