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IKBKB [cytosol]
Stable Identifier
R-HSA-168114
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
IKKB, IKK2, IKK-beta, Inhibitor of nuclear factor kappa B kinase beta subunit
Icon
Locations in the PathwayBrowser for interactor UniProt:P24772 PG200
Expand all
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) (Homo sapiens)
Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
LRRC14 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
LRRC14 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
LRRC14 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
LRRC14 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
LRRC14 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
LRRC14 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
LRRC14 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
LRRC14 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
LRRC14 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
LRRC14 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
IKBKB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14920 IKBKB
Gene Names
IKBKB, IKKB
Chain
chain:1-756
Reference Genes
BioGPS Gene:3551 IKBKB
COSMIC (genes):IKBKB IKBKB
CTD Gene:3551 IKBKB
dbSNP Gene:3551 IKBKB
ENSEMBL:ENSG00000104365 IKBKB
HGNC:5960 IKBKB
KEGG:hsa:3551 IKBKB
Monarch:3551 IKBKB
NCBI Gene:3551 IKBKB
OMIM:603258 IKBKB
UCSC:O14920 IKBKB
Reference Transcript
RefSeq:NM_001242778.1 IKBKB
RefSeq:NM_001556.2 IKBKB
RefSeq:NM_001190720.2 IKBKB
Other Identifiers
11730928_a_at
11730929_s_at
11730930_a_at
11745356_a_at
11746063_a_at
11746648_a_at
11750345_a_at
11752235_x_at
11753155_x_at
11755411_a_at
11755412_x_at
17068462
209341_PM_s_at
209341_s_at
209342_PM_s_at
209342_s_at
211027_3p_s_at
211027_PM_s_at
211027_s_at
3096093
3096094
3096095
3096096
3096097
3096103
3096105
3096108
3096109
3096118
3096119
3096123
3096125
3096126
3096127
3096128
3096129
3096130
3096131
3096132
3096133
3096134
3096135
3096136
3096137
3096138
3096139
3096140
3096141
3096142
3096143
3096144
3096145
3096146
3096147
3096148
3096149
3096150
3096151
3096153
3096154
3096155
3096156
3096157
3096158
3096159
3096160
3096161
3096162
3096163
3096164
3551
35960_at
44812_at
54675_at
54679_g_at
65461_r_at
8146171
A_23_P216188
A_24_P132518
A_24_P155058
A_33_P3241756
GE62527
GE781692
GO:0002223
GO:0002376
GO:0002479
GO:0002755
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006355
GO:0006468
GO:0006954
GO:0007010
GO:0007249
GO:0008384
GO:0008385
GO:0009615
GO:0009898
GO:0010604
GO:0010803
GO:0016020
GO:0016740
GO:0018105
GO:0019901
GO:0030866
GO:0031399
GO:0033209
GO:0034121
GO:0034138
GO:0035509
GO:0035631
GO:0035666
GO:0038095
GO:0042325
GO:0042802
GO:0042803
GO:0043123
GO:0043226
GO:0045087
GO:0045121
GO:0045893
GO:0045944
GO:0046982
GO:0050852
GO:0051092
GO:0051403
GO:0051604
GO:0070498
GO:0071356
GO:0072659
GO:0097110
GO:0098542
GO:0106310
GO:0140096
GO:1903140
GO:1903347
GO:1990459
HMNXSV003011838
HMNXSV003029800
HMNXSV003035882
HMNXSV003057127
Hs.226573.0.S3_3p_a_at
Hs.226573.0.S3_3p_x_at
ILMN_1727142
ILMN_2172588
PH_hs_0024951
TC08000325.hg
TC08001896.hg
g13623262_3p_at
g13623262_3p_x_at
g4185274_3p_a_at
p33839
Participates
as a component of
FKBP5:CHUK:IKBKB:IKBKG [cytosol] (Homo sapiens)
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Homo sapiens)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Homo sapiens)
IKBKB dimer [cytosol] (Homo sapiens)
CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
CHUK:IKBKB:IKBKG [cytosol] (Homo sapiens)
as an input of
Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) (Homo sapiens)
LRRC14 binds IKBKB and CHUK (Homo sapiens)
IKBIP binds IKBKB and CHUK (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)
as an output of
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
Other forms of this molecule
p-S177,S181-IKBKB [cytosol]
IKBKB Q432Pfs*62 [cytosol]
Inferred To
IKBKB [cytosol]
(Bos taurus)
IKBKB [cytosol]
(Canis familiaris)
