Reactome | EIF4E2 [cytosol]

EIF4E2 [cytosol]

Stable Identifier

R-HSA-1678822

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

4EHP, Eukaryotic translation initiation factor 4E type 2, IF4E2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O60573 EIF4E2

Gene Names

EIF4E2, EIF4EL3

Chain

chain:1-245

Reference Genes

COSMIC (genes):EIF4E2 EIF4E2

dbSNP Gene:9470 EIF4E2

ENSEMBL:ENSG00000135930 EIF4E2

Participates

as a component of

ISGylated 4EHP [cytosol] (Homo sapiens)

as an input of

ISGylation of protein translation regulator 4EHP (Homo sapiens)

Inferred To

eIF4EHP [cytosol] (Drosophila melanogaster)

ife-4 [cytosol] (Caenorhabditis elegans)

MGC89871 [cytosol] (Xenopus tropicalis)

EIF4E2 [cytosol] (Bos taurus)

EIF4E2 [cytosol] (Dictyostelium discoideum)

EIF4E2 [cytosol] (Gallus gallus)

EIF4E2 [cytosol] (Mus musculus)

EIF4E2 [cytosol] (Plasmodium falciparum)

EIF4E2 [cytosol] (Sus scrofa)

Homologues of EIF4E2 [cytosol] (Bos taurus)

Homologues of EIF4E2 [cytosol] (Dictyostelium discoideum)

Homologues of EIF4E2 [cytosol] (Plasmodium falciparum)

LOC611215 [cytosol] (Canis familiaris)

Ghost homologue of EIF4E2 [cytosol] (Rattus norvegicus)

eIF4e3 [cytosol] (Dictyostelium discoideum)

eif4e2 [cytosol] (Danio rerio)

Interactors (50)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRA8 4ET			0.778	6
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.725	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.725	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:P15173 MYOG	1	MYOG [nucleoplasm] (R-HSA-445160)	0.666	4
UniProt:Q96C00 ZBTB9			0.666	4
UniProt:P0C6X7-PRO_0000037310 REP			0.643	3
UniProt:O75420 GGYF1			0.638	4
UniProt:Q13541 EIF4EBP1	2	p-T37,T46-EIF4EBP1 [cytosol] (R-HSA-165685) EIF4EBP1 [cytosol] (R-HSA-72580)	0.564	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:Q9H257 CARD9	3	CARD9 [cytosol] (R-HSA-561194) p-T231-CARD9 [plasma membrane] (R-HSA-5607623) CARD9 [plasma membrane] (R-HSA-5607662)	0.556	3
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q8NA61 CBY2			0.556	3
UniProt:P60370 KRTAP10-5	1	KRTAP10-5 [cytosol] (R-HSA-6810260)	0.556	3
UniProt:Q70EL1 UBP54			0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:A1A4E9 A1A4E9			0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q9Y2J4-4 AMOTL2			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Cerebral CLONE			0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q8TD10 MIPO1			0.556	3
UniProt:O43597 SPRY2	8	p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) SPRY2 [cytosol] (R-HSA-182949) SPRY2 [plasma membrane] (R-HSA-182924) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-Y55-SPRY2 [cytosol] (R-HSA-182950)	0.556	3
UniProt:Q01850 CDR2			0.556	3
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3
UniProt:Q5T124 UBXN11	1	UBXN11 [cytosol] (R-HSA-9696514)	0.556	3
UniProt:Q9UPY8 MARE3			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q96R06 SPAG5			0.556	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:O60516 4EBP3			0.547	2
UniProt:P0DTD1-PRO_0000449620 REP			0.527	2
UniProt:Q13542 4EBP2			0.527	3
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.527	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:Q6Y7W6 GGYF2			0.508	3
UniProt:Q99814 EPAS1 (HIF2A)	5	EPAS1 [cytosol] (R-HSA-1234119) EPAS1 [nucleoplasm] (R-HSA-452560) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151) HN-EPAS1 [cytosol] (R-HSA-1234112)	0.499	2
UniProt:Q99750 MDFI			0.488	2

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