Little is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may also heterodimerize with TLRs 1 and 2. It is expressed in a restricted fashion as a highly N-glycosylated protein detectable in B cells and dendritic cells.
Nyman, T, Stenmark, P, Flodin, S, Johansson, I, Hammarström, M, Nordlund, P
Hasan, U, Chaffois, C, Gaillard, C, Saulnier, V, Merck, E, Tancredi, S, Guiet, C, Briere, F, Vlach, J, Lebecque, S, Trinchieri, G, Bates, EE
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