Reactome | CHUK [cytosol]

CHUK [cytosol]

Stable Identifier

R-HSA-168104

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IKKA, IKK1, Inhibitor of nuclear factor kappa-B kinase alpha subunit

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Locations in the PathwayBrowser for interactor UniProt:P24772 PG200

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External Reference Information

External Reference

UniProt:O15111 CHUK

Gene Names

CHUK, IKKA, TCF16

Chain

chain:1-745

Reference Genes

BioGPS Gene:1147 CHUK

COSMIC (genes):CHUK CHUK

CTD Gene:1147 CHUK

dbSNP Gene:1147 CHUK

ENSEMBL:ENSG00000213341 CHUK

HGNC:1974 CHUK

KEGG:hsa:1147 CHUK

Monarch:1147 CHUK

NCBI Gene:1147 CHUK

OMIM:600664 CHUK

UCSC:O15111 CHUK

Reference Transcript

RefSeq:NM_001278.4 CHUK

Other Identifiers

1147

11754797_a_at

16717469

209666_PM_s_at

209666_s_at

3303298

3303299

3303301

3303302

3303303

3303304

3303307

3303308

3303309

3303310

3303311

3303312

3303313

3303314

3303315

3303316

3303320

3303321

3303322

3303324

3303325

3303326

3303327

3303328

3303329

3303330

3303331

3303332

3303333

3303334

3303335

3303336

3303337

3303338

33770_at

7935707

A_23_P46748

A_33_P3258141

GE62511

GE63120

GE81000

GO:0002376

GO:0003009

GO:0003012

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006468

GO:0006954

GO:0006955

GO:0007249

GO:0007252

GO:0008384

GO:0008385

GO:0009410

GO:0009615

GO:0009636

GO:0009653

GO:0009898

GO:0010034

GO:0010628

GO:0016740

GO:0030154

GO:0032088

GO:0032727

GO:0033194

GO:0033209

GO:0034142

GO:0034614

GO:0035631

GO:0038061

GO:0042803

GO:0043123

GO:0043200

GO:0043226

GO:0044877

GO:0045087

GO:0045893

GO:0045944

GO:0046982

GO:0051092

GO:0051146

GO:0061847

GO:0071276

GO:0071356

GO:0097110

GO:0098542

GO:0098586

GO:0140096

GO:1990459

HMNXSV003015828

ILMN_1677041

PH_hs_0011697

TC10002931.hg

g4185272_3p_s_at

Participates

as a component of

as an input of

as an output of

TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)

Other forms of this molecule

p-S176,S180-CHUK [cytosol]

p-T23-CHUK [cytosol]

p-Y187,Y198-CHUK [cytosol]

Inferred To

CHUK [cytosol] (Bos taurus)

CHUK [cytosol] (Canis familiaris)

CHUK [cytosol] (Danio rerio)

CHUK [cytosol] (Drosophila melanogaster)

CHUK [cytosol] (Gallus gallus)

CHUK [cytosol] (Mus musculus)

CHUK [cytosol] (Rattus norvegicus)

CHUK [cytosol] (Sus scrofa)

CHUK [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001269.3

ZINC - World Drugs

IKKA_HUMAN

Guide to Pharmacology - Targets

1989

ENSEMBL

ENST00000370397, ENSP00000359424

OpenTargets

ENSG00000213341

ZINC - FDA approved

IKKA_HUMAN

ZINC - Substances

IKKA_HUMAN

ZINC - Biogenic

IKKA_HUMAN

ZINC target

O15111

PRO

O15111

GlyGen

O15111

PDB

3BRT, 5EBZ, 5TQW, 5TQY, 5TQX

ZINC - Investigational

IKKA_HUMAN

IntEnz

2.7.11.10

HPA

ENSG00000213341-CHUK

Pharos - Targets

O15111

Orphanet

CHUK

ZINC - Predictions - Purchasable

IKKA_HUMAN

HMDB Protein

HMDBP02038

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.972	31
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.956	21
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.954	16
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.946	14
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.886	9
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.784	6
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.779	4
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.669	4
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.669	3
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) p-T187-MAP3K7 [cytosol] (R-HSA-206014) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.65	3
UniProt:P24772 PG200			0.623	3
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.609	2
UniProt:Q7Z406 MYH14	1	MYH14 [cytosol] (R-HSA-419176)	0.564	2
UniProt:Q15653 NFKBIB	3	p-S19,S23-Ub-NFKBIB [cytosol] (R-HSA-1168571) p-S19,S23-NFKBIB [cytosol] (R-HSA-177670) NFKBIB [cytosol] (R-HSA-168132)	0.564	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.544	2
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.536	2
UniProt:Q6ZSG2 INSY2			0.527	2
UniProt:Q5TCX8 M3K21			0.524	2
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) SMAD2 [cytosol] (R-HSA-3006353) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) Ub,p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-9773843) SMAD2 [nucleoplasm] (R-HSA-3006352) p-S250-SMAD2 [cytosol] (R-HSA-9731121) SMAD2 Q429* [cytosol] (R-HSA-9668727) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 S296* [cytosol] (R-HSA-9668729)	0.524	2
UniProt:Q86WI3 NLRC5	2	K63polyUb-NLRC5 [cytosol] (R-HSA-9750938) NLRC5 [cytosol] (R-HSA-937324)	0.524	3
UniProt:Q9ULZ3 PYCARD	4	PYCARD [cytosol] (R-HSA-561191) PYCARD [secretory granule lumen] (R-HSA-6800957) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [azurophil granule lumen] (R-HSA-6798768)	0.512	5
UniProt:P71451 INLC			0.509	3
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.483	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.463	3

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