Reactome | PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane

PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane

Stable Identifier

R-HSA-1676082

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane

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At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 4-phosphate (PI4P) to produce phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).

The following lists the above proteins with their corresponding literature references: PIP5K1A (Halstead et al. 2006, Zhang et al. 1997), PIP5K1B (Zhang et al. 1997), and PIP5K1C (Di Paolo et al. 2002).

This reaction is of particular interest because its regulation by small GTPases of the RHO and ARF families, not yet annotated here, ties the process of phosphatidylinositol phosphate biosynthesis to regulation of the actin cytoskeleton and vesicular trafficking, and hence to diverse aspects of cell motility and signalling (Oude Weernink et al. 2004, 2007).

Literature References

PubMed ID	Title	Journal	Year
15464023	Regulation and cellular roles of phosphoinositide 5-kinases Schmidt, M, Jakobs, KH, Oude Weernink, PA	Eur J Pharmacol	2004
17245604	Phospholipase D signaling: orchestration by PIP2 and small GTPases Schmidt, M, Oude Weernink, PA, López de Jesús, M	Naunyn Schmiedebergs Arch Pharmacol	2007
9211928	Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules Thum, O, Majerus, PW, Parker, GJ, Boronenkov, IV, Zhang, X, Prestwich, GD, Anderson, RA, Loijens, JC, Chen, J, Norris, FA	J Biol Chem	1997
12422219	Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin Cestra, G, Pellegrini, L, Di Paolo, G, Zoncu, R, Letinic, K, Wenk, MR, Voronov, S, De Camilli, P, Guo, J, Chang, S	Nature	2002
16979564	A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis Jalink, K, Heck, AJ, Mohammed, S, Halstead, JR, Meeuws, S, Divecha, N, D'Santos, CS, Snel, MH, van Rheenen, J	Curr Biol	2006