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TAB2 [plasma membrane]
Stable Identifier
R-HSA-168116
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Mitogen-activated protein kinase kinase kinase 7 interacting protein 2
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Activation of IKK complex (Homo sapiens)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Homo sapiens)
phosphorylated TAK1 bound to TAB2 [cytosol] (Homo sapiens)
TAB2 [plasma membrane] (Homo sapiens)
Activation of TAK1-TAB2 complex (Homo sapiens)
TAB2/TAK1 complex [cytosol] (Homo sapiens)
TAB2 [plasma membrane] (Homo sapiens)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Homo sapiens)
phosphorylated TAK1 bound to TAB2 [cytosol] (Homo sapiens)
TAB2 [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
K63 polyubiquitinated RIP2 associates with the TAK1 complex (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Homo sapiens)
TAK1 complex [plasma membrane] (Homo sapiens)
TAB2,TAB3 [plasma membrane] (Homo sapiens)
TAB2 [plasma membrane] (Homo sapiens)
TAK1 complex [plasma membrane] (Homo sapiens)
TAB2,TAB3 [plasma membrane] (Homo sapiens)
TAB2 [plasma membrane] (Homo sapiens)
TAK1 is activated (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Homo sapiens)
TAK1 complex [plasma membrane] (Homo sapiens)
TAB2,TAB3 [plasma membrane] (Homo sapiens)
TAB2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYJ8 TAB2
Gene Names
TAB2, KIAA0733, MAP3K7IP2
Chain
chain:1-693
Reference Genes
BioGPS Gene:23118 TAB2
COSMIC (genes):TAB2 TAB2
CTD Gene:23118 TAB2
dbSNP Gene:23118 TAB2
ENSEMBL:ENSG00000055208 TAB2
ENSEMBL_homo_sapiens_GENE:ENSG00000055208.20 TAB2
HGNC:17075 TAB2
KEGG Gene (Homo sapiens):23118 TAB2
Monarch:23118 TAB2
NCBI Gene:23118 TAB2
OMIM:605101 TAB2
UCSC:Q9NYJ8 TAB2
Reference Transcript
RefSeq:NM_001292034.2 TAB2
RefSeq:NM_001292035.2 TAB2
RefSeq:NM_015093.5 TAB2
RefSeq:XM_011535633.2 TAB2
RefSeq:XM_017010591.1 TAB2
RefSeq:XM_017010592.1 TAB2
Other Identifiers
11743012_at
11750741_a_at
11754101_x_at
11757315_s_at
17013567
210284_PM_s_at
210284_s_at
212184_PM_s_at
212184_s_at
23118
2930603
2930606
2930616
2930623
2930624
2930627
2930628
2930629
2930633
2930635
2930636
2930637
2930642
2930643
2930644
2930645
2930646
2930647
2930648
2930649
2930650
2930651
2930652
2930706
38980_at
8122672
A_14_P121269
A_14_P135290
A_23_P19702
A_33_P3404331
GE56455
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0006914
GO:0006954
GO:0007507
GO:0008270
GO:0010008
GO:0010507
GO:0016020
GO:0023052
GO:0031410
GO:0032496
GO:0036211
GO:0038061
GO:0042742
GO:0043123
GO:0043130
GO:0043226
GO:0045860
GO:0046872
GO:0048856
GO:0060090
GO:0070530
GO:0098542
HMNXSV003018647
Hs.109727.1.S1_3p_a_at
ILMN_1672331
ILMN_1808322
PH_hs_0006053
PH_hs_0040402
g7677465_3p_a_at
Participates
as a component of
phosphorylated TAK1 bound to TAB2 [cytosol] (Homo sapiens)
TAB2/TAK1 complex [cytosol] (Homo sapiens)
as a member of
TAB2,TAB3 [plasma membrane] (Homo sapiens)
Other forms of this molecule
TAB2 [cytosol]
TAB2 [endosome membrane]
TAB2 [nucleoplasm]
Inferred To
TAB2 [plasma membrane]
(Bos taurus)
TAB2 [plasma membrane]
(Canis familiaris)
TAB2 [plasma membrane]
(Gallus gallus)
TAB2 [plasma membrane]
(Sus scrofa)
tab2 [plasma membrane]
(Xenopus tropicalis)
Tab2 [plasma membrane]
(Mus musculus)
Tab2 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001278963.1
,
XP_016866081.1
,
XP_011533935.1
,
NP_001278964.1
,
XP_016866080.1
,
NP_055908.1
OpenTargets
ENSG00000055208
GeneCards
Q9NYJ8
HPA
ENSG00000055208-TAB2
Ensembl
ENST00000367456
,
ENSP00000356426
,
ENSP00000432709
,
ENSG00000055208
,
ENST00000470466
,
ENSP00000490618
,
ENST00000637181
PRO
Q9NYJ8
Pharos - Targets
Q9NYJ8
Orphanet
24961
PDB
2DAE
,
2WX1
,
2WWZ
,
2WX0
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
p-MAP3K7 [cytosol]
(R-HSA-168163)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.91
8
UniProt:Q15750 TAB1
6
TAB1(445-504) [cytosol]
(R-HSA-9729691)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1 [cytosol]
(R-HSA-167923)
0.902
9
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.678
3
UniProt:Q14457 BECN1
4
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
BECN1 [cytosol]
(R-HSA-1632841)
0.655
11
UniProt:Q62073 Map3k7
10
Phospho TAK1 [cytosol]
(R-MMU-205840)
PolyUb-MAP3K7 [cytosol]
(R-MMU-6782968)
phospho-K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-MMU-5607649)
K63polyUb-34,158-TAK1 [cytosol]
(R-MMU-5607643)
phospho-p-MAP3K7 [cytosol]
(R-MMU-168163)
phospho-p-T187-MAP3K7 [cytosol]
(R-MMU-206014)
MAP3K7 [endosome membrane]
(R-MMU-450315)
phospho-p-T184,T187-MAP3K7 [endosome membrane]
(R-MMU-450332)
MAP3K7 [cytosol]
(R-MMU-168156)
phospho-p-T184,T187-MAP3K7 [cytosol]
(R-MMU-202527)
0.59
2
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.564
2
UniProt:P52747 ZNF143
1
ZNF143 [nucleoplasm]
(R-HSA-83837)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.536
2
UniProt:Q9Y2G2 CARD8
1
CARD8 [cytosol]
(R-HSA-6805447)
0.527
2
UniProt:Q8N4J0 CARNMT1
1
CARNMT1 [cytosol]
(R-HSA-8876689)
0.527
3
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.488
2
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