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PLCG1 [plasma membrane]
Stable Identifier
R-HSA-167682
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Phospholipase C gamma 1, PLC1
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Netrin-1 signaling (Homo sapiens)
Role of second messengers in netrin-1 signaling (Homo sapiens)
Phosphorylation of PLCgamma by Netrin-1 (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
ALK fusion proteins bind PLCG1 (Homo sapiens)
PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
ALK fusions phosphorylate PLCG1 (Homo sapiens)
PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)
Activated FGFR1 mutants and fusions:PLCG1 [cytosol] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants and fusions phosphorylate PLCG1 (Homo sapiens)
Activated FGFR1 mutants and fusions:PLCG1 [cytosol] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by FGFR2 in disease (Homo sapiens)
Activated FGFR2 mutants bind PLCG1 (Homo sapiens)
Activated FGFR2 mutants:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants phosphorylate PLCG1 (Homo sapiens)
Activated FGFR2 mutants:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by FGFR3 in disease (Homo sapiens)
Activated FGFR3 point and translocation mutants bind PLCG1 (Homo sapiens)
Activated FGFR3 point and translocation mutants: PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR3 point and translocation mutants phosphorylate PLCG1 (Homo sapiens)
Activated FGFR3 point and translocation mutants: PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by FGFR4 in disease (Homo sapiens)
Activated FGFR4 mutants bind PLCG1 (Homo sapiens)
Activated FGFR4 mutants:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants phosphorylate PLCG1 (Homo sapiens)
Activated FGFR4 mutants:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)
PLCdegh [plasma membrane] (Homo sapiens)
PLCG1:Ca2+ [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
Active ALK binds PLCG1 (Homo sapiens)
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Active ALK phosphorylates PLCG1 (Homo sapiens)
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
Phospholipase C-mediated cascade: FGFR1 (Homo sapiens)
Activated FGFR1 binds PLCG1 (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
activated FGFR1:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 phosphorylates PLCG1 (Homo sapiens)
activated FGFR1:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
Downstream signaling of activated FGFR2 (Homo sapiens)
Phospholipase C-mediated cascade; FGFR2 (Homo sapiens)
Activated FGFR2 binds PLCG1 (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
activated FGFR2:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR2 phosphorylates PLCG1 (Homo sapiens)
activated FGFR2:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by FGFR3 (Homo sapiens)
Downstream signaling of activated FGFR3 (Homo sapiens)
Phospholipase C-mediated cascade; FGFR3 (Homo sapiens)
Activated FGFR3 binds PLCG1 (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
activated FGFR3:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR3 phosphorylates PLCG1 (Homo sapiens)
activated FGFR3:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
