Little is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may also heterodimerize with TLRs 1 and 2. It is expressed in a restricted fashion as a highly N-glycosylated protein detectable in B cells and dendritic cells.
Merck, E, Chaffois, C, Trinchieri, G, Vlach, J, Saulnier, V, Hasan, U, Lebecque, S, Briere, F, Bates, EE, Tancredi, S, Guiet, C, Gaillard, C
Hammarström, M, Johansson, I, Nordlund, P, Stenmark, P, Flodin, S, Nyman, T
© 2023 Reactome
