Reactome | Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome

Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome

Stable Identifier

R-HSA-1676041

Type

Reaction [transition]

Species

Homo sapiens

Compartment

early endosome membrane, late endosome membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The presence of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) in the early endosome membrane stimulates the vesicle maturation into the late endosome (Cabezas et al. 2006, Ikonomov et al. 2006, Ikonomov et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11285266	Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve Sbrissa, D, Shisheva, A, Ikonomov, OC	J Biol Chem	2001
16510848	Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion Sbrissa, D, Shisheva, A, Ikonomov, OC	Am J Physiol Cell Physiol	2006
16448788	Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1 Stenmark, H, Cabezas, A, Pattni, K	Gene	2006