Phospholipase C-mediated cascade; FGFR4 (Homo sapiens)
Activated FGFR4 binds PLCG1 (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
PLC-gamma1 signalling (Homo sapiens)
Binding of PLCG1 to active TrkA receptor (Homo sapiens)
Active TrkA receptor:PLCG1 complex [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
TrkA phosphorylates PLCG1 (Homo sapiens)
Active TrkA receptor:PLCG1 complex [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through PLCG1 (Homo sapiens)
NTRK2 phosphorylates PLCG1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
p-Y817 of p-5Y-NTRK2 recruits PLCG1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by NTRK3 (TRKC) (Homo sapiens)
Activated NTRK3 signals through PLCG1 (Homo sapiens)
Activated NTRK3 binds PLCG1 (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
NTRK3 phosphorylates PLCG1 (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
PLC-gamma binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
Phosphorylation of PLCgamma by PDGFR (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
PLCG1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19174 PLCG1
Gene Names
PLCG1, PLC1
Chain
initiator methionine:, chain:2-1290
Reference Genes
BioGPS Gene:5335 PLCG1
COSMIC (genes):PLCG1 PLCG1
CTD Gene:5335 PLCG1
dbSNP Gene:5335 PLCG1
ENSEMBL:ENSG00000124181 PLCG1
ENSEMBL_homo_sapiens_GENE:ENSG00000124181.15 PLCG1
HGNC:9065 PLCG1
KEGG Gene (Homo sapiens):5335 PLCG1
Monarch:5335 PLCG1
NCBI Gene:5335 PLCG1
OMIM:172420 PLCG1
UCSC:P19174 PLCG1
Reference Transcript
RefSeq:NM_182811.1 PLCG1
RefSeq:NM_002660.2 PLCG1
Other Identifiers
1082_at
11723761_a_at
11723762_at
16913761
16913806
202789_PM_at
202789_at
216551_PM_x_at
216551_x_at
240805_PM_at
240805_at
34351_at
3885545
3885546
3885547
3885548
3885559
3885560
3885561
3885563
3885564
3885566
3885568
3885569
3885570
3885571
3885572
3885573
3885574
3885576
3885577
3885578
3885581
3885582
3885583
3885585
3885587
3885588
3885589
3885590
3885591
3885595
3885596
3885597
3885600
3885602
3885603
3885604
3885606
3885607
3885608
3885609
3885610
3885611
3885612
3885613
3885614
3885615
3885616
3885617
3885618
3885619
3885620
3885621
3885623
3885624
5335
8062623
81996_at
A_14_P119146
A_14_P134037
GE537103
GE81175
GE88032
GO:0001701
GO:0001726
GO:0002376
GO:0002862
GO:0003824
GO:0004435
GO:0004629
GO:0005085
GO:0005168
GO:0005509
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006629
GO:0006954
GO:0007165
GO:0007173
GO:0008081
GO:0008180
GO:0009395
GO:0010634
GO:0012501
GO:0016042
GO:0016477
GO:0016787
GO:0019722
GO:0019901
GO:0023052
GO:0030027
GO:0030971
GO:0032587
GO:0035254
GO:0035556
GO:0038095
GO:0042995
GO:0043226
GO:0043536
GO:0045766
GO:0046488
GO:0046872
GO:0048015
GO:0048856
GO:0048870
GO:0050429
GO:0050804
GO:0050852
GO:0050896
GO:0051209
GO:0051281
GO:0055065
GO:0055085
GO:0071364
GO:0098685
GO:0098772
GO:0098978
GO:1905564
GO:2000353
HMNXSV003018394
HMNXSV003030519
HMNXSV003044393
Hs.161402.0.A1_3p_at
Hs.268177.0.S2_3p_at
Hs.268177.1.S1_3p_a_at
ILMN_1740160
ILMN_2382906
M34667_at
PH_hs_0027331
TC20000303.hg
Participates
as a component of
PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane] (Homo sapiens)
Active TrkA receptor:PLCG1 complex [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