IKBKB [cytosol]
(Drosophila melanogaster)
IKBKB [cytosol]
(Gallus gallus)
IKBKB [cytosol]
(Mus musculus)
IKBKB [cytosol]
(Rattus norvegicus)
IKBKB [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001177649.1
,
NP_001229707.1
,
NP_001547.1
ZINC - World Drugs
IKKB_HUMAN
Guide to Pharmacology - Targets
2039
OpenTargets
ENSG00000104365
ENSEMBL
ENSP00000430684
,
ENST00000520810
ZINC - FDA approved
IKKB_HUMAN
ZINC - Substances
IKKB_HUMAN
ZINC - Biogenic
IKKB_HUMAN
ZINC target
O14920
PRO
O14920
GlyGen
O14920
PDB
4KIK
,
3BRT
,
8OMV
,
4E3C
,
3BRV
ZINC - Investigational
IKKB_HUMAN
IntEnz
2.7.11.10
HPA
ENSG00000104365-IKBKB
Pharos - Targets
O14920
Orphanet
IKBKB
ZINC - Predictions - Purchasable
IKKB_HUMAN
HMDB Protein
HMDBP01302
Interactors (31)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6K9 IKBKG
12
IKBKG [cytosol]
(R-HSA-168108)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
IKBKG [nucleoplasm]
(R-HSA-4755413)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG D406V [cytosol]
(R-HSA-5262943)
0.982
40
UniProt:P25963 NFKBIA
9
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
0.969
27
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.956
21
UniProt:Q99558 MAP3K14
5
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
0.904
7
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.869
9
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.848
8
UniProt:P19838 NFKB1
8
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
0.773
4
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.755
4
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
p-MAP3K7 [cytosol]
(R-HSA-168163)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.657
6
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.643
4
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.641
3
UniProt:Q9UGK3 STAP2
2
STAP2 [cytosol]
(R-HSA-8848028)
p-Y250-STAP2 [plasma membrane]
(R-HSA-8848079)
0.623
7
UniProt:P24772 PG200
0.623
3
UniProt:Q92574 TSC1
2
TSC1 [cytosol]
(R-HSA-5672338)
TSC1 [plasma membrane]
(R-HSA-165169)
0.611
3
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.61
6
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.609
2
UniProt:P23396 RPS3
2
RPS3 [cytosol]
(R-HSA-72369)
RPS3 [nucleoplasm]
(R-HSA-6798714)
0.602
4
UniProt:Q5D1E7
1
ZC3H12A [nucleoplasm]
(R-MMU-9774235)
0.591
4
UniProt:P03409 TAX
0.589
3
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.581
7
UniProt:Q15653 NFKBIB
3
p-S19,S23-Ub-NFKBIB [cytosol]
(R-HSA-1168571)
p-S19,S23-NFKBIB [cytosol]
(R-HSA-177670)
NFKBIB [cytosol]
(R-HSA-168132)
0.564
2
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.564
2
UniProt:O14965 AURKA
6
p-T288-AURKA [cytosol]
(R-HSA-2574832)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
AURKA [nucleoplasm]
(R-HSA-4655443)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
0.544
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.536
3
UniProt:Q00610 CLTC
10
CLTC [trans-Golgi network membrane]
(R-HSA-5333703)
CLTC [cytosol]
(R-HSA-8856820)
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol]
(R-HSA-9710852)
CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710854)
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9710835)
CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710853)
CLTC [endolysosome membrane]
(R-HSA-8870827)
CLTC [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138450)
CLTC [lysosomal membrane]
(R-HSA-2980660)
CLTC [plasma membrane]
(R-HSA-2980668)
0.536
2
UniProt:Q86WI3 NLRC5
2
K63polyUb-NLRC5 [cytosol]
(R-HSA-9750938)
NLRC5 [cytosol]
(R-HSA-937324)
0.524
2
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
0.512
4
UniProt:Q9UKE5 TNIK
1
TNIK [cytosol]
(R-HSA-3214889)
0.499
2
UniProt:P03230 LMP1
0.499
2
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.483
2
UniProt:Q92793 CREBBP
4
CREBBP [nucleoplasm]
(R-HSA-193545)
CREBBP [cytosol]
(R-HSA-9756493)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
0.483
2
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