PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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At the Golgi membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 is bound to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). This PIK3C3:PIK2R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P).

The following lists the above proteins with their corresponding literature references: PIK3C3:PIK2R4 (Panaretou et al. 1997, Volinia et al. 1995) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).
Literature References
PubMed ID Title Journal Year
7628435 A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

Waterfield, MD, Dhand, R, Stein, R, MacDougall, LK, Vanhaesebroeck, B, Volinia, S, Zvelebil, MJ, Domin, J, Panaretou, C

EMBO J 1995
10805725 Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

Waterfield, MD, Arcaro, A, Wallasch, C, Ullrich, A, Zvelebil, MJ, Domin, J

Mol Cell Biol 2000
8999962 Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex

Waterfield, MD, Domin, J, Panaretou, C, Cockcroft, S

J Biol Chem 1997
10766823 The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles

Waterfield, MD, Gaidarov, I, Domin, J, Smith, ME, Keen, JH

J Biol Chem 2000
Catalyst Activity

1-phosphatidylinositol-3-kinase activity of PIK3C2A/3 [cytosol]

Orthologous Events
Cross References
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