activated FGFR3:PLCG1 [plasma membrane] (Homo sapiens)
activated FGFR1:PLCG1 [plasma membrane] (Homo sapiens)
activated FGFR2:PLCG1 [plasma membrane] (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
PLCG1:Ca2+ [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:PLCG1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 mutants and fusions:PLCG1 [cytosol] (Homo sapiens)
Activated FGFR3 point and translocation mutants: PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR2 mutants:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 mutants:PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
as an input of
ALK fusion proteins bind PLCG1 (Homo sapiens)
Active ALK binds PLCG1 (Homo sapiens)
Binding of PLCG1 to active TrkA receptor (Homo sapiens)
PLC-gamma binds to the active receptor (Homo sapiens)
Activated FGFR3 binds PLCG1 (Homo sapiens)
Activated FGFR1 binds PLCG1 (Homo sapiens)
Activated FGFR2 binds PLCG1 (Homo sapiens)
Activated FGFR4 binds PLCG1 (Homo sapiens)
p-Y817 of p-5Y-NTRK2 recruits PLCG1 (Homo sapiens)
Activated NTRK3 binds PLCG1 (Homo sapiens)
Phosphorylation of PLCgamma by Netrin-1 (Homo sapiens)
Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)
Activated FGFR3 point and translocation mutants bind PLCG1 (Homo sapiens)
Activated FGFR2 mutants bind PLCG1 (Homo sapiens)
Activated FGFR4 mutants bind PLCG1 (Homo sapiens)
PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)
Other forms of this molecule
p-Y-PLCG1 [cytosol]
p-4Y-PLCG1 [plasma membrane]
PLCG1 [cytosol]
p-Y771,Y783,Y1254-PLCG1 [cytosol]
p-Y771,Y783-PLCG1 [plasma membrane]
Inferred To
PLCG1 [plasma membrane]
(Bos taurus)
PLCG1 [plasma membrane]
(Canis familiaris)
PLCG1 [plasma membrane]
(Dictyostelium discoideum)
PLCG1 [plasma membrane]
(Gallus gallus)
PLCG1 [plasma membrane]
(Mus musculus)
PLCG1 [plasma membrane]
(Plasmodium falciparum)
PLCG1 [plasma membrane]
(Rattus norvegicus)
PLCG1 [plasma membrane]
(Saccharomyces cerevisiae)
PLCG1 [plasma membrane]
(Schizosaccharomyces pombe)
PLCG1 [plasma membrane]
(Sus scrofa)
Ghost homologue of PLCG1 [plasma membrane]
(Caenorhabditis elegans)
sl [plasma membrane]
(Drosophila melanogaster)
plcg1 [plasma membrane]
(Danio rerio)
plcg1 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002651.2
,
NP_877963.1
Guide to Pharmacology - Targets
1407
OpenTargets
ENSG00000124181
ZINC - Substances
PLCG1_HUMAN
ZINC target
P19174
PRO
P19174
PDB
4EY0
,
2HSP
,
1HSQ
,
7NXE
,
4FBN
GeneCards
P19174
HPA
ENSG00000124181-PLCG1
Ensembl
ENST00000685551
,
ENSP00000508698
,
ENSG00000124181
,
ENSP00000244007
,
ENST00000373271
,
ENST00000244007
,
ENSP00000362368
Pharos - Targets
P19174
ZINC - Predictions - Purchasable
PLCG1_HUMAN
HMDB Protein
HMDBP00244
Interactors (39)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11362 FGFR1
9
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
FGFR1 [plasma membrane]
(R-HSA-9756433)
0.903
11
UniProt:P09619 PDGFRB
3
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.851
7
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.85
6
UniProt:O43561 LAT
3
p-Y200,Y220-LAT [plasma membrane]
(R-HSA-434829)
p-5Y-LAT [plasma membrane]
(R-HSA-202364)
LAT [plasma membrane]
(R-HSA-202322)
0.81
7
UniProt:P06213 INSR
6
