PI4P is dephosphorylated to PI by SACM1L at the ER membrane

Stable Identifier
R-HSA-1676124
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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PI4P is dephosphorylated to PI by SACM1L at the ER membrane
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At the endoplasmic reticulum (ER) membrane, transmembrane protein phosphatidylinositide phosphatase SAC1 (SACM1L) efficiently dephosphorylates phosphatidylinositol 4-phosphate (PI4P), and to a lesser extent phosphatidylinositol 3-phosphate (PI3P), to phosphatidylinositol (PI). No significant activity of this enzyme towards phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) was detected (Rohde et al. 2003).
Literature References
PubMed ID Title Journal Year
14527956 The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex

Paiha, K, Konrad, G, Rohde, HM, Boehmelt, G, Cheong, FY, Mayinger, P

J Biol Chem 2003
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Output
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as an event of
Catalyst Activity

phosphatidylinositol phosphate 4-phosphatase activity of SACM1L [endoplasmic reticulum membrane]

Physical Entity
SACM1L [endoplasmic reticulum membrane] (Homo sapiens)
Activity
phosphatidylinositol phosphate 4-phosphatase activity (GO:0034596)
Orthologous Events
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Bos taurus)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Caenorhabditis elegans)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Canis familiaris)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Danio rerio)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Dictyostelium discoideum)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Drosophila melanogaster)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Gallus gallus)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Mus musculus)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Plasmodium falciparum)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Rattus norvegicus)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Saccharomyces cerevisiae)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Schizosaccharomyces pombe)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Sus scrofa)
Cross References
Rhea
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
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