Reactome | RANBP1 [nuclear envelope]

RANBP1 [nuclear envelope]

Stable Identifier

R-HSA-167651

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

RanBP1

Locations in the PathwayBrowser for interactor UniProt:P18754 RCC1

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External Reference Information

External Reference

UniProt:P43487 RANBP1

Gene Names

RANBP1

Chain

initiator methionine:, chain:2-201

Reference Genes

BioGPS Gene:5902 RANBP1

COSMIC (genes):RANBP1 RANBP1

CTD Gene:5902 RANBP1

dbSNP Gene:5902 RANBP1

ENSEMBL:ENSG00000099901 RANBP1

HGNC:9847 RANBP1

KEGG:hsa:5902 RANBP1

Monarch:5902 RANBP1

NCBI Gene:5902 RANBP1

OMIM:601180 RANBP1

UCSC:P43487 RANBP1

Reference Transcript

Other Identifiers

11723001_s_at

11723002_x_at

11761851_a_at

16927198

202482_3p_x_at

202482_PM_x_at

202482_x_at

202483_PM_s_at

202483_s_at

2375758

3463102

3463103

3713605

3937229

3937230

3937231

3937232

3937233

3937234

3937235

3937236

3937237

3937238

3937239

3937240

3937241

3937242

3937243

3937244

3937245

3937246

3937247

3937248

3937249

3937251

4003279

4003280

41342_at

5902

64268_f_at

8071332

A_14_P105393

A_23_P91590

D38076_at

GE61238

GO:0005092

GO:0005096

GO:0005515

GO:0005634

GO:0005635

GO:0005643

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0006913

GO:0007010

GO:0007051

GO:0007165

GO:0031267

GO:0043226

GO:0045296

GO:0046604

GO:0046907

GO:0098772

HMNXSV003024350

HMNXSV003047560

Hs.24763.0.S1_3p_a_at

Hs.24763.0.S1_3p_at

ILMN_1721457

ILMN_2109156

PH_hs_0038434

g6382077_3p_a_at

Participates

as an input of

Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex (Homo sapiens)

as an output of

Release of the HIV mRNA and Crm1 from Rev in the cytoplasm (Homo sapiens)

as a component of

RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complex [cytosol] (Homo sapiens)

This entity regulates

Positively

Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)

Cross References

ENSEMBL

ENSP00000327583, ENSP00000384925, ENST00000402752, ENST00000331821

OpenTargets

ENSG00000099901

HPA

ENSG00000099901-RANBP1

PRO

P43487

Pharos - Targets

P43487

GlyGen

P43487

HMDB Protein

HMDBP08520

PDB

1K5G, 1K5D

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.77	6
UniProt:O00151 PDLI1			0.527	2
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.527	3
UniProt:P18754 RCC1	2	RCC1 [chromosome] (R-HSA-9668547) RCC1 [nucleoplasm] (R-HSA-180690)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9

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