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.799
9
UniProt:P21802-1 FGFR2
20
FGFR2c S252W [plasma membrane]
(R-HSA-2011852)
FGFR2c P253R [plasma membrane]
(R-HSA-1637916)
FGFR2c A315S [plasma membrane]
(R-HSA-2071931)
FGFR2c A314S [plasma membrane]
(R-HSA-2071928)
FGFR2c A314D [plasma membrane]
(R-HSA-1637888)
FGFR2c A315T [plasma membrane]
(R-HSA-1637889)
FGFR2c W290G [plasma membrane]
(R-HSA-2029883)
FGFR2c Y375C [plasma membrane]
(R-HSA-2029881)
FGFR2c S372C [plasma membrane]
(R-HSA-2029886)
p-8Y-FGFR2c S252W [plasma membrane]
(R-HSA-2011879)
p-8Y-FGFR2c P253R [plasma membrane]
(R-HSA-2011880)
p-8Y-FGFR2c A315S mutant [plasma membrane]
(R-HSA-2071942)
p-8Y-FGFR2c A314S [plasma membrane]
(R-HSA-2071944)
p-8Y-FGFR2c A314D [plasma membrane]
(R-HSA-2071946)
p-8Y-FGFR2c A315T [plasma membrane]
(R-HSA-2071940)
p-8Y-FGFR2c W290G [plasma membrane]
(R-HSA-2029862)
p-8Y-FGFR2c S372C [plasma membrane]
(R-HSA-2029865)
p-8Y-FGFR2c Y375C [plasma membrane]
(R-HSA-2029861)
FGFR2c long [plasma membrane]
(R-HSA-189920)
p-8Y-FGFR2c long [plasma membrane]
(R-HSA-190416)
0.698
9
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.692
3
UniProt:P10721 KIT
20
KIT C443Y [plasma membrane]
(R-HSA-9680045)
KIT T417_D419delinsY [plasma membrane]
(R-HSA-9680110)
KIT S476I [plasma membrane]
(R-HSA-9680090)
KIT K509I [plasma membrane]
(R-HSA-9680177)
KIT D419A [plasma membrane]
(R-HSA-9680051)
KIT D419del [plasma membrane]
(R-HSA-9680079)
KIT S501_A502dup [plasma membrane]
(R-HSA-9680105)
KIT D419G [plasma membrane]
(R-HSA-9680057)
KIT N505_F508dup [plasma membrane]
(R-HSA-9680085)
KIT C443S [plasma membrane]
(R-HSA-9680038)
KIT D419N [plasma membrane]
(R-HSA-9680071)
KIT S476N [plasma membrane]
(R-HSA-9680097)
KIT D419H [plasma membrane]
(R-HSA-9680066)
KIT V560_L576del [plasma membrane]
(R-HSA-9670336)
KIT Y823N [plasma membrane]
(R-HSA-9669591)
KIT Y823C [plasma membrane]
(R-HSA-9669585)
p6Y-KIT Y823D [plasma membrane]
(R-HSA-9669628)
p7Y-KIT D816V [plasma membrane]
(R-HSA-9669612)
p7Y-KIT K642E [plasma membrane]
(R-HSA-9669596)
p7Y-KIT N822K [plasma membrane]
(R-HSA-9669617)
0.675
31
UniProt:Q07889 SOS1
3
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [plasma membrane]
(R-HSA-983559)
SOS1 [cytosol]
(R-HSA-64847)
0.667
3
UniProt:Q92918 M4K1
0.664
6
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.639
7
UniProt:P09327 VILI
0.628
5
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.624
4
UniProt:Q9ULH1 ASAP1
1
ASAP1 [cytosol]
(R-HSA-5620905)
0.602
3
UniProt:O43150 ASAP2
0.602
3
UniProt:Q9UPX8 SHANK2
1
SHANK2 [cytosol]
(R-HSA-6794265)
0.602
4
UniProt:Q07890 SOS2
1
SOS2 [cytosol]
(R-HSA-167221)
0.602
4
UniProt:Q8TB24 RIN3
1
RIN3 [cytosol]
(R-HSA-8875292)
0.602
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.602
9
UniProt:P42684 ABL2
1
ABL2 [cytosol]
(R-HSA-375998)
0.602
4
UniProt:Q13094 LCP2
2
p-Y113,128,145-LCP2 [cytosol]
(R-HSA-202175)
LCP2 [cytosol]
(R-HSA-202306)
0.564
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.564
2
UniProt:Q9H1R2 DUS15
0.544
2
UniProt:Q9BYB0 SHANK3
1
SHANK3 [cytosol]
(R-HSA-6794277)
0.544
2
UniProt:Q15036 SNX17
0.544
2
UniProt:P16234 PDGFRA
20
PDGFRA L629P [plasma membrane]
(R-HSA-9673596)
PDGFRA N659K [plasma membrane]
(R-HSA-9671535)
