Reactome | Active PLCG1 hydrolyses PIP2

Active PLCG1 hydrolyses PIP2

Stable Identifier

R-HSA-167686

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytoplasmic side of plasma membrane, plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - Active PLCG1 hydrolyses PIP2 (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - VEGFR2 mediated cell proliferation (Homo sapiens)
        
        Active PLCG1 hydrolyses PIP2 (Homo sapiens)

General

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Inositol 1,4,5-triphosphate (IP3) is a second messenger produced by phospholipase C (PLC) metabolism of phosphoinositol 4,5-bisphosphate (PIP2) (Canossa et al. 2001).

Participants

Input

Output

Participates

as an event of

Catalyst Activity

phosphatidylinositol phospholipase C activity of p-4Y-PLCG1 [plasma membrane]

Physical Entity

p-4Y-PLCG1 [plasma membrane] (Homo sapiens)

Activity

phosphatidylinositol phospholipase C activity (GO:0004435)

Inferred From

Active Plcg1 hydrolyses PIP2 (Rattus norvegicus)

Authored

Nasi, S (2006-10-10)

Annibali, D (2006-10-10)

Reviewed

Greene, LA (2007-11-08)

Created

Jassal, B (2005-11-01)

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