Reactome | AP2B1 [plasma membrane]

AP2B1 [plasma membrane]

Stable Identifier

R-HSA-167690

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

AP-2 beta 2

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Retrograde neurotrophin signalling (Homo sapiens)
        
        Axonal transport of NGF:Trk complexes (Homo sapiens)
        
        Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
        
        Activated TrkA receptor complex:Clathrin-coated vesicle:dynein:dynactin complex [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
        
        Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)
        
        Activated TrkA receptor complex:Clathrin-coated vesicle [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
        
        Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
        
        Formation of clathrin-coated vesicle (Homo sapiens)
        
        Activated TrkA receptor complex:Clathrin-coated vesicle [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - Epsin family proteins bind ubiquitinated cargo (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP-2 complex [plasma membrane] (Homo sapiens)
        
        AP2B1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63010 AP2B1

Gene Names

AP2B1, ADTB2, CLAPB1

Chain

initiator methionine:1, chain:2-937

Reference Genes

BioGPS Gene:163 AP2B1

COSMIC (genes):AP2B1 AP2B1

CTD Gene:163 AP2B1

dbSNP Gene:163 AP2B1

ENSEMBL:ENSG00000006125 AP2B1

ENSEMBL:ENSG00000006125.18 AP2B1

HGNC:563 AP2B1

KEGG Gene (Homo sapiens):163 AP2B1

Monarch:163 AP2B1

NCBI Gene:163 AP2B1

OMIM:601025 AP2B1

UCSC:P63010 AP2B1

Reference Transcript

Other Identifiers

11716261_a_at

11716262_a_at

163

16833345

200612_PM_s_at

200612_s_at

200615_PM_s_at

200615_s_at

36161_at

3718683

3718684

3718686

3718696

3718700

3718703

3718706

3718707

3718708

3718709

3718710

3718712

3718713

3718714

3718715

3718717

3718718

3718721

3718722

3718723

3718724

3718725

3718730

3718732

3718735

3718739

3718740

3718741

4014722

4014723

4014724

4014729

4014731

4014733

4014735

4014738

8006542

A_23_P55149

A_24_P253827

GE57939

GO:0001822

GO:0003279

GO:0003281

GO:0005048

GO:0005515

GO:0005764

GO:0005768

GO:0005773

GO:0005829

GO:0005886

GO:0005905

GO:0006886

GO:0006897

GO:0007507

GO:0009898

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030122

GO:0030131

GO:0030276

GO:0030666

GO:0030669

GO:0031090

GO:0031410

GO:0035615

GO:0035904

GO:0036020

GO:0043226

GO:0045202

GO:0045334

GO:0048488

GO:0048856

GO:0060090

GO:0060976

GO:0072583

GO:0098793

GO:0098794

GO:0098884

GO:0098978

GO:0099590

HMNXSV003043367

Hs.74626.0.A1_3p_s_at

ILMN_1681998

ILMN_2331735

M34175_at

PH_hs_0024131

TC17000399.hg

g4557468_3p_a_at

Participates

as a component of

AP-2 complex [plasma membrane] (Homo sapiens)

Other forms of this molecule

AP2B1 [endolysosome membrane]

AP2B1 [clathrin-coated endocytic vesicle membrane]

AP2B1 [cytosol]

Inferred To

Ap2b1 [plasma membrane] (Mus musculus)

Ap2b1 [plasma membrane] (Rattus norvegicus)

AP-1-2beta [plasma membrane] (Drosophila melanogaster)

apl1 [plasma membrane] (Schizosaccharomyces pombe)

APL1 [plasma membrane] (Saccharomyces cerevisiae)

ap2b1 [plasma membrane] (Xenopus tropicalis)

Homologues of AP2B1 [plasma membrane] (Saccharomyces cerevisiae)

Homologues of AP2B1 [plasma membrane] (Schizosaccharomyces pombe)

apb-1 [plasma membrane] (Caenorhabditis elegans)

fa16e07 [plasma membrane] (Danio rerio)

ap1b1 [plasma membrane] (Dictyostelium discoideum)

AP2B1 [plasma membrane] (Bos taurus)

AP2B1 [plasma membrane] (Canis familiaris)

AP2B1 [plasma membrane] (Gallus gallus)

AP2B1 [plasma membrane] (Sus scrofa)

APL2 [plasma membrane] (Saccharomyces cerevisiae)

apl2 [plasma membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_016879773.1, XP_005257995.1, XP_005257994.1, NP_001273.1, XP_016879775.1, XP_011522757.1, NP_001025177.1

OpenTargets

ENSG00000006125

HPA

ENSG00000006125-AP2B1

GeneCards

P63010

Ensembl

ENSG00000006125, ENST00000618940, ENST00000621914, ENSP00000483185, ENSP00000482315, ENST00000610402, ENSP00000482835

PRO

P63010

Pharos - Targets

P63010

PDB

6QH5, 5M5R, 6QH7, 2IV8, 2JKR, 7OHO, 6YAF, 6YAI, 2XA7, 2G30, 2VGL, 6QH6, 7OG1, 7OM8, 2IV9, 2JKT, 6URI, 7Z5C, 6YAH, 6YAE, 4UQI, 1E42

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5SW96 LDLRAP1	2	LDLRAP1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869097) LDLRAP1 [plasma membrane] (R-HSA-171143)	0.681	4
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.678	3
UniProt:P12236 SLC25A6	2	SLC25A6 [mitochondrial intermembrane space] (R-HSA-1955374) SLC25A6 [mitochondrial inner membrane] (R-HSA-49745)	0.666	4
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.592	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.569	5
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.556	3
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P29353 SHC1	5	SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.527	3

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