IDS hydrolyses Heparan sulfate chain(5)

Stable Identifier
R-HSA-1678650
Type
Reaction [transition]
Species
Homo sapiens
Compartment
lysosomal lumen
ReviewStatus
5/5
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IDS hydrolyses Heparan sulfate chain(5)
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Iduronate 2sulfatase (IDS) hydrolyses 2-sulfate groups from Liduronate 2-sulfate units of heparan sulfate. Defects in IDS are the cause of mucopolysaccharidosis type II (MPSII, MIM:309900), also called Hunter syndrome (Wilson et al. 1990).
Literature References
PubMed ID Title Journal Year
2122463 Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA

Morris, CP, Bielicki, J, Occhiodoro, T, Hopwood, JJ, Anson, DS, Clements, PR, Wilson, PJ

Proc Natl Acad Sci U S A 1990
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Catalyst Activity

iduronate-2-sulfatase activity of IDS dimer [lysosomal lumen]

Physical Entity
IDS dimer [lysosomal lumen] (Homo sapiens)
Activity
iduronate-2-sulfatase activity (GO:0004423)
Orthologous Events
IDS hydrolyses Heparan sulfate chain(5) (Bos taurus)
IDS hydrolyses Heparan sulfate chain(5) (Canis familiaris)
IDS hydrolyses Heparan sulfate chain(5) (Danio rerio)
IDS hydrolyses Heparan sulfate chain(5) (Drosophila melanogaster)
IDS hydrolyses Heparan sulfate chain(5) (Gallus gallus)
IDS hydrolyses Heparan sulfate chain(5) (Mus musculus)
IDS hydrolyses Heparan sulfate chain(5) (Rattus norvegicus)
IDS hydrolyses Heparan sulfate chain(5) (Sus scrofa)
IDS hydrolyses Heparan sulfate chain(5) (Xenopus tropicalis)
Authored
Jassal, B  (2011-10-19)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-10-19)
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