Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
IKBKG [cytosol]
Stable Identifier
R-HSA-168108
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NEMO, IKKG, IKK-gamma, Inhibitor of nuclear factor kappa-B kinase gamma subunit
Icon
Locations in the PathwayBrowser for interactor UniProt:Q13535 ATR
Expand all
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
IKBKB deficiency causes SCID (Homo sapiens)
Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
RIP2 binds NEMO (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6K9 IKBKG
Gene Names
IKBKG, FIP3, NEMO
Chain
chain:1-419
Reference Genes
BioGPS Gene:8517 IKBKG
COSMIC (genes):IKBKG IKBKG
CTD Gene:8517 IKBKG
dbSNP Gene:8517 IKBKG
ENSEMBL:ENSG00000269335 IKBKG
ENSEMBL_homo_sapiens_GENE:ENSG00000269335.7 IKBKG
HGNC:5961 IKBKG
KEGG Gene (Homo sapiens):8517 IKBKG
Monarch:8517 IKBKG
NCBI Gene:8517 IKBKG
OMIM:300248 IKBKG
UCSC:Q9Y6K9 IKBKG
Reference Transcript
RefSeq:NM_001321396.1 IKBKG
RefSeq:NM_001099856.4 IKBKG
RefSeq:NM_001099857.2 IKBKG
RefSeq:NM_001321397.1 IKBKG
RefSeq:NM_003639.4 IKBKG
RefSeq:NM_001145255.2 IKBKG
Other Identifiers
11755328_a_at
11755329_x_at
11756119_a_at
11756120_x_at
11756123_a_at
11756124_x_at
11756384_a_at
11756385_x_at
17108468
209929_PM_s_at
209929_s_at
36004_3p_at
36004_PM_at
36004_at
3996552
3996553
3996554
3996556
3996557
3996558
3996559
3996560
3996561
3996562
3996563
3996564
3996565
3996569
3996572
3996573
3996578
3996579
3996581
3996583
3996584
3996585
3996586
3996587
3996588
3996589
3996590
4027476
4027477
4027478
4027479
4027480
4027483
4027484
4027489
4027490
4027492
4027574
8170955
8517
A_23_P159920
GE54691
GO:0000151
GO:0000922
GO:0002376
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0006351
GO:0006355
GO:0006914
GO:0006915
GO:0006954
GO:0006955
GO:0006974
GO:0007249
GO:0008385
GO:0009615
GO:0012501
GO:0016239
GO:0019904
GO:0023052
GO:0030163
GO:0031593
GO:0031625
GO:0032991
GO:0035591
GO:0042742
GO:0042802
GO:0042803
GO:0043123
GO:0043226
GO:0043276
GO:0045087
GO:0045944
GO:0046872
GO:0046982
GO:0050852
GO:0050862
GO:0051092
GO:0051650
GO:0060090
GO:0065003
GO:0070530
GO:0072686
GO:0098542
GO:1990450
GO:1990459
GO:2000060
HMNXSV003001956
HMNXSV003012514
ILMN_1707308
PH_hs_0027638
TC0X001541.hg
TC0X001941.hg
g5031140_3p_s_at
Participates
as a member of
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Homo sapiens)
as an input of
Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
RIP2 binds NEMO (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
as a component of
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Homo sapiens)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Homo sapiens)
Active IKK complex [cytosol] (Homo sapiens)
IKBKG:N4BP1 [cytosol] (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Homo sapiens)
CHUK:IKBKB:IKBKG [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
Other forms of this molecule
IKBKG D406V [cytosol]
IKBKG L153R [cytosol]
IKBKG E391* [cytosol]
IKBKG C417R [cytosol]
IKBKG R173G [cytosol]
IKBKG R175P [cytosol]
IKBKG *420Wext*447 [cytosol]
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
IKBKG [nucleoplasm]
K63polyUb-IKBKG [cytosol]
Ub-285-IKBKG [cytosol]
Inferred To
Homologues of IKBKG [cytosol]
(Rattus norvegicus)
Ikbkg [cytosol]
(Rattus norvegicus)
IKBKG [cytosol]
(Bos taurus)
IKBKG [cytosol]
(Canis familiaris)
IKBKG [cytosol]
(Drosophila melanogaster)
IKBKG [cytosol]
(Mus musculus)
IKBKG [cytosol]
(Rattus norvegicus)
IKBKG [cytosol]
(Sus scrofa)
ikbkg [cytosol]
(Danio rerio)
