Reactome | HCK [cytosol]

HCK [cytosol]

Stable Identifier

R-HSA-167708

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Hck-1

Locations in the PathwayBrowser for interactor UniProt:Q07889 SOS1

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External Reference Information

External Reference

UniProt:P08631 HCK

Gene Names

HCK

Chain

initiator methionine:, chain:2-526, initiator methionine:

Reference Genes

COSMIC (genes):HCK HCK

dbSNP Gene:3055 HCK

ENSEMBL:ENSG00000101336 HCK

Participates

as a member of

as an input of

as a component of

as a candidate of

FYN-like kinases [cytosol] (Homo sapiens)

Other forms of this molecule

p-HCK [cytosol]

Inferred To

HCK [cytosol] (Bos taurus)

HCK [cytosol] (Caenorhabditis elegans)

HCK [cytosol] (Canis familiaris)

HCK [cytosol] (Drosophila melanogaster)

HCK [cytosol] (Gallus gallus)

HCK [cytosol] (Mus musculus)

HCK [cytosol] (Rattus norvegicus)

HCK [cytosol] (Sus scrofa)

HCK [cytosol] (Xenopus tropicalis)

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.78	4
UniProt:P27958 POLG	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.729	5
UniProt:P42768 WAS	2	p-Y291-WAS [cytosol] (R-HSA-2197668) WAS [cytosol] (R-HSA-201879)	0.718	9
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.713	4
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.709	4
UniProt:Q07889 SOS1	3	SOS1 [cytosol] (R-HSA-64847) SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821)	0.692	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.669	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.653	3
UniProt:P03407 NEF			0.646	4
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.609	2
UniProt:O92972 POLG			0.589	2
IntAct:EBI-7149158 PD1			0.558	2
UniProt:O43184 ADAM12	1	ADAM12 [plasma membrane] (R-HSA-179792)	0.558	2
UniProt:P04324 NEF			0.558	2
UniProt:Q9HD26 GOPC	3	GOPC [lysosomal membrane] (R-HSA-5627281) GOPC [plasma membrane] (R-HSA-5626572) GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:P03406 NEF			0.542	2
UniProt:P07948 LYN	7	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [plasma membrane] (R-HSA-2454229) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903)	0.527	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.527	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	3
UniProt:P12504 VIF			0.524	3
IntAct:EBI-7355238 Q85737			0.524	3
UniProt:Q9QPN3 NEF			0.524	3
UniProt:Q92556 ELMO1	1	ELMO1 [cytosol] (R-HSA-200932)	0.524	4
UniProt:Q90VU7 Q90VU7			0.524	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.524	2
UniProt:P59046 NLRP12	5	NLRP12(241-1061) [cytosol] (R-HSA-9729690) NLRP12(1-937) [cytosol] (R-HSA-9729744) NLRP12(938-1061) [cytosol] (R-HSA-9729702) NLRP12(1-240) [cytosol] (R-HSA-9729718) NLRP12 [cytosol] (R-HSA-561195)	0.508	4