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PACS1 [cytosol]
Stable Identifier
R-HSA-167634
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PACS-1
Locations in the PathwayBrowser for interactor UniProt:P23470 PTPRG
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
Nef mediated downregulation of MHC class I complex cell surface expression (Homo sapiens)
Degradation of MHC I Complex (Homo sapiens)
PACS1 [cytosol] (Homo sapiens)
Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
PACS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6VY07 PACS1
Gene Names
PACS1, KIAA1175
Chain
initiator methionine:, chain:2-963
Reference Genes
BioGPS Gene:55690 PACS1
COSMIC (genes):PACS1 PACS1
CTD Gene:55690 PACS1
dbSNP Gene:55690 PACS1
ENSEMBL:ENSG00000175115 PACS1
ENSEMBL_homo_sapiens_GENE:ENSG00000175115.13 PACS1
HGNC:30032 PACS1
KEGG Gene (Homo sapiens):55690 PACS1
Monarch:55690 PACS1
NCBI Gene:55690 PACS1
OMIM:607492 PACS1
UCSC:Q6VY07 PACS1
Reference Transcript
RefSeq:NM_018026.3 PACS1
Other Identifiers
11717030_x_at
11749799_a_at
16727277
220557_3p_s_at
220557_PM_s_at
220557_s_at
224658_3p_x_at
224658_PM_x_at
224658_x_at
3335953
3335954
3335955
3335986
3335990
3335991
3335992
3335994
3335995
3335999
3336001
3336002
3336008
3336010
3336012
3336015
3336016
3336017
3336019
3336020
3336021
3336023
3336025
3336026
3336028
3336029
3336030
3336031
3336032
3336033
3336034
48875_at
55690
7941537
A_14_P111730
A_23_P500282
A_24_P69784
GE53812
GE82276
GO:0002260
GO:0002376
GO:0005515
GO:0005794
GO:0005829
GO:0030137
GO:0031410
GO:0034067
GO:0043226
GO:0044325
GO:0072659
HMNXSV003047612
Hs.260150.1.S1_3p_a_at
ILMN_1716488
PH_hs_0003768
TC11000654.hg
g8922284_3p_a_at
g8922284_3p_x_at
Participates
as an output of
Degradation of MHC I Complex (Homo sapiens)
as a component of
Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
as an input of
Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
Cross References
RefSeq
NP_060496.2
OpenTargets
ENSG00000175115
GeneCards
Q6VY07
HPA
ENSG00000175115-PACS1
Ensembl
ENSP00000316454
,
ENST00000320580
,
ENSG00000175115
PRO
Q6VY07
Pharos - Targets
Q6VY07
Orphanet
22011
HMDB Protein
HMDBP10752
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67870 CSNK2B
5
CSNK2B [secretory granule lumen]
(R-HSA-6801319)
CSNK2B [extracellular region]
(R-HSA-6806508)
CSNK2B [ficolin-1-rich granule lumen]
(R-HSA-6801290)
CSNK2B [nucleoplasm]
(R-HSA-6805067)
CSNK2B [cytosol]
(R-HSA-201693)
0.593
3
UniProt:A0A6Q8PF08 A0A6Q8PF08
0.556
3
UniProt:P54253 ATX1
0.556
6
IntAct:EBI-25865403 EHD27213144
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q92870-2 Q928702
0.556
3
UniProt:Q13148 TADBP
0.556
6
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
18
UniProt:Q9NZ52 GGA3
3
GGA3 [endosome membrane]
(R-HSA-5692936)
GGA3 [recycling endosome membrane]
(R-HSA-8875655)
GGA3 [early endosome membrane]
(R-HSA-8854137)
0.544
5
UniProt:P23470 PTPRG
0.534
2
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.527
2
UniProt:Q9Y2I8 WDR37
0.527
5
UniProt:Q15435 PP1R7
0.508
2
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