ikbkg [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001138727.1
,
NP_001308325.1
,
NP_001093327.1
,
NP_003630.1
,
NP_001093326.2
,
NP_001308326.1
OpenTargets
ENSG00000269335
GeneCards
Q9Y6K9
HPA
ENSG00000269335-IKBKG
ZINC - Substances
NEMO_HUMAN
ZINC target
Q9Y6K9
Ensembl
ENSP00000479662
,
ENSP00000471166
,
ENSP00000394934
,
ENSP00000395205
,
ENSP00000478616
,
ENST00000611176
,
ENST00000611071
,
ENSP00000390368
,
ENST00000618670
,
ENST00000422680
,
ENSP00000483825
,
ENST00000445622
,
ENST00000440286
,
ENST00000594239
,
ENSG00000269335
PRO
Q9Y6K9
Pharos - Targets
Q9Y6K9
ZINC - Predictions - Purchasable
NEMO_HUMAN
Orphanet
16252
PDB
2JVY
,
2JVX
,
4BWN
,
6MI3
,
3FX0
,
7TV4
,
3CL3
,
3BRT
,
6XX0
,
7T2U
,
6MI4
,
5AAY
,
6YEK
,
5LDE
,
3BRV
Interactors (73)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.982
40
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.972
31
UniProt:Q13546 RIPK1
20
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 [plasma membrane]
(R-HSA-937073)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-HSA-9796639)
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-HSA-9818793)
K63,M1polyUb-RIPK1 [cytosol]
(R-HSA-9793681)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-HSA-9818391)
K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-HSA-9817377)
p-S320-RIPK1 [cytosol]
(R-HSA-9815498)
p-S357-RIPK1 [cytosol]
(R-HSA-9819116)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
RIPK1 [endosome membrane]
(R-HSA-450326)
RIPK1 [cytosol]
(R-HSA-168651)
0.893
9
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.878
10
UniProt:Q9BYM8 RBCK1
1
RBCK1 [cytosol]
(R-HSA-976018)
0.858
9
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.848
9
UniProt:P25963 NFKBIA
9
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.845
6
IntAct:EBI-4399559 UBIQ
0.829
8
UniProt:Q9H0F6 SHARPIN
1
SHARPIN [cytosol]
(R-HSA-5212666)
0.818
14
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.813
6
UniProt:O95999 BCL10
3
K48polyUb-BCL10 [cytosol]
(R-HSA-8939329)
BCL10 [cytosol]
(R-HSA-202447)
p-BCL10 [cytosol]
(R-HSA-202488)
0.789
7
UniProt:Q96EP0 RNF31
1
RNF31 [cytosol]
(R-HSA-5212660)
0.773
10
UniProt:Q9UHD2 TBK1
5
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-TBK1 [cytosol]
(R-HSA-9008705)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
TBK1 [cytosol]
(R-HSA-166267)
p-S172-TBK1 [cytosol]
(R-HSA-168379)
0.77
5
UniProt:Q8NFZ5 TNIP2
1
TNIP2 [cytosol]
(R-HSA-451661)
0.764
8
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.75
4
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
0.744
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.744
5
UniProt:Q15025 TNIP1
1
TNIP1 [cytosol]
(R-HSA-5690853)
0.709
6
IntAct:EBI-15701099 IKKALPHA/BETA
0.695
6
UniProt:P01375 TNF
5
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.669
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.669
4
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.666
4
UniProt:Q92844 TANK
2
TANK [cytosol]
(R-HSA-933407)
K63polyUb-TANK [cytosol]
(R-HSA-5362480)
0.659
6
UniProt:Q9UDY8 MALT1
1
MALT1 [cytosol]
(R-HSA-202461)
0.656
4
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.643
4
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.641
4
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.633
4
UniProt:Q14161 GIT2
1
GIT2 [cytosol]
(R-HSA-446034)
0.618
6
UniProt:Q8VSC3 IPA9
0.616
8
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.615
3
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.609
2
UniProt:P24772 PG200
0.597
3
