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UNC93B1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-1678930
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Unc93 homolog B1
Icon
Locations in the PathwayBrowser for interactor UniProt:P55060 XPO2
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Trafficking and processing of endosomal TLR (Homo sapiens)
Full-length TLR3/7/8/9 binds to UNC93B1 (Homo sapiens)
UNC93B1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H1C4 UNC93B1
Gene Names
UNC93B1, UNC93, UNC93B
Chain
chain:1-597
Reference Genes
BioGPS Gene:81622 UNC93B1
COSMIC (genes):UNC93B1 UNC93B1
CTD Gene:81622 UNC93B1
dbSNP Gene:81622 UNC93B1
ENSEMBL:ENSG00000110057 UNC93B1
ENSEMBL_homo_sapiens_GENE:ENSG00000110057.9 UNC93B1
HGNC:13481 UNC93B1
KEGG Gene (Homo sapiens):81622 UNC93B1
Monarch:81622 UNC93B1
NCBI Gene:81622 UNC93B1
OMIM:608204 UNC93B1
UCSC:Q9H1C4 UNC93B1
Reference Transcript
RefSeq:NM_030930.3 UNC93B1
Other Identifiers
11721322_at
16741173
17100833
220998_PM_s_at
220998_s_at
225869_PM_s_at
225869_s_at
2683250
2683252
2718105
2718108
2718113
2758606
2758607
2758608
2758633
2758635
2758636
3037672
3037673
3037682
3339081
3339082
3339084
3379132
3379270
3379271
3379272
3379273
3379276
3379277
3379280
3379282
3379285
3379286
3379290
3379291
3379292
3379294
3379296
3379297
3379298
49533_at
78054_at
7949904
8094144
8138147
81622
A_23_P98167
A_33_P3262758
GE61081
GO:0000139
GO:0000902
GO:0002224
GO:0002250
GO:0002376
GO:0002457
GO:0005515
GO:0005764
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0006886
GO:0016020
GO:0019882
GO:0019886
GO:0023052
GO:0031410
GO:0032009
GO:0032735
GO:0032755
GO:0034138
GO:0034154
GO:0034162
GO:0035325
GO:0043226
GO:0045087
GO:0045335
GO:0048856
GO:0051607
GO:0098542
HMNXSV003014560
Hs.135187.1.A1_3p_s_at
ILMN_1654812
ILMN_2193591
PH_hs_0027846
TC11001999.hg
g13569892_3p_s_at
Participates
as an input of
Full-length TLR3/7/8/9 binds to UNC93B1 (Homo sapiens)
as a component of
intracellular TLR:UNC93B1 [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
UNC93B1 [Golgi membrane]
UNC93B1 P345Pfs*103 [endoplasmic reticulum membrane]
UNC93B1 L230Afs*188 [endoplasmic reticulum membrane]
Inferred To
Unc93b1 [endoplasmic reticulum membrane]
(Mus musculus)
Unc93b1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
UNC93B1 [endoplasmic reticulum membrane]
(Bos taurus)
UNC93B1 [endoplasmic reticulum membrane]
(Canis familiaris)
UNC93B1 [endoplasmic reticulum membrane]
(Gallus gallus)
UNC93B1 [endoplasmic reticulum membrane]
(Sus scrofa)
unc93b1 [endoplasmic reticulum membrane]
(Danio rerio)
unc93b1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_112192.2
OpenTargets
ENSG00000110057
HPA
ENSG00000110057-UNC93B1
GeneCards
Q9H1C4
Ensembl
ENSP00000227471
,
ENSG00000110057
,
ENST00000227471
PRO
Q9H1C4
Pharos - Targets
Q9H1C4
Orphanet
15695
PDB
7C76
,
7CYN
Interactors (37)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P37268 FDFT1
1
FDFT1 [endoplasmic reticulum membrane]
(R-HSA-191369)
0.643
3
UniProt:Q9NR97 TLR8
4
TLR8 [endoplasmic reticulum membrane]
(R-HSA-1678947)
TLR8 [endolysosome membrane]
(R-HSA-167927)
TLR8 [Golgi membrane]
(R-HSA-1678918)
TLR8 [endosome membrane]
(R-HSA-1679577)
0.602
4
UniProt:Q9H7V2 SYNG1
0.556
3
UniProt:Q5T700 LRAD1
0.556
3
UniProt:P11912 CD79A
2
p-Y188,Y199-CD79A [plasma membrane]
(R-HSA-983539)
CD79A [plasma membrane]
(R-HSA-197154)
0.556
3
UniProt:Q9GZY8-5 MFF
0.556
3
UniProt:Q8WWF3 SSMM1
0.556
3
UniProt:Q9NZD1 GPC5D
0.556
3
UniProt:Q9NQQ7-3 Q9NQQ73
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:Q9H400 LIME1
0.556
3
UniProt:Q8WV48 CC107
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
IntAct:EBI-23184686 CCSB ORF ID
0.556
3
UniProt:O95471 CLDN7
2
CLDN7 [cell junction]
(R-HSA-421241)
CLDN7 [plasma membrane]
(R-HSA-420004)
0.556
3
UniProt:O60883 GPR37L1
1
GPR37L1 [plasma membrane]
(R-HSA-5336178)
0.556
3
UniProt:A8MZ59 LEUTX
1
LEUTX [nucleoplasm]
(R-HSA-9817277)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:P26715 KLRC1
1
KLRC1 [plasma membrane]
(R-HSA-3006545)
0.556
3
UniProt:O14843 FFAR3
1
FFAR3 [plasma membrane]
(R-HSA-443951)
0.556
3
UniProt:Q9UM44 HHLA2
0.556
3
UniProt:Q8NFU1 BEST2
1
BEST2 [plasma membrane]
(R-HSA-2744359)
0.556
3
UniProt:Q969F0 FATE1
0.556
3
UniProt:Q96Q45-2 TMEM237
0.556
3
UniProt:Q9H902 REEP1
1
REEP1 [endoplasmic reticulum membrane]
(R-HSA-8939766)
0.556
3
UniProt:Q96P66 GP101
0.556
3
UniProt:Q96CE8 T4S18
0.556
3
UniProt:Q9GZM5 YIPF3
0.527
2
UniProt:Q96AQ6 PBIP1
0.527
2
UniProt:P18859 ATP5PF
1
ATP5PF [mitochondrial inner membrane]
(R-HSA-164532)
0.527
2
UniProt:P36542 ATP5F1C
1
ATP5F1C [mitochondrial matrix]
(R-HSA-164577)
0.527
2
UniProt:O95831 AIFM1
0.527
2
UniProt:Q96ER3 SAAL1
0.527
2
UniProt:P24539 ATP5PB
1
ATP5PB [mitochondrial inner membrane]
(R-HSA-164537)
0.527
2
UniProt:P55060 XPO2
0.499
2
UniProt:P0DTD8 NS7B
0.499
2
UniProt:Q14974 KPNB1
5
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [cytosol]
(R-HSA-180733)
0.499
2
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