PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane

Stable Identifier
R-HSA-1675866
Type
Reaction [transition]
Species
Homo sapiens
Compartment
late endosome membrane, cytosol
ReviewStatus
5/5
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PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
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At the late endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The PIKFYVE kinase component phosphorylates phosphatidylinositol (PI) to phosphatidylinositol 5-phosphate (PI5P) (Sbrissa et al. 1999, Sbrissa et al. 2002). The PAS complex is present in the cytosol and is recruited to the membrane.
Literature References
PubMed ID Title Journal Year
10419465 PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin

Sbrissa, D, Shisheva, A, Ikonomov, OC

J Biol Chem 1999
12270933 Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells

Sbrissa, D, Shisheva, A, Deeb, R, Ikonomov, OC

J Biol Chem 2002
Participants
Input
Output
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as an event of
Catalyst Activity

1-phosphatidylinositol-5-kinase activity of PIKFYVE:VAC14:FIG4 [late endosome membrane]

Physical Entity
PIKFYVE:VAC14:FIG4 [late endosome membrane] (Homo sapiens)
Activity
1-phosphatidylinositol-5-kinase activity (GO:0052810)
Inferred From
PI is phosphorylated to PI5P by Pikfyve at the late endosome membrane (Mus musculus)
Cross References
Rhea
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
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