UniProt:Q9HC62 SENP2
1
SENP2 [nucleoplasm]
(R-HSA-2984298)
0.581
3
UniProt:P05937 CALB1
1
CALB1 [cytosol]
(R-HSA-2980899)
0.581
3
UniProt:Q9UBF6 RNF7
1
RNF7 (RBX2) [cytosol]
(R-HSA-8863132)
0.581
3
UniProt:P21579 SYT1
7
SYT1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869113)
SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]
(R-HSA-210536)
SYT1 [synaptic vesicle membrane]
(R-HSA-194789)
SYT1 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-372514)
SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917741)
SYT1 [plasma membrane]
(R-HSA-168786)
SYT1 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-372508)
0.581
3
UniProt:P05783 KRT18
1
KRT18 [cytosol]
(R-HSA-201582)
0.57
3
UniProt:P63261 ACTG1
3
ACTG1 [cytosol]
(R-HSA-201858)
ACTG1 [lysosomal membrane]
(R-HSA-196169)
ACTG1 [plasma membrane]
(R-HSA-196044)
0.564
2
UniProt:Q15653 NFKBIB
3
p-S19,S23-Ub-NFKBIB [cytosol]
(R-HSA-1168571)
p-S19,S23-NFKBIB [cytosol]
(R-HSA-177670)
NFKBIB [cytosol]
(R-HSA-168132)
0.564
2
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.564
3
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.564
2
UniProt:Q99633 PRPF18
1
PRPF18 [nucleoplasm]
(R-HSA-5688093)
0.556
3
UniProt:Q9H0I2 ENKD1
0.556
3
UniProt:Q04712 RRN11
0.556
3
UniProt:P0DTD1-PRO_0000449631 REP
0.556
3
UniProt:Q96PV6 LENG8
0.556
3
UniProt:Q7Z4H3 HDDC2
0.556
3
UniProt:Q96SQ5 ZNF587
1
ZNF587 [nucleoplasm]
(R-HSA-2127565)
0.556
3
UniProt:Q9UJX0 OSGI1
0.556
3
UniProt:Q92917 GPKOW
1
GPKOW [nucleoplasm]
(R-HSA-8850839)
0.556
3
UniProt:Q9Y2X8 UBE2D4
1
UBE2D4 [cytosol]
(R-HSA-947623)
0.556
3
UniProt:Q9Y2P0 ZN835
0.556
3
UniProt:Q2TBE0 CWF19L2
1
CWF19L2 [nucleoplasm]
(R-HSA-9770846)
0.556
3
UniProt:P28074 PSMB5
4
PSMB5(1-59) [cytosol]
(R-HSA-9908134)
pro-PSMB5 [cytosol]
(R-HSA-9908135)
PSMB5 [nucleoplasm]
(R-HSA-174344)
PSMB5 [cytosol]
(R-HSA-68753)
0.556
3
UniProt:O95391 SLU7
1
hSLU7 [nucleoplasm]
(R-HSA-72073)
0.556
3
UniProt:P04083 ANXA1
2
ANXA1 [cytosol]
(R-HSA-5263630)
ANXA1 [extracellular region]
(R-HSA-444539)
0.556
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P29083 GTF2E1
1
GTF2E1 [nucleoplasm]
(R-HSA-65561)
0.547
2
UniProt:Q9NQC7 CYLD
3
K48polyUb-K338, K530-CYLD [cytosol]
(R-HSA-9818664)
p-S418-CYLD [cytosol]
(R-HSA-5212667)
CYLD [cytosol]
(R-HSA-741420)
0.547
2
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.527
2
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.527
3
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.524
2
UniProt:Q13315 ATM
5
Ac-K3016-ATM [nucleoplasm]
(R-HSA-5682043)
ATM [nucleoplasm]
(R-HSA-69484)
p-S1981,Ac-K3016-ATM [nucleoplasm]
(R-HSA-5693527)
ATM [peroxisomal matrix]
(R-HSA-9665169)
ATM [cytosol]
(R-HSA-9665171)
0.524
4
UniProt:Q5D1E8 ZC3H12A
1
ZC3H12A [nucleoplasm]
(R-HSA-9774235)
0.524
2
UniProt:P05787 KRT8
1
KRT8 [cytosol]
(R-HSA-446043)
0.508
2
UniProt:Q9UNS2 COPS3
2
COPS3 [cytosol]
(R-HSA-416973)
COPS3 [nucleoplasm]
(R-HSA-5697017)
0.508
2
UniProt:Q4VCS5 AMOT
0.499
3
UniProt:Q9BVN2-2 RUSC1
0.499
4
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.499
3
UniProt:Q13535 ATR
1
ATR [nucleoplasm]
(R-HSA-912443)
0.499
2
UniProt:Q9NYJ8 TAB2
4
TAB2 [cytosol]
(R-HSA-168117)
TAB2 [endosome membrane]
(R-HSA-450279)
TAB2 [plasma membrane]
(R-HSA-168116)
TAB2 [nucleoplasm]
(R-HSA-1253323)
0.488
2
UniProt:P0DTD2 9b
3
p-S53-9b [cytosol]
(R-COV-9758478)
9b [cytosol]
(R-COV-9694649)
9b [mitochondrial outer membrane]
(R-COV-9709803)
0.463
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.463
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text