PDGFRA T674I [plasma membrane]
(R-HSA-9673603)
PDGFRA S601P [plasma membrane]
(R-HSA-9673600)
PDGFRA Y288C [endoplasmic reticulum membrane]
(R-HSA-9671971)
PDGFRA Y375_K455del [endoplasmic reticulum membrane]
(R-HSA-9673609)
p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
(R-HSA-9672027)
p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane]
(R-HSA-9673634)
PDGFRA D842_M844del [plasma membrane]
(R-HSA-9671526)
PDGFRA D842Y [plasma membrane]
(R-HSA-9671956)
PDGFRA D842V [plasma membrane]
(R-HSA-9671549)
PDGFRA I843_D846del [plasma membrane]
(R-HSA-9671537)
PDGFRA D842_H845del [plasma membrane]
(R-HSA-9671545)
PDGFRA D842del [plasma membrane]
(R-HSA-9671538)
PDGFRA D842_I843delinsV [plasma membrane]
(R-HSA-9671563)
PDGFRA D846Y [plasma membrane]
(R-HSA-9671958)
PDGFRA D843_845del [plasma membrane]
(R-HSA-9671552)
PDGFRA D842_D846del [plasma membrane]
(R-HSA-9671547)
PDGFRA N848K [plasma membrane]
(R-HSA-9671961)
PDGFRA Y849C [plasma membrane]
(R-HSA-9671974)
0.544
3
UniProt:P31994 FCGR2B
1
FCGR2B [plasma membrane]
(R-HSA-197854)
0.544
2
UniProt:P21802 FGFR2
20
FGFR2 IIIa TM [extracellular region]
(R-HSA-8851703)
FGFR2 [plasma membrane]
(R-HSA-2023840)
FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853137)
FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
(R-HSA-8853154)
FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853123)
FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
(R-HSA-8853158)
FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
(R-HSA-8853150)
FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
(R-HSA-8853153)
FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
(R-HSA-8853139)
FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
(R-HSA-8853159)
FGFR2 N549H [plasma membrane]
(R-HSA-2033296)
FGFR2 N549K [plasma membrane]
(R-HSA-1637910)
FGFR2 K660N [plasma membrane]
(R-HSA-1637905)
FGFR2 K660M [plasma membrane]
(R-HSA-1637902)
FGFR2 K660E [plasma membrane]
(R-HSA-1637900)
FGFR2 S267P [plasma membrane]
(R-HSA-1637920)
FGFR2 L764Hfs*4 [plasma membrane]
(R-HSA-1637908)
FGFR2 W290C [plasma membrane]
(R-HSA-1637929)
p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853134)
p-6Y-FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853146)
0.528
3
UniProt:P78314 3BP2
0.527
2
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
0.525
2
UniProt:O14796 SH2D1B
1
SH2D1B [cytosol]
(R-HSA-5685187)
0.525
2
UniProt:Q9BZW8 CD244
1
CD244 [plasma membrane]
(R-HSA-197846)
0.525
2
UniProt:Q8N1K5-1 THEMIS
0.499
3
UniProt:P20273 CD22
3
NAc-CD22 [plasma membrane]
(R-HSA-5690736)
CD22 [plasma membrane]
(R-HSA-197703)
p-Y762,807,822-CD22 [plasma membrane]
(R-HSA-5690726)
0.499
2
UniProt:P07949 RET
2
RET [plasma membrane]
(R-HSA-8853797)
p-5Y-RET [plasma membrane]
(R-HSA-8854162)
0.483
2
UniProt:P30530 AXL
2
p-Y779,Y821-AXL [plasma membrane]
(R-HSA-5357460)
AXL [plasma membrane]
(R-HSA-197705)
0.462
2
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.462
3
UniProt:Q8N1K5 THMS1
0.462
4
UniProt:P43405 SYK
6
p-Y-SYK [cytosol]
(R-HSA-9705732)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
SYK [plasma membrane]
(R-HSA-139844)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
0.462
4
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