PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) and beta (PIP4K2B) homodimers and heterodimers (Clarke et al. 2010), along with phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2).

The following lists the above proteins with their corresponding literature references: PIP4K2A (Zhang et al. 1997, Rameh et al. 1997, Clarke et al. 2008), PIP4K2B (Zhang et al. 1997, Rameh et al. 1997), PIP5K1A (Zhang et al. 1997, Tolias et al. 1998), PIP5K1B (Zhang et al. 1997, Tolias et al. 1998), and PIP5K1C (Wenk et al. 2001, Di Paolo et al. 2002).

Literature References
PubMed ID Title Journal Year
9211928 Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules

Zhang, X, Loijens, JC, Boronenkov, IV, Parker, GJ, Norris, FA, Chen, J, Thum, O, Prestwich, GD, Majerus, PW, Anderson, RA

J Biol Chem 1997
9367159 A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

Rameh, LE, Tolias, KF, Duckworth, BC, Cantley, LC

Nature 1997
9660759 Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate

Tolias, KF, Rameh, LE, Ishihara, H, Shibasaki, Y, Chen, J, Prestwich, GD, Cantley, LC, Carpenter, CL

J Biol Chem 1998
19896968 Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases

Clarke, JH, Wang, M, Irvine, RF

Adv Enzyme Regul 2010
12422219 Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin

Di Paolo, G, Pellegrini, L, Letinic, K, Cestra, G, Zoncu, R, Voronov, S, Chang, S, Guo, J, Wenk, MR, De Camilli, P

Nature 2002
18753295 Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron

Clarke, JH, Emson, PC, Irvine, RF

Am J Physiol Renal Physiol 2008
11604140 PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse

Wenk, MR, Pellegrini, L, Klenchin, VA, Di Paolo, G, Chang, S, Daniell, L, Arioka, M, Martin, TF, De Camilli, P

Neuron 2001
Catalyst Activity

1-phosphatidylinositol-3-phosphate 4-kinase activity of PIP4K2/5K1 [cytosol]

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